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Usefulness and Applicability of Integrated Strategy Approaches in Toxicology

Usefulness and Applicability of Integrated Strategy Approaches in Toxicology APPLIED IN VITRO TOXICOLOGY INTRODUCTION TO THE SPECIAL ISSUE Volume 7, Number 3, 2021 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2021.0021 Usefulness and Applicability of Integrated Strategy Approaches in Toxicology 1,i 2 3 4 Chantra Eskes, Silvia Casati, Nicole Kleinstreuer, and Janine Ezendam t is generally accepted that more than one method is which describe a mechanistic sequence of events starting I necessary to mimic the complexity of mechanistic events with a molecular initiating event, progressing through inter- that lead to adverse effects in living organisms such as mediate key events and ultimately leading to an adverse out- human beings. Furthermore, in the EU, the directive on the come (https://aopwiki.org). This ensures the mechanistic protection of animals used for experimental and other scien- coverage of the molecular and cellular events leading to the tific purposes (Directive 86/609/EEC replaced by Directive predicted adverse effect. 2010/63/EU) has, as a final goal, the full replacement of pro- Recent applications of these approaches in regulatory safety cedures on live animals for scientific and educational pur- assessment include the use of AOP for the assessment of skin poses as soon as it is scientifically possible. sensitization (OECD GD 168), and the use of IATA http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied In Vitro Toxicology Mary Ann Liebert

Usefulness and Applicability of Integrated Strategy Approaches in Toxicology

Usefulness and Applicability of Integrated Strategy Approaches in Toxicology

Applied In Vitro Toxicology , Volume 7 (3): 2 – Sep 1, 2021

Abstract

APPLIED IN VITRO TOXICOLOGY INTRODUCTION TO THE SPECIAL ISSUE Volume 7, Number 3, 2021 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2021.0021 Usefulness and Applicability of Integrated Strategy Approaches in Toxicology 1,i 2 3 4 Chantra Eskes, Silvia Casati, Nicole Kleinstreuer, and Janine Ezendam t is generally accepted that more than one method is which describe a mechanistic sequence of events starting I necessary to mimic the complexity of mechanistic events with a molecular initiating event, progressing through inter- that lead to adverse effects in living organisms such as mediate key events and ultimately leading to an adverse out- human beings. Furthermore, in the EU, the directive on the come (https://aopwiki.org). This ensures the mechanistic protection of animals used for experimental and other scien- coverage of the molecular and cellular events leading to the tific purposes (Directive 86/609/EEC replaced by Directive predicted adverse effect. 2010/63/EU) has, as a final goal, the full replacement of pro- Recent applications of these approaches in regulatory safety cedures on live animals for scientific and educational pur- assessment include the use of AOP for the assessment of skin poses as soon as it is scientifically possible. sensitization (OECD GD 168), and the use of IATA

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Publisher
Mary Ann Liebert
Copyright
Copyright 2021, Mary Ann Liebert, Inc., publishers
ISSN
2332-1512
eISSN
2332-1539
DOI
10.1089/aivt.2021.0021
Publisher site
See Article on Publisher Site

Abstract

APPLIED IN VITRO TOXICOLOGY INTRODUCTION TO THE SPECIAL ISSUE Volume 7, Number 3, 2021 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2021.0021 Usefulness and Applicability of Integrated Strategy Approaches in Toxicology 1,i 2 3 4 Chantra Eskes, Silvia Casati, Nicole Kleinstreuer, and Janine Ezendam t is generally accepted that more than one method is which describe a mechanistic sequence of events starting I necessary to mimic the complexity of mechanistic events with a molecular initiating event, progressing through inter- that lead to adverse effects in living organisms such as mediate key events and ultimately leading to an adverse out- human beings. Furthermore, in the EU, the directive on the come (https://aopwiki.org). This ensures the mechanistic protection of animals used for experimental and other scien- coverage of the molecular and cellular events leading to the tific purposes (Directive 86/609/EEC replaced by Directive predicted adverse effect. 2010/63/EU) has, as a final goal, the full replacement of pro- Recent applications of these approaches in regulatory safety cedures on live animals for scientific and educational pur- assessment include the use of AOP for the assessment of skin poses as soon as it is scientifically possible. sensitization (OECD GD 168), and the use of IATA

Journal

Applied In Vitro ToxicologyMary Ann Liebert

Published: Sep 1, 2021

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