Abstract

There has long been a pressing clinical need to identify prognostic and predictive factors for patients with breast cancer. Although numerous candidate biological and molecular markers have been identified during the last two decades, traditional factors such as lymph node status, tumor size, histologic type, histologic grade, and hormone receptor status remain the most useful indicators of prognosis and therapeutic response. A major obstacle to the translation of research advances into clinically useful prognostic and predictive markers has been the considerable methodologic variability used in the evaluation of the newer markers. It is now generally accepted that, to be useful in patient management, a putative prognostic or predictive marker must have clinical importance, independence, significance, and standardization with regard to methods, interpretation, and reporting. It is hoped that recognition and adoption of these criteria will serve to clarify the value of newer biologic and molecular markers. © Oxford University Press « Previous | Next Article » Table of Contents This Article J Natl Cancer Inst Monogr (2001) 2001 (30): 22-26. This article appears in: The National Institutes of Health Consensus Development Conference: Adjuvant Therapy for Breast Cancer » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications I. FACTORS USED TO SELECT ADJUVANT THERAPY Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Schnitt, S. J. 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