Executive Summary
Abstract
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By continuing to use our website, you are agreeing to our use of cookies. You can change your cookie settings at any time. Find out more Skip Navigation Oxford Journals Contact Us My Basket My Account JNCI Monographs About This Journal Contact This Journal Subscriptions View Current Issue (Volume 2015 Issue 51 May 2015) Archive Search Institution: :: Sign In as Personal Subscriber Oxford Journals Medicine & Health JNCI Monographs Volume 2001 Issue 29 Pp. 3-5. Executive Summary Douglas E. Peterson and Stephen T. Sonis Affiliations of authors: D. E. Peterson, School of Dental Medicine, Department of Oral Diagnosis, University of Connecticut Health Center, Farmington; S. T. Sonis, Brigham and Women's Hospital and Dana-Farber Cancer Institute, Divisions of Oral Medicine, Oral and Maxillofacial Surgery, and Dentistry, Boston, MA. Correspondence to: Douglas E. Peterson, D.M.D., Ph.D., School of Dental Medicine, Department of Oral Diagnosis, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030-1605 (e-mail: Peterson@NSO.UCHC.EDU ). B ackground and S ignificance This conference was designed to generate innovative ideas that will ultimately lead to enhanced understanding of mucosal injury and strategically improved therapies for cancer patients. There has been an impressive recent history relative to publications about and funding directed toward mucosal injury in cancer patients. In addition, professional organizations, including the International Society for Oral Oncology and the Multinational Association of Supportive Care in Cancer, have targeted mucositis as a major toxicity of cancer treatment for which new research and standards of care are needed. In this context, conference participants critically evaluated the current status of science relative to mucosal injury in cancer patients and delineated future research directions that could ultimately lead to new management strategies. The conference format consisted of a lecture series, multiple workgroup discussions, and a summary plenary session. The research directions that emerged are summarized below. Successful pursuit of these research themes could lead to clinically important advances in the amelioration of cancer therapy-associated mucositis as well as to enhanced quality of life (QOL) for patients. The research could also potentially permit use of new, more aggressive cytoreductive cancer therapy that results in more durable remissions and improved long-term patient survival rates. F uture R esearch D irections The following two principles were identified as the foundation for establishing new research directions: The etiology, progression, and resolution of cancer therapy-associated mucositis are multifactorial in nature. The best research model is ultimately the human model. Specific research themes follow. Models for the Study of Mucosal Biology, Injury, and Repair Mucositis is an important model for the study of mucosal biology, injury, and repair. The discovery of potent agents that might protect or promote healing of the mucosal lining could lead to therapeutic, curative approaches rather than to palliation in cancer patients. Most therapeutic molecules identified to date are cytokines that affect epithelial proliferation. Basic, translational, and applied research involving the most promising … (Full Text of this Article) « Previous | Next Article » Table of Contents This Article J Natl Cancer Inst Monogr (2001) 2001 (29): 3-5. 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