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A. Kahru, Barbara Borchardt (1994)
Toxicity of 39 MEIC Chemicals to Bioluminescent Photobacteria (The Biotox™ Test): Correlation with Other Test SystemsAlternatives to Laboratory Animals, 22
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MEIC Evaluation of Acute Systemic Toxicity: Part V. Rodent and Human Toxicity Data for the 50 Reference Chemicals.Alternatives to laboratory animals : ATLA, 26 Suppl 2
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The toxicity of herbicides estimated with a bacterial test for toxic
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A simple, inexpensive and rapid method of determining toxicity by using a bacterium as the indicator organism was developed and compared with 23 other tests. The average correlation coefficient when comparing these 23 tests with the present test was 0.800, ranging from 0.580 to 0.950. Eleven of the tests were compared in detail by using 35 of the chemicals on the Multicentre Evaluation of In Vitro Cytotoxicity list of test chemicals. Comparing results from the present test with test results for these 35 chemicals with Microtox™, Biotox™, Daphnia magna, rat hepatocytes and ascites tumour cell resulted in correlation coefficients ranging from 0.871 to 0.933. Comparisons of the test data with rodent LD50 values, human lethal dose estimates from autopsies and human lethal doses obtained from the literature provided correlation coefficients ranging from 0.580 to 0.770, indicating that the test compares less favourably with these methods. This test provides data comparable to data from other ecotoxicological tests.
Alternatives to Laboratory Animals – SAGE
Published: Sep 1, 2002
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