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The Translation of Cognitive Paradigms for Patient Research

The Translation of Cognitive Paradigms for Patient Research Many cognitive tasks have been developed by basic scientists to isolate and measure specific cognitive processes in healthy young adults, and these tasks have the potential to provide important information about cognitive dysfunction in psychiatric disorders, both in psychopathology research and in clinical trials. However, several practical and conceptual challenges arise in translating these tasks for patient research. Here we outline a paradigm development strategywhich involves iteratively testing modifications of the tasks in college students, in older healthy adults, and in patientsthat we have used to successfully translate a large number of cognitive tasks for use in schizophrenia patients. This strategy makes it possible to make the tasks patient friendly while maintaining their cognitive precision. We also outline several measurement issues that arise in these tasks, including differences in baseline performance levels and speed-accuracy trade-offs, and we provide suggestions for addressing these issues. Finally, we present examples of 2 experiments, one of which exemplifies our recommendations regarding measurement issues and was a success and one of which was a painful but informative failure. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Schizophrenia Bulletin Oxford University Press

The Translation of Cognitive Paradigms for Patient Research

Schizophrenia Bulletin , Volume 34 (4) – May 16, 2008

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References (33)

Publisher
Oxford University Press
Copyright
The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
ISSN
0586-7614
eISSN
1745-1701
DOI
10.1093/schbul/sbn036
pmid
18487226
Publisher site
See Article on Publisher Site

Abstract

Many cognitive tasks have been developed by basic scientists to isolate and measure specific cognitive processes in healthy young adults, and these tasks have the potential to provide important information about cognitive dysfunction in psychiatric disorders, both in psychopathology research and in clinical trials. However, several practical and conceptual challenges arise in translating these tasks for patient research. Here we outline a paradigm development strategywhich involves iteratively testing modifications of the tasks in college students, in older healthy adults, and in patientsthat we have used to successfully translate a large number of cognitive tasks for use in schizophrenia patients. This strategy makes it possible to make the tasks patient friendly while maintaining their cognitive precision. We also outline several measurement issues that arise in these tasks, including differences in baseline performance levels and speed-accuracy trade-offs, and we provide suggestions for addressing these issues. Finally, we present examples of 2 experiments, one of which exemplifies our recommendations regarding measurement issues and was a success and one of which was a painful but informative failure.

Journal

Schizophrenia BulletinOxford University Press

Published: May 16, 2008

Keywords: cognitive assessment schizophrenia task development speed-accuracy tradeoffs

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