Access the full text.
Sign up today, get DeepDyve free for 14 days.
(2012)
Verordnung u ¨ ber klinische Versuche mit Heilmitteln http
J. Wright, W. Cushman, B. Davis, J. Barzilay, Pedro Colon, D. Egan, T. Lucente, C. Nwachuku, S. Pressel, F. Leenen, J. Frolkis, R. Letterer, Sandra Walsh, J. Tobin, G. Deger (2001)
The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT): clinical center recruitment experience.Controlled clinical trials, 22 6
(1999)
study: successes and failures.Cardiovasc RevRep
(2009)
German Society of Hypertension]. Leitlinien zur Hypertonie 2009 [Guidelines to Hypertension
F. Turnbull, B. Neal, T. Ninomiya, C. Algert, H. Arima, F. Barzi, C. Bulpitt, J. Chalmers, R. Fagard, A. Gleason, S. Heritier, N. Li, V. Perkovic, M. Woodward, S. MacMahon (2008)
Effects of different regimens to lower blood pressure on major cardiovascular events in older and younger adults: meta-analysis of randomised trialsBMJ : British Medical Journal, 336
L. Hansson, L. Lindholm, T. Ekbom, B. Dahlöf, J. Lanke, B. Scherstén, P. Wester, T. Hedner, U. Faire (1999)
Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 studyThe Lancet, 354
OF CALCIUM*
P. Palatini, W. Jung, E. Shlyakhto, J. Botha, Christopher Bush, D. Keefe (2010)
Maintenance of blood-pressure-lowering effect following a missed dose of aliskiren, irbesartan or ramipril: results of a randomized, double-blind studyJournal of Human Hypertension, 24
K. Jamerson, M. Weber, G. Bakris, B. Dahlöf, B. Pitt, V. Shi, A. Hester, Jitendra Gupte, M. Gatlin, E. Velazquez (2008)
Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients.The New England journal of medicine, 359 23
V. Burt, P. Whelton, E. Roccella, C. Brown, J. Cutler, Millicent Higgins, M. Horan, D. Labarthe (1995)
Prevalence of hypertension in the US adult population. Results from the Third National Health and Nutrition Examination Survey, 1988-1991.Hypertension, 25 3
N. Beckett, R. Peters, A. Fletcher, J. Staessen, Li-sheng Liu, D. Dumitrascu, V. Stoyanovsky, R. Antikainen, Y. Nikitin, C. Anderson, A. Belhani, F. Forette, C. Rajkumar, L. Thijs, W. Banya, C. Bulpitt (2008)
Treatment of hypertension in patients 80 years of age or older.The New England journal of medicine, 358 18
D. Mozaffarian, R. Marfisi, G. Levantesi, M. Silletta, L. Tavazzi, G. Tognoni, F. Valagussa, R. Marchioli (2007)
Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factorsThe Lancet, 370
G. Mancia, G. Backer, A. Dominiczak, R. Cífková, R. Fagard, G. Germano, G. Grassi, A. Heagerty, S. Kjeldsen, S. Laurent, K. Narkiewicz, L. Ruilope, A. Rynkiewicz, R. Schmieder, H. Boudier, A. Zanchetti (2007)
2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)Journal of Hypertension, 25
C. Pepine, E. Handberg, R. Cooper-DeHoff, R. Marks, P. Kowey, F. Messerli, G. Mancia, J. Cangiano, D. García-Barreto, M. Keltai, S. Erdine, Heather Bristol, Ms Kolb, G. Bakris, Jerome Cohen, W. Parmley (2003)
A calcium antagonist vs a non-calcium antagonist hypertension treatment strategy for patients with coronary artery disease. The International Verapamil-Trandolapril Study (INVEST): a randomized controlled trial.JAMA, 290 21
M. Alderman (2003)
The return on INVEST.JAMA, 290 21
Ainah Tan, Brenda Hoffman, Sylvia Rosas (2010)
MORBIDITY AND MORTALITY
D. Sica, W. Frishman (1999)
Hypertension optimal treatment (HOT) study : Successes and failuresCardiovascular reviews and reports, 20
Arya Sharma, H. Wittchen, W. Kirch, D. Pittrow, E. Ritz, B. Göke, H. Lehnert, D. Tschöpe, P. Krause, M. Höfler, H. Pfister, P. Bramlage, T. Unger (2004)
High prevalence and poor control of hypertension in primary care: cross-sectional studyJournal of Hypertension, 22
J. Schrader, S. Lüders, A. Kulschewski, F. Hammersen, K. Plate, J. Berger, W. Zidek, P. Dominiak, H. Diener (2005)
Morbidity and Mortality After Stroke, Eprosartan Compared With Nitrendipine for Secondary Prevention: Principal Results of a Prospective Randomized Controlled Study (MOSES)Stroke, 36
Family Practice—The International Journal for Research in Primary Care
A. Qureshi, M. Suri, Y. Mohammad, L. Guterman, L. Hopkins (2002)
Isolated and Borderline Isolated Systolic Hypertension Relative to Long-Term Risk and Type of Stroke: A 20-Year Follow-Up of the National Health and Nutrition SurveyStroke: Journal of the American Heart Association, 33
W. Aronow, J. Fleg, C. Pepine, N. Artinian, G. Bakris, Alan Brown, K. Ferdinand, M. Forciea, W. Frishman, C. Jaigobin, J. Kostis, G. Mancia, S. Oparil, Eduardo Ortiz, E. Reisin, M. Rich, D. Schocken, M. Weber, D. Wesley, R. Harrington (2011)
ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents.Circulation, 123 21
K. Peterson (2011)
Effects of Intensive Blood-Pressure Control in Type 2 Diabetes MellitusYearbook of Medicine, 2011
G. Mancia, S. Laurent, E. Agabiti-Rosei, E. Ambrosioni, M. Burnier, M. Caulfield, R. Cífková, D. Clement, A. Coca, A. Dominiczak, S. Erdine, R. Fagard, C. Farsang, G. Grassi, H. Haller, A. Heagerty, S. Kjeldsen, W. Kiowski, J. Mallion, A. Manolis, K. Narkiewicz, P. Nilsson, M. Olsen, K. Rahn, J. Redón, J. Rodicio, L. Ruilope, R. Schmieder, H. Struijker-Boudier, P. Zwieten, M. Viigimaa, A. Zanchetti (2009)
Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force documentJournal of Hypertension, 27
H. Lithell, L. Hansson, I. Skoog, D. Elmfeldt, A. Hofman, B. Olofsson, P. Trenkwalder, A. Zanchetti (2003)
The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trialJournal of Hypertension, 21
(2009)
Leitlinien zur Hypertonie
石井當男 (2008)
Principal Results of the Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS)Hypertension Research, 31
G. Mancia, R. Fagard, K. Narkiewicz, J. Redón, A. Zanchetti, M. Böhm, T. Christiaens, R. Cífková, G. Backer, A. Dominiczak, M. Galderisi, D. Grobbee, T. Jaarsma, P. Kirchhof, S. Kjeldsen, S. Laurent, A. Manolis, P. Nilsson, L. Ruilope, R. Schmieder, P. Sirnes, P. Sleight, M. Viigimaa, B. Waeber, F. Zannad (2007)
2013 ESH/ESC Guidelines for the management of arterial hypertensionBlood Pressure, 22
B. Dahlof, B. Devereux, S. Kjeldsen (2002)
Cardiovascular morbidity and mortality in the losartan intervention for end point reduction in hypertension study (LIFE): a randomised trial against atenolol☆Acc Current Journal Review, 11
(1991)
Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research Group.JAMA, 265 24
S. Lewington, R. Clarke, N. Qizilbash, R. Peto, R. Collins (2002)
Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studiesThe Lancet, 360
William Cushman, Gregory Evans, R. Byington, David Goff, Richard Grimm, Jeffrey Cutler, D. Simons-Morton, J. Basile, Marshall Corson, J. Probstfield, Lois Katz, Kevin Peterson, William Friedewald, John Buse, J. Bigger, H. Gerstein, Faramarz Ismail-Beigi (2010)
Effects of intensive blood-pressure control in type 2 diabetes mellitus.The New England journal of medicine, 362 17
(2009)
Swiss Society of Hypertension
P. Verdecchia, J. Staessen, F. Angeli, G. Simone, A. Achilli, A. Ganau, G. Mureddu, S. Pede, A. Maggioni, D. Lucci, G. Reboldi (2009)
Usual versus tight control of systolic blood pressure in non-diabetic patients with hypertension (Cardio-Sis): an open-label randomised trialThe Lancet, 374
(2012)
Bundesgesetz vom 15 Dezember 2000 u ¨ ber Arzneimittel und Medizinprodukte [Federal office in public health Switzerland. Federal act of 15 dec 2000 on drugs and medical devices
W. Elliott (2008)
2007 Guidelines for the Management of Arterial Hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC)Yearbook of Cardiology, 2008
C. Furberg, J. Wright, B. Davis, J. Cutler, M. Alderman, H. Black, W. Cushman, R. Grimm, L. Haywood, F. Leenen, S. Oparil, J. Probstfield, P. Whelton, C. Nwachuku, D. Gordon, M. Proschan, Paula Einhom, C. Ford, L. Piller, I. Dunn, D. Goff, S. Pressel, Judy Bettencourt, Barbara DeLeon, Lara Simpson, J. Blanton, T. Geraci, Sandra Walsh, C. Nelson, Mahboob Rahman, Anne Juratovac, R. Pospíšil, L. Carroll, Sheila Sullivan, J. Russo, G. Barone, Rudy Christian, S. Feldman, T. Lucente, D. Calhoun, Kimo Jenkins, Peggy McDowell, Janice Johnson, C. Kingry, J. Alzate, K. Margolis, Leslie Holland-Klemme, B. Jaeger, J. Williamson, G. Louis, Pamela Ragusa, A. Williard, R. Ferguson, J. Tanner, J. Eckfeldt, R. Crow, J. Pelosi (2002)
Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT).JAMA, 288 23
W. Kannel, R. D’Agostino, H. Silbershatz (1997)
Blood pressure and cardiovascular morbidity and mortality rates in the elderly.American heart journal, 134 4
W. Elliott (2006)
Morbidity and Mortality After Stroke, Eprosartan Compared With Nitrendipine for Secondary Prevention: Principal Results of a Prospective Randomized Controlled Study (MOSES)Yearbook of Cardiology, 2006
(2011)
4 2010 CHEP Recommendations for the Management of Hypertension . http://hypertension.ca/chep/recommendations-2010
S. Julius, S. Kjeldsen, M. Weber, H. Brunner, S. Ekman, L. Hansson, T. Hua, J. Laragh, G. Mcinnes, Lada Mitchell, F. Plat, A. Schork, Beverly Smith, A. Zanchetti (2004)
Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trialThe Lancet, 363
BackgroundThere are only a few trials for the very elderly population (>79 years). No consensus, which blood pressure (BP) goals and substances should be applied, has been found yet. This survey was undertaken to investigate how octogenarians are treated and attain BP targets in the Swiss primary care.MethodsData from 4594 hypertensive patients were collected within 7 days. Eight hundred and seventy-seven patients met the requirement to be >79 years. We assessed substances/combinations and investigated pulse pressure and target blood pressure attainment (TBPA) using three different recommendations [Canadian Hypertension Education Program (CHEP), Swiss Society of Hypertension (SSH), European Society of Hypertension-European Society of Cardiology (ESH-ESC)]. Secondarily, we compared TBPA attained by angiotensin-converting enzyme inhibitor (ACEI)/diuretic (D), angiotensin receptor blocker (ARB)/D and calcium channel blocker (CCB)/D with any other dual therapy and investigated whether Ds/beta-blockers (BBs) or Ds/renin angiotensin-converting enzyme inhibitors (RAAS-Is) lead to higher TBPA. Finally, we assessed the impact of drug administration, practical work experience, location and specialization of GPs on TBPA.ResultsOctogenarians attained target blood pressure (TBP) between 44% (ESH-ESC) and 74% (SSH). Optimal/normal BP was reached in 22.8% of patients. Pulse pressure <65 mmHg was shown in 66.4% of patients. Monotherapy was most commonly applied followed by dual single-pill combination with ARB/D (46.5%) or ACEI/D (36.0%). No benefit in TBPA was found comparing a RAASI/D and CCB/D treatment with any other dual combination. There was also no difference between BB/D and RAAS-I/D combination therapy and between single-pill combination and dual free combinations.ConclusionsGPs adhere to the use of substances proven in outcome trials and attain high TBP. No difference in meeting BP goals could be found using different drug classes. There is an unmet need to harmonize recommendations and to add additional information for the treatment of octogenarians.
Family Practice – Oxford University Press
Published: Oct 29, 2012
Keywords: Europe guidelines hypertension octogenarians Switzerland target blood pressure attainment
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.