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C. Heidelberger, A. Freeman, R. Pienta, A. Sivak, J. Bertram, B. Casto, V. Dunkel, M. Francis, T. Kakunaga, J. Little, L. Schechtman (1983)
Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program.Mutation research, 114 3
V. Chankong, Y. Haimes, H. Rosenkranz, J. Pet-Edwards (1985)
The carcinogenicity prediction and battery selection (CPBS) method: a Bayesian approach.Mutation research, 153 3
J. Pet-Edwards, Y. Haimes, V. Chankong, H. Rosenkranz, F. Ennever (1989)
The Carcinogenicity Prediction and Battery Selection Approach
M. Aardema, R. Isfort, E. Thompson, R. Leboeuf (1996)
The low pH Syrian hamster embryo (SHE) cell transformation assay: a revitalized role in carcinogen prediction.Mutation research, 356 1
J. Bradlaw, K. Gupta, Sidney Green, Richard Hill, N. Wilcox (1997)
Practical application of non-whole animal alternatives: summary of IRAG workshop on eye irritation testing. Interagency Regulatory Alternatives Group.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 35 1
J. Swenberg, B. Short, S. Borghoff, J. Strasser, M. Charbonneau (1989)
The comparative pathobiology of α2u-globulin nephropathyToxicology and Applied Pharmacology, 97
J. Pet-Edwards, Y. Haimes, V. Chankong, H. Rosenkranz, F. Ennever (1989)
Risk Assessment and Decision Making Using Test Results
(2000)
Evaluation of cytotoxicity using structure - activity relationship models
H. Spielmann, M. Liebsch, Sabine Kalweit, F. Moldenhauer, T. Wirnsberger, Hermann-Georg Holzhütter, B. Schneider, S. Glaser, I. Gerner, W. Pape, R. Kreiling, K. Krauser, H. Miltenburger, W. Steiling, Nils Luepke, N. Müller, H. Kreuzer, P. Mürmann, Jochen Spengler, E. Bertram-Neis, B. Siegemund, F. Wiebel (1996)
Results of a Validation Study in Germany on Two in Vitro Alternatives to the Draize Eye Irritation Test, the HET-CAM Test and the 3T3 NRU Cytotoxicity TestAlternatives to Laboratory Animals, 24
H. Rosenkranz, E. Matthews, G. Klopman (1992)
Relationships between Cellular Toxicity, the Maximum Tolerated Dose, Lipophilicity and ElectrophilicityAlternatives to Laboratory Animals, 20
B. Ekwall (1980)
Toxicity to HeLa cell of 205 drugs as determined by the metabolic inhibition test supplemented by microscopy.Toxicology, 17 3
Herbert Rosenkranz, Albert Cunningham, Y. Zhang, H. Claycamp, O. Macina, N. Sussman, Stephen Grant, Gilles Klopman (1999)
Development, characterization and application of predictive-toxicology models.SAR and QSAR in environmental research, 10 2-3
E. Matthews, J. Spalding, R. Tennant (1993)
Transformation of BALB/c-3T3 cells: V. Transformation responses of 168 chemicals compared with mutagenicity in Salmonella and carcinogenicity in rodent bioassays.Environmental Health Perspectives, 101
N. Pollack, A. Cunningham, G. Klopman, H. Rosenkranz (1999)
Chemical diversity approach for evaluating mechanistic relatedness among toxicological phenomena.SAR and QSAR in environmental research, 10 6
L. Lave, F. Ennever, H. Rosenkranz, G. Omenn (1988)
Information value of the rodent bioassayNature, 336
H. Rosenkranz, Y. Zhang, G. Klopman (1998)
The Development and Characterisation of a Structure-activity Relationship Model of the Draize Eye Irritation Test.Alternatives to laboratory animals : ATLA, 26 6
L. Bruner, H. Spira, M. Balls, R. Hill (1997)
Perspectives on alternatives to the eye irritation test: industry, public interest, government.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 35 1
(2000)
Evaluation of cytotoxicity using structure-activity relationship models. MSc Dissertation. Graduate School of Public Health, University of Pittsburgh
R. Leboeuf, G. Kerckaert, M. Aardema, D. Gibson, R. Brauninger, R. Isfort (1996)
The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals.Mutation research, 356 1
J. Harbell, S. Koontz, R. Lewis, D. Lovell, D. Acosta (1997)
IRAG working group 4: Cell cytotoxicity assaysFood and Chemical Toxicology, 35
M. Balls, P. Botham, L. Bruner, H. Spielmann (1995)
The EC/HO international validation study on alternatives to the draize eye irritation test.Toxicology in vitro : an international journal published in association with BIBRA, 9 6
The newly developed “chemical diversity approach” was used to determine whether or not it is likely that a panel of in vitro cell toxicity assays capable of predicting in vivo eye irritation could be assembled. The analyses, based upon available and validated structure–activity relationship models of toxicity in cultured human HeLa cells and murine Balb/c 3T3 cells, indicate that a battery of cytotoxicity tests could provide a viable alternative to the animal-based procedure.
Alternatives to Laboratory Animals – SAGE
Published: Jul 1, 2000
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