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C. Boyd, M. Fortin (2010)
Future of Multimorbidity Research: How Should Understanding of Multimorbidity Inform Health System Design?Public Health Reviews, 32
Susan Smith, H. Soubhi, M. Fortin, C. Hudon, T. O'dowd (2012)
Managing patients with multimorbidity: systematic review of interventions in primary care and community settingsThe BMJ, 345
R. Baldwin (2003)
National Service Framework for Older PeoplePsychiatric Bulletin, 27
M. Calvert, H. Duffy, N. Freemantle, R. Davis, G. Lip, P. Gill (2012)
Population health status of South Asian and African-Caribbean communities in the United KingdomBMC Health Services Research, 12
H. Bozdogan (1987)
Model selection and Akaike's Information Criterion (AIC): The general theory and its analytical extensionsPsychometrika, 52
M. Calvert, N. Freemantle, J. Cleland (2005)
The impact of chronic heart failure on health‐related quality of life data acquired in the baseline phase of the CARE‐HF studyEuropean Journal of Heart Failure, 7
P. Sullivan, V. Ghushchyan, E. Bayliss (2012)
The Impact of Co-Morbidity Burden on Preference-Based Health-Related Quality of Life in the United StatesPharmacoEconomics, 30
M. Calvert, A. Shankar, R. McManus, H. Lester, N. Freemantle (2009)
Effect of the quality and outcomes framework on diabetes care in the United Kingdom: retrospective cohort studyThe BMJ, 338
J. Murray, S. Saxena, C. Millett, V. Curcin, S. Lusignan, A. Majeed (2010)
Reductions in risk factors for secondary prevention of coronary heart disease by ethnic group in south-west London: 10-year longitudinal study (1998-2007).Family practice, 27 4
G. Persad, A. Wertheimer, E. Emanuel (2009)
Principles for allocation of scarce medical interventionsThe Lancet, 373
P. Dolan (1997)
Modeling valuations for EuroQol health states.Medical care, 35 11
D. Revicki (1989)
Health-related quality of life in the evaluation of medical therapy for chronic illness.The Journal of family practice, 29 4
M. Fortin, G. Bravo, C. Hudon, A. Vanasse, Lise Lapointe (2005)
Prevalence of Multimorbidity Among Adults Seen in Family PracticeThe Annals of Family Medicine, 3
C. Brettschneider, H. Leicht, H. Bickel, A. Dahlhaus, A. Fuchs, J. Gensichen, W. Maier, S. Riedel-Heller, I. Schäfer, G. Schön, S. Weyerer, B. Wiese, H. Bussche, M. Scherer, H. König, A. Altiner, H. Bickel, W. Blank, C. Brettschneider, M. Bullinger, H. Bussche, A. Dahlhaus, Lena Ehreke, M. Freitag, A. Fuchs, J. Gensichen, F. Gerlach, H. Hansen, S. Heinrich, S. Höfels, O. Knesebeck, H. König, Norbert Krause, H. Leicht, M. Luppa, W. Maier, M. Mayer, C. Mellert, A. Nützel, T. Paschke, J. Petersen, J. Prokein, S. Riedel-Heller, H. Romberg, I. Schäfer, M. Scherer, G. Schön, S. Steinmann, Sven Schulz, K. Wegscheider, K. Weckbecker, J. Werle, S. Weyerer, B. Wiese, M. Zieger (2013)
Relative Impact of Multimorbid Chronic Conditions on Health-Related Quality of Life – Results from the MultiCare Cohort StudyPLoS ONE, 8
I. Bjelland, A. Dahl, T. Haug, D. Neckelmann (2002)
The validity of the Hospital Anxiety and Depression Scale. An updated literature review.Journal of psychosomatic research, 52 2
Susan Wilson, J. Parle, L. Roberts, A. Roalfe, F. Hobbs, P. Clark, M. Sheppard, M. Gammage, H. Pattison, J. Franklyn (2006)
Prevalence of subclinical thyroid dysfunction and its relation to socioeconomic deprivation in the elderly: a community-based cross-sectional survey.The Journal of clinical endocrinology and metabolism, 91 12
S. Walters, J. Brazier (2005)
Comparison of the minimally important difference for two health state utility measures: EQ-5D and SF-6DQuality of Life Research, 14
O. Ethgen, K. Kahler, S. Kong, J. Reginster, F. Wolfe (2002)
The effect of health related quality of life on reported use of health care resources in patients with osteoarthritis and rheumatoid arthritis: a longitudinal analysis.The Journal of rheumatology, 29 6
P. Kind, P. Dolan, C. Gudex, Alan Williams (1998)
Variations in population health status: results from a United Kingdom national questionnaire surveyBMJ, 316
Karen Barnett, S. Mercer, M. Norbury, G. Watt, S. Wyke, B. Guthrie (2012)
Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional studyThe Lancet, 380
V. Watson, M. Sutton, C. Dibben, M. Ryan (2008)
Deriving weights for the Index of Multiple Deprivation based on societal preferences: The application of a discrete choice experiment *
K. Fiscella, A. Fremont (2006)
Use of geocoding and surname analysis to estimate race and ethnicity.Health services research, 41 4 Pt 1
Isobel Heyworth, M. Hazell, M. Linehan, T. Frank (2009)
How do common chronic conditions affect health-related quality of life?The British journal of general practice : the journal of the Royal College of General Practitioners, 59 568
C. McCulloch, S. Searle (2001)
Generalized, Linear, and Mixed Models
Background.Given the high prevalence of chronic conditions and multimorbidity in the elderly, there is a need to determine which chronic conditions have the greatest impact on health-related quality of life (HRQL) and identify where additional intervention may be required.Objective.To explore the impact of a range of common chronic conditions on HRQL in a community-based population aged 65 years or more in the UK.Methods.Secondary analysis of data derived from a large (n = 5849) cross-sectional study. HRQL was assessed using the EuroQoL EQ-5D. Multivariable models were used to estimate the relative effect of 15 individual common chronic conditions and combinations of these conditions on HRQL.Results.Mean age of participants was 74.6 years, 49.2% were male. The mean EQ-5D index score was 0.78 (standard deviation 0.2), range −0.43 to 1.00. Overall, 53% (n = 3078) of the cohort reported problems with pain, 39% (n = 2273) with mobility and 9% (n = 529) with self-care. Multivariate modelling demonstrated that impaired HRQL was significantly associated with 13 of the 15 common chronic conditions studied. Clinically meaningful reductions in EQ-5D index scores were observed for osteoarthritis (−0.081, P = 0.0006), neurological disease (−0.172, P < 0.0001) and depression (−0.269, P < 0.001).Conclusions.This study quantifies the relative impact of 13 common chronic conditions on HRQL in a UK-based community-dwelling ageing population. Findings indicate that osteoarthritis, depression and neurological disease have a strong clinically important negative effect on HRQL. These findings may help clinical decision making and priority setting for management of individuals with multimorbidity.
Family Practice – Oxford University Press
Published: Oct 1, 2014
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