Access the full text.
Sign up today, get DeepDyve free for 14 days.
Zongjie Fu, Zhiyu Wang, Lian Xu, Xiao-Hui Chen, Xiang-Xiao Li, Weitang Liao, Hongkun Ma, Mengdi Jiang, Ting-ting Xu, Jing Xu, Yan Shen, B. Song, P. Gao, Wei-Qing Han, Wen Zhang (2020)
HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injuryRedox Biology, 36
Wang (2021)
354Clin Imaging, 69
Youguang Gao, Xingui Dai, Yunfeng Li, Guicheng Li, Xian-zhong Lin, Chenmu Ai, Yuanyuan Cao, Tao Li, Bo Lin (2020)
Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injuryJournal of Translational Medicine, 18
Hailin Zhao, Azeem Alam, Aurelie Soo, A. George, D. Ma (2018)
Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and BeyondEBioMedicine, 28
A. Linkermann, Guochun Chen, Guie Dong, U. Kunzendorf, S. Krautwald, Z. Dong (2014)
Regulated cell death in AKI.Journal of the American Society of Nephrology : JASN, 25 12
Navjotsingh Pabla, Zheng Dong (2008)
Cisplatin nephrotoxicity: mechanisms and renoprotective strategies.Kidney international, 73 9
D. Gatica, Vikramjit Lahiri, D. Klionsky (2018)
Cargo recognition and degradation by selective autophagyNature Cell Biology, 20
Livingston (2019)
2142Autophagy, 15
Katagiri (2016)
374Kidney Int, 89
Zhang (2015)
1590Exp Biol Med (Maywood), 240
Li-Ting Wang, B. Chen, Cheng-Tien Wu, Kuo-How Huang, C. Chiang, Shing Liu (2013)
Protective Role of AMP-Activated Protein Kinase-Evoked Autophagy on an In Vitro Model of Ischemia/Reperfusion-Induced Renal Tubular Cell InjuryPLoS ONE, 8
Man Jiang, Kebin Liu, Jia Luo, Z. Dong (2010)
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury.The American journal of pathology, 176 3
Ying Fu, Chengyuan Tang, Juan Cai, Guochun Chen, Dongshan Zhang, Z. Dong (2018)
Rodent models of AKI-CKD transition.American journal of physiology. Renal physiology, 315 4
L. Su, Jiahao Zhang, H. Gómez, J. Kellum, Z. Peng (2022)
Mitochondria ROS and mitophagy in acute kidney injuryAutophagy, 19
G. Kroemer, G. Mariño, B. Levine (2010)
Autophagy and the integrated stress response.Molecular cell, 40 2
Yuan Zhao, Xiujing Feng, Bei Li, Jichen Sha, Chaoran Wang, Tianyuan Yang, Hailin Cui, H. Fan (2020)
Dexmedetomidine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury by Enhancing Autophagy Through Inhibition of the PI3K/AKT/mTOR PathwayFrontiers in Pharmacology, 11
A. Ozkok, C. Edelstein (2014)
Pathophysiology of Cisplatin-Induced Acute Kidney InjuryBioMed Research International, 2014
Lempiäinen (2013)
410Acta Physiol (Oxf), 208
Shi (2022)
63Kidney Int, 101
Tonghui Xu, Jialin Guo, Maozeng Wei, Jiali Wang, Kehui Yang, C. Pan, J. Pang, L. Xue, Qiu-huan Yuan, Mengyang Xue, Jian Zhang, Wentao Sang, Tangxing Jiang, Yuguo Chen, F. Xu (2021)
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathwayJCI Insight, 6
Qing Shen, Xi Zhang, Qiuying Li, Jing Zhang, Heng Lai, Hua Gan, Xiao-Gang Du, Manli Li (2018)
TLR2 protects cisplatin‐induced acute kidney injury associated with autophagy via PI3K/Akt signaling pathwayJournal of Cellular Biochemistry, 120
Sunahara (2018)
1050Sci Rep, 8
Takagaki (2020)
1905Autophagy, 16
Mingjun Shi, Brianna Flores, Nancy Gillings, A. Bian, Han Cho, Shi-ling Yan, Yang Liu, B. Levine, O. Moe, M. Hu (2016)
αKlotho Mitigates Progression of AKI to CKD through Activation of Autophagy.Journal of the American Society of Nephrology : JASN, 27 8
Kimura (2011)
902J Am Soc Nephrol, 22
Wang (2013)
e79814PLoS One, 8
Zhao (2018)
31EBioMedicine, 28
Kellum (2021)
52Nat Rev Dis Primers, 7
Fu (2018)
F1098Am J Physiol Renal Physiol, 315
Ling Li, Huimin Kang, Qing Zhang, V. D’Agati, Q. Al-Awqati, Fangming Lin (2019)
FoxO3 activation in hypoxic tubules prevents chronic kidney disease.The Journal of clinical investigation, 130
Yang (2008)
F777Am J Physiol Renal Physiol, 294
Yu (2020)
310Curr Opin Nephrol Hypertens, 29
M. Livingston, Shaoqun Shu, Ying Fan, Ze Li, Q. Jiao, X. Yin, M. Venkatachalam, Z. Dong (2022)
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosisAutophagy, 19
D. Katagiri, Y. Hamasaki, Kent Doi, K. Negishi, T. Sugaya, M. Nangaku, E. Noiri (2016)
Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition.Kidney international, 89 2
Sophia Sears, J. Feng, Andrew Orwick, Alexis Vega, A. Krueger, P. Shah, M. Doll, L. Beverly, Leah Siskind (2022)
Pharmacologic inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury.American journal of physiology. Renal physiology
J. Kellum, P. Romagnani, G. Ashuntantang, C. Ronco, A. Zarbock, H. Anders (2021)
Acute kidney injuryNature Reviews Disease Primers, 7
Zhiya Deng, Maomao Sun, Jie Wu, Haihong Fang, Shumin Cai, Sheng An, Qiaobing Huang, Zhenfeng Chen, Chenglun Wu, Ziwei Zhou, Haoran Hu, Z. Zeng (2021)
SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activationCell Death & Disease, 12
N. Shiva, Nisha Sharma, Y. Kulkarni, S. Mulay, A. Gaikwad (2020)
Renal ischemia/reperfusion injury: An insight on in vitro and in vivo models.Life sciences
Shujuan Qiu, Xuexun Chen, Yunyan Pang, Zhaoguang Zhang (2018)
Lipocalin-2 protects against renal ischemia/reperfusion injury in mice through autophagy activation mediated by HIF1α and NF-κb crosstalk.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 108
Man Jiang, Qingqing Wei, Guie Dong, M. Komatsu, Yunchao Su, Z. Dong (2012)
Autophagy in proximal tubules protects against acute kidney injuryKidney international, 82
Fu (2019)
F1582Am J Physiol Renal Physiol, 317
M. Venkatachalam, J. Weinberg, W. Kriz, A. Bidani (2015)
Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression.Journal of the American Society of Nephrology : JASN, 26 8
Liu (2012)
826Autophagy, 8
Gao (2020)
114J Transl Med, 18
Pabla (2011)
2709J Clin Invest, 121
Atsushi Takahashi, Tomonori Kimura, Yoshitsugu Takabatake, T. Namba, J. Kaimori, Harumi Kitamura, I. Matsui, F. Niimura, T. Matsusaka, Naonobu Fujita, T. Yoshimori, Y. Isaka, H. Rakugi (2012)
Cardiovascular , Pulmonary , and Renal Pathology Autophagy Guards Against Cisplatin-Induced Acute Kidney Injury
Sears (2022)
F288Am J Physiol Renal Physiol, 323
Sarah Landau, Xiaojia Guo, H. Velázquez, Richard Torres, Eben Olson, R. Garcia-Milian, G. Moeckel, G. Desir, R. Safirstein (2019)
Regulated necrosis and failed repair in cisplatin-induced chronic kidney disease.Kidney international, 95 4
Lin (2019)
101254Redox Biol, 26
M. Poukkanen, S. Vaara, V. Pettilä, V. Pettilä, K. Kaukonen, A. Korhonen, S. Hovilehto, O. Inkinen, R. Laru-Sompa, T. Kamiński, M. Reinikainen, V. Lund, S. Karlsson (2013)
Acute kidney injury in patients with severe sepsis in Finnish Intensive Care UnitsActa Anaesthesiologica Scandinavica, 57
Chengyuan Tang, Hailong Han, Zhiwen Liu, Yuxue Liu, Lijun Yin, Juan Cai, Liyu He, Yu Liu, Guochun Chen, Zhuohua Zhang, X. Yin, Z. Dong (2019)
Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injuryCell Death & Disease, 10
A Takahashi, T Kimura, Y Takabatake, T Namba, J Kaimori, H Kitamura (2012)
Autophagy guards against cisplatin-induced acute kidney injury, 180
Venkatachalam (2015)
1765J Am Soc Nephrol, 26
D. Ferenbach, J. Bonventre (2015)
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKDNature Reviews Nephrology, 11
Xu
Aldehyde dehydrogenase 2 protects against acute kidney injury by regulating autophagy via the Beclin-1 pathway. JCIInsight, 6
Pabla (2008)
994Kidney Int, 73
N. Mizushima, M. Komatsu (2011)
Autophagy: Renovation of Cells and TissuesCell, 147
Qiu (2018)
244Biomed Pharmacother, 108
Dong-Hyun Kim, J. Park, Hoon‐In Choi, C. Kim, E. Bae, S. Ma, S. Kim (2021)
The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKDCell Death & Disease, 12
Shen (2019)
4366J Cell Biochem, 120
Zhao (2018)
1526Front Physiol, 9
Chengyuan Tang, Hailong Han, Mingjuan Yan, Shiyao Zhu, Jing Liu, Zhiwen Liu, Liyu He, Jieqiong Tan, Yu Liu, Hong Liu, Lin Sun, Shao-bing Duan, Youming Peng, Fuyou Liu, Xiao-Ming Yin, Zhuohua Zhang, Z. Dong (2018)
PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injuryAutophagy, 14
Ying Wang, Chengyuan Tang, Juan Cai, Guochun Chen, Dongshan Zhang, Zhuohua Zhang, Z. Dong (2018)
PINK1/Parkin-mediated mitophagy is activated in cisplatin nephrotoxicity to protect against kidney injuryCell Death & Disease, 9
Wang (2018)
1113Cell Death Dis, 9
Juha Lempiainen, P. Finckenberg, E. Mervaala, S. Sankari, J. Levijoki, J. Levijoki, E. Mervaala (2013)
Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC‐1α–eNOS pathway and enhanced autophagyActa Physiologica, 208
Samuel Yu, J. Bonventre (2020)
Acute kidney injury and maladaptive tubular repair leading to renal fibrosis.Current Opinion in Nephrology & Hypertension
Humphreys (2018)
309Annu Rev Physiol, 80
F. Maremonti, C. Meyer, A. Linkermann (2022)
Mechanisms and Models of Kidney Tubular Necrosis and Nephron Loss.Journal of the American Society of Nephrology : JASN
S. Sunahara, Eizo Watanabe, M. Hatano, P. Swanson, T. Oami, L. Fujimura, Youichi Teratake, Takashi Shimazui, Chiwei Lee, S. Oda (2018)
Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis modelScientific Reports, 8
Zhao (2020)
128Front Pharmacol, 11
Landau (2019)
797Kidney Int, 95
B. Humphreys (2018)
Mechanisms of Renal Fibrosis.Annual review of physiology, 80
Wang (2021)
101767Redox Biol, 38
Tang (2019)
677Cell Death Dis, 10
Palaniyandi Ravanan, Ida Srikumar, P. Talwar (2017)
Autophagy: The spotlight for cellular stress responses.Life sciences, 188
Jiang (2010)
1181Am J Pathol, 176
Li Li, H. Fu, Youhua Liu (2022)
The fibrogenic niche in kidney fibrosis: components and mechanismsNature Reviews Nephrology, 18
J. Decuypere, Shawn Hutchinson, D. Monbaliu, W. Martinet, J. Pirenne, I. Jochmans (2020)
Autophagy Dynamics and Modulation in a Rat Model of Renal Ischemia-Reperfusion InjuryInternational Journal of Molecular Sciences, 21
Navjotsingh Pabla, Guie Dong, Man Jiang, Shuang Huang, M. Kumar, Robert Messing, Z. Dong (2011)
Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.The Journal of clinical investigation, 121 7
Liu (2020)
183Nat Rev Mol Cell Biol, 21
Gatica (2018)
233Nat Cell Biol, 20
Chuanyan Zhao, Zhuyun Chen, Xueqiang Xu, Xiaofei An, S. Duan, Zhi-min Huang, Chengning Zhang, Lin Wu, Bo Zhang, A. Zhang, C. Xing, Yanggang Yuan (2017)
Pink1/Parkin‐mediated mitophagy play a protective role in cisplatin induced renal tubular epithelial cells injuryExperimental Cell Research, 350
Li (2022)
545Nat Rev Nephrol, 18
Mapuskar (2019)
98Redox Biol, 20
Li (2019)
2374J Clin Invest, 129
Zhao (2017)
390Exp Cell Res, 350
Fu (2020)
101671Redox Biol, 36
Lin (2021)
2975Autophagy, 17
Adi Abada, Z. Elazar (2014)
Getting ready for building: signaling and autophagosome biogenesisEMBO reports, 15
A. Baisantry, Sagar Bhayana, S. Rong, Esther Ermeling, C. Wrede, J. Hegermann, P. Pennekamp, I. Sörensen-Zender, H. Haller, A. Melk, R. Schmitt (2016)
Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments.Journal of the American Society of Nephrology : JASN, 27 6
B. Chandrika, Cheng Yang, Y. Ou, Xiaoke Feng, D. Muhoza, Alexandrea Holmes, S. Theus, S. Deshmukh, R. Haun, G. Kaushal (2015)
Endoplasmic Reticulum Stress-Induced Autophagy Provides Cytoprotection from Chemical Hypoxia and Oxidant Injury and Ameliorates Renal Ischemia-Reperfusion InjuryPLoS ONE, 10
S. Periyasamy‐Thandavan, Man Jiang, Qingqing Wei, Robert Smith, Xiao-Ming Yin, Z. Dong (2008)
Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells.Kidney international, 74 5
D. Basile, J. Bonventre, R. Mehta, M. Nangaku, R. Unwin, M. Rosner, J. Kellum, C. Ronco (2016)
Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments.Journal of the American Society of Nephrology : JASN, 27 3
Jiang (2012)
1271Kidney Int, 82
Y. Takagaki, Seon Lee, Z. Dongqing, Munehiro Kitada, Keizo Kansaki, D. Koya (2020)
Endothelial autophagy deficiency induces IL6 - dependent endothelial mesenchymal transition and organ fibrosisAutophagy, 16
Wen‐yu Zhao, Lei Zhang, R. Chen, Hanlan Lu, Mingxing Sui, You‐hua Zhu, L. Zeng (2018)
SIRT3 Protects Against Acute Kidney Injury via AMPK/mTOR-Regulated AutophagyFrontiers in Physiology, 9
Wang (2020)
619730Front Physiol, 11
Sun (2018)
2247Circulation, 138
Ying Fu, Y. Xiang, Wenwen Wu, Juan Cai, Chengyuan Tang, Z. Dong (2022)
Persistent Activation of Autophagy After Cisplatin Nephrotoxicity Promotes Renal Fibrosis and Chronic Kidney DiseaseFrontiers in Pharmacology, 13
Volarevic (2019)
25J Biomed Sci, 26
Poukkanen (2013)
863Acta Anaesthesiol Scand, 57
Baisantry (2016)
1609J Am Soc Nephrol, 27
H. Gómez, J. Kellum (2016)
Sepsis-induced acute kidney injuryCurrent Opinion in Critical Care, 22
Jisun Lee, S. Giordano, Jianhua Zhang (2011)
Autophagy, mitochondria and oxidative stress: cross-talk and redox signallingBiochemical Journal, 441
Ying Wang, Jiefu Zhu, Zhiwen Liu, Shaoqun Shu, Ying Fu, Yuxue Liu, Juan Cai, Chengyuan Tang, Yu Liu, X. Yin, Z. Dong (2020)
The PINK1/PARK2/optineurin pathway of mitophagy is activated for protection in septic acute kidney injuryRedox Biology, 38
S. Djudjaj, P. Boor (2019)
Cellular and molecular mechanisms of kidney fibrosis.Molecular aspects of medicine, 65
Kim (2021)
320Cell Death Dis, 12
Jin Wang, Pingjun Zhu, Ruibing Li, Jun Ren, Hao Zhou (2019)
Fundc1-dependent mitophagy is obligatory to ischemic preconditioning-conferred renoprotection in ischemic AKI via suppression of Drp1-mediated mitochondrial fissionRedox Biology, 30
Grace Liu, D. Sabatini (2020)
mTOR at the nexus of nutrition, growth, ageing and diseaseNature Reviews Molecular Cell Biology, 21
G. Canaud, C. Brooks, S. Kishi, K. Taguchi, K. Nishimura, S. Magassa, Adam Scott, L. Hsiao, T. Ichimura, F. Terzi, Li Yang, J. Bonventre (2019)
Cyclin G1 and TASCC regulate kidney epithelial cell G2-M arrest and fibrotic maladaptive repairScience Translational Medicine, 11
Tomonori Kimura, Yoshitsugu Takabatake, Atsushi Takahashi, J. Kaimori, I. Matsui, T. Namba, Harumi Kitamura, F. Niimura, T. Matsusaka, T. Soga, H. Rakugi, Y. Isaka (2011)
Autophagy protects the proximal tubule from degeneration and acute ischemic injury.Journal of the American Society of Nephrology : JASN, 22 5
Periyasamy-Thandavan (2008)
631Kidney Int, 74
Kimura (2012)
1093Kidney Int, 82
Chengyuan Tang, Juan Cai, Xiaolin Yin, J. Weinberg, M. Venkatachalam, Z. Dong (2020)
Mitochondrial quality control in kidney injury and repairNature Reviews Nephrology, 17
Yi Wang, Kaixiang Liu, Xisheng Xie, B. Song (2020)
Contrast-associated acute kidney injury: An update of risk factors, risk factor scores, and preventive measures.Clinical imaging, 69
Q. Lin, Shu Li, N. Jiang, Haijiao Jin, Xinghua Shao, Xuying Zhu, Jingkui Wu, Min-fang Zhang, Zhen Zhang, Jianxiao Shen, Wenyan Zhou, L. Gu, R. Lu, Z. Ni (2020)
Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagyAutophagy, 17
Mingjun Shi, Jenny Maique, Sierra Shepard, Peng Li, Olivia Seli, O. Moe, Ming Hu (2021)
In vivo evidence for therapeutic applications of beclin 1 to promote recovery and inhibit fibrosis after acute kidney injury.Kidney international
Lamb (2013)
759Nat Rev Mol Cell Biol, 14
Shuya Liu, B. Hartleben, O. Kretz, T. Wiech, P. Igarashi, N. Mizushima, G. Walz, T. Huber (2012)
Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injuryAutophagy, 8
Abada (2014)
839EMBO Rep, 15
Basile (2016)
687J Am Soc Nephrol, 27
Ying Wang, Zhiwen Liu, Shaoqun Shu, Juan Cai, Chengyuan Tang, Z. Dong (2020)
AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney InjuryFrontiers in Physiology, 11
Deng (2021)
217Cell Death Dis, 12
Gómez (2016)
546Curr Opin Crit Care, 22
Ravanan (2017)
53Life Sci, 188
Ferenbach (2015)
264Nat Rev Nephrol, 11
Li (2016)
1472Autophagy, 12
Li Gong, Jin He, Xieyi Sun, Lanlan Li, Xi Zhang, Hua Gan (2020)
Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 125
Bellomo (2017)
816Intensive Care Med, 43
Takahashi (2012)
517Am J Pathol, 180
M. Livingston, Jinghong Wang, Jiliang Zhou, Guangyu Wu, I. Ganley, Joseph Hill, Xiao-Ming Yin, Z. Dong (2019)
Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneysAutophagy, 15
Q. Lin, Shu Li, N. Jiang, Xinghua Shao, Min-fang Zhang, Haijiao Jin, Zhen Zhang, Jianxiao Shen, Yijun Zhou, Wenyan Zhou, L. Gu, R. Lu, Z. Ni (2019)
PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activationRedox Biology, 26
Chandrika (2015)
e0140025PLoS One, 10
Maremonti (2022)
472J Am Soc Nephrol, 33
Mizushima (2011)
728Cell, 147
Wang (2020)
101415Redox Biol, 30
Ying Fu, Juan Cai, Fanghua Li, Zhiwen Liu, Shaoqun Shu, Ying Wang, Yuxue Liu, Chengyuan Tang, Z. Dong (2019)
Chronic effects of repeated low dose cisplatin treatment in mouse kidneys and renal tubular cells.American journal of physiology. Renal physiology
V. Volarevic, Bojana Djokovic, M. Jankovic, C. Harrell, Crissy Fellabaum, V. Djonov, N. Arsenijević (2019)
Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicityJournal of Biomedical Science, 26
Shuqin Mei, M. Livingston, Jielu Hao, Lin Li, C. Mei, Z. Dong (2016)
Autophagy is activated to protect against endotoxic acute kidney injuryScientific Reports, 6
Ya-Li Zhang, Jie Zhang, L. Cui, Shuo Yang (2015)
Autophagy activation attenuates renal ischemia-reperfusion injury in ratsExperimental Biology and Medicine, 240
Djudjaj (2019)
16Mol Asp Med, 65
Kroemer (2010)
280Mol Cell, 40
Lee (2012)
523Biochem J, 441
Zeping Gui, C. Suo, Zi-jie Wang, M. Zheng, S. Fei, Hao Chen, Li Sun, Zhijian Han, J. Tao, Xiao-bing Ju, Haiwei Yang, M. Gu, R. Tan (2021)
Impaired ATG16L-Dependent Autophagy Promotes Renal Interstitial Fibrosis in Chronic Renal Graft Dysfunction Through Inducing EndMT by NF-κB Signal PathwayFrontiers in Immunology, 12
Shi (2016)
2331J Am Soc Nephrol, 27
K. Mapuskar, Hsiang Wen, D. Holanda, P. Rastogi, E. Steinbach, Rachel Han, M. Coleman, M. Attanasio, D. Riley, D. Spitz, B. Allen, D. Zepeda-Orozco (2018)
Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney diseaseRedox Biology, 20
Ozkok (2014)
1Biomed Res Int, 2014
Tang (2021)
299Nat Rev Nephrol, 17
Yuxiao Sun, X. Yao, Qing-Jun Zhang, Min Zhu, Zhi-ping Liu, B. Ci, Yang Xie, D. Carlson, B. Rothermel, Yuxiang Sun, B. Levine, Joseph Hill, S. Wolf, J. Minei, Q. Zang (2018)
Beclin-1-Dependent Autophagy Protects the Heart During SepsisCirculation, 138
A. Kimura, Y. Ishida, M. Inagaki, Yasushi Nakamura, T. Sanke, N. Mukaida, T. Kondo (2012)
Interferon-γ is protective in cisplatin-induced renal injury by enhancing autophagic flux.Kidney international, 82 10
Gui (2021)
650424Front Immunol, 12
Fu (2022)
918732Front Pharmacol, 13
Inhibit - ing NLRP 3 inflammasome attenuates
Gong (2020)
110021Biomed Pharmacother, 125
R. Bellomo, J. Kellum, C. Ronco, R. Wald, J. Mårtensson, Matthew Maiden, S. Bagshaw, N. Glassford, Yugeesh Lankadeva, S. Vaara, A. Schneider (2017)
Acute kidney injury in sepsisIntensive Care Medicine, 43
Cheng Yang, V. Kaushal, Sudhir Shah, G. Kaushal (2008)
Autophagy is associated with apoptosis in cisplatin injury to renal tubular epithelial cells.American journal of physiology. Renal physiology, 294 4
Linkermann (2014)
2689J Am Soc Nephrol, 25
Tang (2018)
880Autophagy, 14
Huiyan Li, X. Peng, Yating Wang, Shirong Cao, Li-ping Xiong, Jin-jin Fan, Yihan Wang, S. Zhuang, Xueqing Yu, H. Mao (2016)
Atg5-mediated autophagy deficiency in proximal tubules promotes cell cycle G2/M arrest and renal fibrosisAutophagy, 12
C. Lamb, T. Yoshimori, S. Tooze (2013)
The autophagosome: origins unknown, biogenesis complexNature Reviews Molecular Cell Biology, 14
Shiva (2020)
117860Life Sci, 256
Acute kidney injury (AKI) is a major renal disease characterized by a sudden decrease in kidney function. After AKI, the kidney has the ability to repair, but if the initial injury is severe the repair may be incomplete or maladaptive and result in chronic kidney problems. Autophagy is a highly conserved pathway to deliver intracellular contents to lysosomes for degradation. Autophagy plays an important role in maintaining renal function and is involved in the pathogenesis of renal diseases. Autophagy is activated in various forms of AKI and acts as a defense mechanism against kidney cell injury and death. After AKI, autophagy is maintained at a relatively high level in kidney tubule cells during maladaptive kidney repair but the role of autophagy in maladaptive kidney repair has been controversial. Nonetheless, recent studies have demonstrated that autophagy may contribute to maladaptive kidney repair after AKI by inducing tubular degeneration and promoting a profibrotic phenotype in renal tubule cells. In this review, we analyze the role and regulation of autophagy in kidney injury and repair and discuss the therapeutic strategies by targeting autophagy.
Burns & Trauma – Oxford University Press
Published: Jan 22, 2023
Keywords: Autophagy; Acute kidney injury; Maladaptive repair; Fibrosis; Chronic kidney disease
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.