Abstract

APPLIED IN VITRO TOXICOLOGY ROUNDTABLE DISCUSSION Volume 1, Number 4, 2015 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2015.29002.rtl The Promise and Potential of ‘‘Organs-on-Chips’’ as Preclinical Models Moderator: Anthony Bahinski, PhD, MBA, FAHA 2 3 4 Participants: Reyk Horland, PhD, Dan Huh, PhD, Christine Mummery, PhD, 5 6,* Danilo A. Tagle, PhD, and Tracy MacGill, PhD Introduction channels are perfused with culture medium to provide cells with nutrients, oxygen, and other soluble factors critical for evelopment of safe and effective drugs is currently cell growth and differentiation. Dhampered by the poor predictive power of existing pre- Virtually, all human organs consist of multiple types of clinical animal models that often lead to failure of drug com- tissue and they self-assemble into various patterns to create pounds late in their development. This roundtable brings interesting 3D structures and microarchitecture in a very together experts in the field of microphysiological systems, organ-specific manner. One of the key design requirements stem cell biology, as well as governmental and regulatory for human organ-chip devices is to mimic these organ- thought leaders to discuss the development and potential util- specific tissue structures and biological interfaces between ity of human ‘‘organs-on-chips’’ as preclinical models for