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Dyspepsia in general practice: incidence, risk factors, comorbidity and mortality

Dyspepsia in general practice: incidence, risk factors, comorbidity and mortality Background. Many individuals consulting their GP with upper abdominal symptoms are initially classified as having dyspepsia. Few studies have described the incidence of dyspepsia or the comorbidities, risk factors or prognosis associated with this diagnosis.Methods. We used the UK General Practice Research Database to find patients with a new diagnosis of dyspepsia in 1996 (n6913) and a control cohort (n11036). We determined the incidence of dyspepsia, potential risk factors and comorbidity, and the risk of new onset morbidity in the year following the index date.Results. The incidence of dyspepsia was 15.3 per 1000 person-years. An increased probability of a dyspepsia diagnosis was associated with chest pain [odds ratio (OR): 2.4], general pain (OR: 1.8), sleep disorders (OR: 1.5), angina (OR: 1.5), osteoarthritis/rheumatoid arthritis (OR: 1.4) and smoking (OR: 1.2). There was only a borderline association with obesity (OR: 1.1). Patients with dyspepsia had an increased likelihood of a diagnosis of irritable bowel syndrome (IBS) (OR: 264), gastroesophageal reflux disease (GERD) (OR: 62.8) or peptic ulcer disease (PUD) (OR: 27.2) during the following year.Conclusions. The commonest diagnosis to emerge after an initial consultation for dyspepsia was IBS, followed by GERD and PUD. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Family Practice Oxford University Press

Dyspepsia in general practice: incidence, risk factors, comorbidity and mortality

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References (62)

Publisher
Oxford University Press
Copyright
The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org.
ISSN
0263-2136
eISSN
1460-2229
DOI
10.1093/fampra/cmm050
pmid
17728288
Publisher site
See Article on Publisher Site

Abstract

Background. Many individuals consulting their GP with upper abdominal symptoms are initially classified as having dyspepsia. Few studies have described the incidence of dyspepsia or the comorbidities, risk factors or prognosis associated with this diagnosis.Methods. We used the UK General Practice Research Database to find patients with a new diagnosis of dyspepsia in 1996 (n6913) and a control cohort (n11036). We determined the incidence of dyspepsia, potential risk factors and comorbidity, and the risk of new onset morbidity in the year following the index date.Results. The incidence of dyspepsia was 15.3 per 1000 person-years. An increased probability of a dyspepsia diagnosis was associated with chest pain [odds ratio (OR): 2.4], general pain (OR: 1.8), sleep disorders (OR: 1.5), angina (OR: 1.5), osteoarthritis/rheumatoid arthritis (OR: 1.4) and smoking (OR: 1.2). There was only a borderline association with obesity (OR: 1.1). Patients with dyspepsia had an increased likelihood of a diagnosis of irritable bowel syndrome (IBS) (OR: 264), gastroesophageal reflux disease (GERD) (OR: 62.8) or peptic ulcer disease (PUD) (OR: 27.2) during the following year.Conclusions. The commonest diagnosis to emerge after an initial consultation for dyspepsia was IBS, followed by GERD and PUD.

Journal

Family Practice – Oxford University Press

Published: Aug 28, 2007

Keywords: Diagnosis dyspepsia gastroesophageal reflux disease incidence irritable bowel syndrome

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