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Metabolic syndrome and associated urolithiasis in adults enrolled in a community-based health program

Metabolic syndrome and associated urolithiasis in adults enrolled in a community-based health... Background.Urolithiasis is a common and recurrent disease, whose prevalence rate has recently increased in parallel to obesity pandemic.Objectives.To estimate the prevalence of history of urolithiasis in a non-randomized sample of adults assisted by a community-based health program and to analyze its association with metabolic syndrome.Methods.Cross-sectional study set in Niteroi, Rio de Janeiro, Brazil, including adults (non-diabetic hypertensives, diabetics or controls). Participants were assessed through a standardized questionnaire and underwent clinical and laboratory evaluation, including blood and urine samples. The diagnosis of metabolic syndrome was based on harmonized criteria.Results.A total of 740 adults were enrolled (M: F = 0.85; 43±12 years; 30% white, and 70% non-white). Almost half of subjects (42.5%) had metabolic syndrome. The prevalence of urolithiasis in the sample was 10.1%. White skin colour, family history, and metabolic syndrome were independently associated with urolithiasis (P < 0.05). Subjects with the syndrome (excluding cases on diuretics) had more acidic urine (P = 0.014), increased natriuresis (P = 0.01) and higher uricosuria (P = 0.001) compared with non-affected ones. The prevalence of urolithiasis increased in proportion to the number of criteria for metabolic syndrome (P for trend <0.005).Conclusions.Metabolic syndrome is a modifiable factor associated with urolithiasis in a way that the frequency of positive history increases proportionally to the number of its diagnostic criteria. These findings reinforce the recent suggested link between urolithiasis and cardiovascular risk factors. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Family Practice Oxford University Press

Metabolic syndrome and associated urolithiasis in adults enrolled in a community-based health program

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References (28)

Publisher
Oxford University Press
Copyright
© The Author 2012. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Subject
Original Article
ISSN
0263-2136
eISSN
1460-2229
DOI
10.1093/fampra/cms075
pmid
23180816
Publisher site
See Article on Publisher Site

Abstract

Background.Urolithiasis is a common and recurrent disease, whose prevalence rate has recently increased in parallel to obesity pandemic.Objectives.To estimate the prevalence of history of urolithiasis in a non-randomized sample of adults assisted by a community-based health program and to analyze its association with metabolic syndrome.Methods.Cross-sectional study set in Niteroi, Rio de Janeiro, Brazil, including adults (non-diabetic hypertensives, diabetics or controls). Participants were assessed through a standardized questionnaire and underwent clinical and laboratory evaluation, including blood and urine samples. The diagnosis of metabolic syndrome was based on harmonized criteria.Results.A total of 740 adults were enrolled (M: F = 0.85; 43±12 years; 30% white, and 70% non-white). Almost half of subjects (42.5%) had metabolic syndrome. The prevalence of urolithiasis in the sample was 10.1%. White skin colour, family history, and metabolic syndrome were independently associated with urolithiasis (P < 0.05). Subjects with the syndrome (excluding cases on diuretics) had more acidic urine (P = 0.014), increased natriuresis (P = 0.01) and higher uricosuria (P = 0.001) compared with non-affected ones. The prevalence of urolithiasis increased in proportion to the number of criteria for metabolic syndrome (P for trend <0.005).Conclusions.Metabolic syndrome is a modifiable factor associated with urolithiasis in a way that the frequency of positive history increases proportionally to the number of its diagnostic criteria. These findings reinforce the recent suggested link between urolithiasis and cardiovascular risk factors.

Journal

Family Practice – Oxford University Press

Published: Jun 26, 2013

Keywords: Keywords. Diabetes mellitus hypertension metabolic syndrome X uric acid urolithiasis.

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