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S. Amiel (2009)
Hypoglycemia: From the Laboratory to the ClinicDiabetes Care, 32
L. Donnelly, A. Morris, B. Frier, J. Ellis, P. Donnan, R. Durrant, M. Band, G. Reekie, G. Leese (2005)
Frequency and predictors of hypoglycaemia in Type 1 and insulin‐treated Type 2 diabetes: a population‐based studyDiabetic Medicine, 22
N. Müller, R. Schiel, B. Osterbrink, R. Holl, W. Kerner, H. Hauner, P. Beyer, H. Hoyer, J. Krug, U. Müller (2008)
Behandlungsqualität von Patienten mit Diabetes mellitus Typ 1 und Typ 2 in Schwerpunktpraxis, Diabetesfachklinik und Akutkrankenhaus in der Bundesrepublik Deutschland 2005: Auswertung der Zertifizierungsdaten zur Diabeteseinrichtung DDG1Diabetologie und Stoffwechsel, 3
P. Cryer (2008)
The Barrier of Hypoglycemia in DiabetesDiabetes, 57
A. Holstein, A. Plaschke, E. Egberts (2003)
Clinical characterisation of severe hypoglycaemia--a prospective population-based study.Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 111 6
Anushka Patel, S. MacMahon, J. Chalmers, B. Neal, L. Billot, M. Woodward, M. Marre, M. Cooper, P. Glasziou, D. Grobbee, P. Hamet, S. Harrap, S. Heller, Li-sheng Liu, G. Mancia, C. Mogensen, C. Pan, N. Poulter, A. Rodgers, B. Williams, Severine Bompoint, B. Galan, R. Joshi, F. Travert (2008)
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes.The New England journal of medicine, 358 24
A. Sämann, O. Tajiyeva, N. Müller, T. Tschauner, H. Hoyer, G. Wolf, U. Müller (2008)
Prevalence of the diabetic foot syndrome at the primary care level in Germany: a cross‐sectional studyDiabetic Medicine, 25
S. Amiel, S. Beveridge, C. Bradley, C. Gianfrancesco, S. Heller, Peter James, N. McKeown, Douglas Newton, L. Newton, L. Oliver, H. Reid, S. Roberts, Sue Robson, J. Rollingson, V. Scott, J. Speight, Carolin Taylor, G. Thompson, E. Turner, Frances Wright (2002)
Training in flexible, intensive insulin management to enable dietary freedom in people with type 1 diabetes: dose adjustment for normal eating (DAFNE) randomised controlled trialBMJ : British Medical Journal, 325
Diabetes Control, D. Nathan, S. Genuth, J. Lachin, P. Cleary, O. Crofford, M. Davis, L. Rand, C. Siebert (1993)
The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long‐Term Complications in Insulin‐Dependent Diabetes MellitusSurvey of Anesthesiology, 38
R. Team (2014)
R: A language and environment for statistical computing.MSOR connections, 1
Ingrid Mühlhauser, H. Overmann, R. Bender, U. Bott, M. Berger (1998)
Risk factors of severe hypoglycaemia in adult patients with Type I diabetes – a prospective population based studyDiabetologia, 41
A. Sämann, I. Mühlhauser, R. Bender, C. Kloos, U. Müller (2005)
Glycaemic control and severe hypoglycaemia following training in flexible, intensive insulin therapy to enable dietary freedom in people with type 1 diabetes: a prospective implementation studyDiabetologia, 48
Workgroup Hypoglycemia (2005)
Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia.Diabetes care, 28 5
B. Parekh (2009)
Mechanisms of the Blunting of the Sympatho-Adrenal Response: A TheoryCurrent Diabetes Reviews, 5
S. Bott, U. Bott, M. Berger, I. Mühlhauser (1997)
Intensified insulin therapy and the risk of severe hypoglycaemiaDiabetologia, 40
P. Cryer (2000)
Are gender differences in the responses to hypoglycemia relevant to iatrogenic hypoglycemia in type 1 diabetes?The Journal of clinical endocrinology and metabolism, 85 6
Stephanie Amiel (1993)
Intensified insulin therapy.Diabetes/metabolism reviews, 9 1
R. Turner, C. Fox, Matthews, H. Mcelroy, C. Cull, R. Holman, P. Neil, D. Hadden, D. Wright, É. Manley, I. Stratton, Uk Diabetes, E. Kohner, Frighi, Michael Gnant (1998)
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group.The Lancet
Jacques Baillargeon (2001)
Characteristics of the healthy worker effect.Occupational medicine, 16 2
U. Pedersen-Bjergaard, S. Pramming, S. Heller, T. Wallace, Å. Rasmussen, H. Jørgensen, D. Matthews, P. Hougaard, B. Thorsteinsson (2004)
Severe hypoglycaemia in 1076 adult patients with type 1 diabetes: influence of risk markers and selectionDiabetes/Metabolism Research and Reviews, 20
J. Schulze, U. Rothe, G. Müller, H. Kunath (2003)
Verbesserung der Versorgung von Diabetikern durch das sächsische BetreuungsmodellDeutsche Medizinische Wochenschrift, 128
A. Levey, L. Stevens, C. Schmid, Y. Zhang, Alejandro Castro, H. Feldman, J. Kusek, P. Eggers, F. Lente, T. Greene, J. Coresh (2009)
A new equation to estimate glomerular filtration rate.Annals of internal medicine, 150 9
Aims.To investigate the incidence and risk factors of severe hypoglycemia (SH) in primary care. SH was defined as hypoglycemia with coma, or the need of glucose or glucagon injection.Methods.We performed a cross-sectional retrospective study in patients with diabetes treated in primary care in Germany. We analyzed an unselected sample of participants with type 1 (n = 373) and type 2 diabetes (n = 4481) who participated in an insurance plan from the health care insurer Deutsche BKK. Data of participants with type 1 diabetes are as follows: women, n = 155 (42%); age, 49±16 years; diabetes duration, 20+13 years; BMI, 28±6kg/m²; GHb, 7.1+1.5%; GHb≤7%, n = 263 (71%); GHb≥8.5%, n = 48 (13%). Data of participants with type 2 diabetes: women, n = 1979 (44%); age, 66±10 years; diabetes duration, 8±7 years; BMI, 30±5kg/m²; GHb, 6.6±1.3%; GHb≤7%, n = 3747 (84%); GHb≥8.5%, n = 360 (8%); insulin therapy, n = 1175 (26%).Results.The incidence of SH in type 1 diabetes: 1.3% (CI: 0.4%, 3.1%) per year; type 2 diabetes with insulin therapy: 0.9% (CI: 0.5%, 1.7%); without insulin therapy: 0.3% (CI: 0.1%, 0.6%). The event rate was 0.02 SH per patient/year in type 1 diabetes and 0.01 in type 2 diabetes, respectively. Low BMI, GHb, insulin therapy and female gender were associated with an increased risk of SH.Conclusions.In primary care, patients with diabetes can achieve good glycemic control with very rare events of SH. Due to low incidence, SH would have been an inappropriate parameter to evaluate the outcome quality of diabetes therapy in primary care.
Family Practice – Oxford University Press
Published: Jun 19, 2013
Keywords: Key words. Diabetes mellitus primary care severe hypoglycemia.
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