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Introduction

Introduction Cite this: Ian Cunningham DOI: 10.1039/c3oc90016a This year of 2013 sees the publication of volume 109 of . As usual, it offers a timely and pertinent selection of the latest advances in organic chemistry taken from the primary literature during the previous year. Each chapter presents a view from experts in the field. Gideon Grogan has once again provided a succinct, but wide-ranging, review of the literature for 2012 in the field of biotransformations. The potential for organic synthesis is amply illustrated by a selection that includes hydrolases, reductases, transaminases, oxidases­oxygenases, and others; even the cytochrome P450 family, once regarded as feral and difficult to control, has been tamed and harnessed for specific tasks, for example for the kinetic resolution of racemic mixtures and for regioselective hydroxylation. Carbon­carbon bond formations are at the heart of organic synthesis, and the report covers in some detail the use of enzymes to this end. While the prevalence of enzymes that catalyse aldol-type reactions might be expected, more surprisingly, even the Pictet­Spengler reaction (formation of a tetrahydroisoquinoline) has its enzymic understudy. The section on artificial metalloenzymes, (proteins or DNA scaffolds where a non-native metal is incorporated) suggests great potential for this particular http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Annual Reports Section "B" (Organic Chemistry) Royal Society of Chemistry

Introduction

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Publisher
Royal Society of Chemistry
Copyright
This journal is © The Royal Society of Chemistry
ISSN
0069-3030
eISSN
1460-4779
DOI
10.1039/c3oc90016a
Publisher site
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Abstract

Cite this: Ian Cunningham DOI: 10.1039/c3oc90016a This year of 2013 sees the publication of volume 109 of . As usual, it offers a timely and pertinent selection of the latest advances in organic chemistry taken from the primary literature during the previous year. Each chapter presents a view from experts in the field. Gideon Grogan has once again provided a succinct, but wide-ranging, review of the literature for 2012 in the field of biotransformations. The potential for organic synthesis is amply illustrated by a selection that includes hydrolases, reductases, transaminases, oxidases­oxygenases, and others; even the cytochrome P450 family, once regarded as feral and difficult to control, has been tamed and harnessed for specific tasks, for example for the kinetic resolution of racemic mixtures and for regioselective hydroxylation. Carbon­carbon bond formations are at the heart of organic synthesis, and the report covers in some detail the use of enzymes to this end. While the prevalence of enzymes that catalyse aldol-type reactions might be expected, more surprisingly, even the Pictet­Spengler reaction (formation of a tetrahydroisoquinoline) has its enzymic understudy. The section on artificial metalloenzymes, (proteins or DNA scaffolds where a non-native metal is incorporated) suggests great potential for this particular

Journal

Annual Reports Section "B" (Organic Chemistry) – Royal Society of Chemistry

Published: Oct 11, 2013

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