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A Battery of Cell Toxicity Assays as Predictors of Eye Irritation: A Feasibility Study

A Battery of Cell Toxicity Assays as Predictors of Eye Irritation: A Feasibility Study The newly developed “chemical diversity approach” was used to determine whether or not it is likely that a panel of in vitro cell toxicity assays capable of predicting in vivo eye irritation could be assembled. The analyses, based upon available and validated structure–activity relationship models of toxicity in cultured human HeLa cells and murine Balb/c 3T3 cells, indicate that a battery of cytotoxicity tests could provide a viable alternative to the animal-based procedure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alternatives to Laboratory Animals SAGE

A Battery of Cell Toxicity Assays as Predictors of Eye Irritation: A Feasibility Study

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References (21)

Publisher
SAGE
Copyright
© 2000 Fund for the Replacement of Animals in Medical Experiments
ISSN
0261-1929
eISSN
2632-3559
DOI
10.1177/026119290002800405
Publisher site
See Article on Publisher Site

Abstract

The newly developed “chemical diversity approach” was used to determine whether or not it is likely that a panel of in vitro cell toxicity assays capable of predicting in vivo eye irritation could be assembled. The analyses, based upon available and validated structure–activity relationship models of toxicity in cultured human HeLa cells and murine Balb/c 3T3 cells, indicate that a battery of cytotoxicity tests could provide a viable alternative to the animal-based procedure.

Journal

Alternatives to Laboratory AnimalsSAGE

Published: Jul 1, 2000

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