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Epidemiology of Acquisition and Clearance of Cervical Human Papillomavirus Infection in Women from a High-Risk Area for Cervical Cancer

Epidemiology of Acquisition and Clearance of Cervical Human Papillomavirus Infection in Women... Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in São Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months. The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6–15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5–11.9). Median retention times were 8.1 months (95% CI, 7.8–8.3) for oncogenic types and 4.8 months (95% CI, 3.9–5.6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13–14 months), nononcogenic-type infections lasted longer (10.2 months) among younger (<35 years old) than in older women (5.6 months). http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Infectious Diseases Oxford University Press

Epidemiology of Acquisition and Clearance of Cervical Human Papillomavirus Infection in Women from a High-Risk Area for Cervical Cancer

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References (27)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
Major Articles
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1086/315086
pmid
10515798
Publisher site
See Article on Publisher Site

Abstract

Acquisition and clearance of cervical human papillomavirus (HPV) infection were analyzed among 1425 low-income women attending a maternal and child health program in São Paulo, Brazil. Specimens collected every 4 months were tested by a polymerase chain reaction protocol (MY09/11). In all, 357 subjects were positive at least once. There were 1.3% new infections per month, with 38% cumulative positivity after 18 months. Of 177 positive subjects at enrollment, only 35% remained infected after 12 months. The monthly clearance rate was higher for nononcogenic types (12.2%; 95% confidence interval [CI], 9.6–15.4) than for oncogenic HPV infections (9.5%; 95% CI, 7.5–11.9). Median retention times were 8.1 months (95% CI, 7.8–8.3) for oncogenic types and 4.8 months (95% CI, 3.9–5.6) for nononcogenic HPV infections. The mean infection durations were 8.2 and 13.5 months for nononcogenic and oncogenic types, respectively. Although a woman's age did not affect mean duration for oncogenic types (13–14 months), nononcogenic-type infections lasted longer (10.2 months) among younger (<35 years old) than in older women (5.6 months).

Journal

Journal of Infectious DiseasesOxford University Press

Published: Nov 1, 1999

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