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The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter Function, and the Best Models for Future In Vitro Testing

The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter... APPLIED IN VITRO TOXICOLOGY ROUNDTABLE DISCUSSION Volume 2, Number 1, 2016 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2016.29004.rtl The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter Function, and the Best Models for Future In Vitro Testing Moderator: Kenneth R. Brouwer, PhD, RPh 2 3 4 Participants: Stephen S. Ferguson, PhD, Yurong Lai, PhD, Gang Luo, PhD, 5 6, 7 Amy L. Roe, PhD, DABT, Donna A. Volpe, PhD, and Kyunghee Yang, PhD Introduction The third area is the bidirectional transport assays, which are usually in polarized cell monolayers, such as Caco-2. You can panel of experts, hosted by Applied In Vitro Toxicol- use those to study efflux transporters or the interplay between Aogy, discuss the various types of liver models that are uptake and efflux transporters. Usually, they are seated on a per- used for transport studies with a focus on the utility of having meable membrane and form a very tight cell monolayer. a system with functional uptake and efflux transporters. One important considerationfor these types of cells, espe- cially if you are looking at an efflux transporter, is that com- Dr. Kenneth R. Brouwer: To start, I will describe some of pounds need http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied In Vitro Toxicology Mary Ann Liebert

The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter Function, and the Best Models for Future In Vitro Testing

The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter Function, and the Best Models for Future In Vitro Testing

Applied In Vitro Toxicology , Volume 2 (1): 7 – Mar 1, 2016

Abstract

APPLIED IN VITRO TOXICOLOGY ROUNDTABLE DISCUSSION Volume 2, Number 1, 2016 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2016.29004.rtl The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter Function, and the Best Models for Future In Vitro Testing Moderator: Kenneth R. Brouwer, PhD, RPh 2 3 4 Participants: Stephen S. Ferguson, PhD, Yurong Lai, PhD, Gang Luo, PhD, 5 6, 7 Amy L. Roe, PhD, DABT, Donna A. Volpe, PhD, and Kyunghee Yang, PhD Introduction The third area is the bidirectional transport assays, which are usually in polarized cell monolayers, such as Caco-2. You can panel of experts, hosted by Applied In Vitro Toxicol- use those to study efflux transporters or the interplay between Aogy, discuss the various types of liver models that are uptake and efflux transporters. Usually, they are seated on a per- used for transport studies with a focus on the utility of having meable membrane and form a very tight cell monolayer. a system with functional uptake and efflux transporters. One important considerationfor these types of cells, espe- cially if you are looking at an efflux transporter, is that com- Dr. Kenneth R. Brouwer: To start, I will describe some of pounds need

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Mary Ann Liebert
Copyright
Copyright 2016, Mary Ann Liebert, Inc.
ISSN
2332-1512
eISSN
2332-1539
DOI
10.1089/aivt.2016.29004.rtl
Publisher site
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Abstract

APPLIED IN VITRO TOXICOLOGY ROUNDTABLE DISCUSSION Volume 2, Number 1, 2016 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2016.29004.rtl The Importance of In Vitro Liver Models: Experts Discuss Whole-Cell Systems, Transporter Function, and the Best Models for Future In Vitro Testing Moderator: Kenneth R. Brouwer, PhD, RPh 2 3 4 Participants: Stephen S. Ferguson, PhD, Yurong Lai, PhD, Gang Luo, PhD, 5 6, 7 Amy L. Roe, PhD, DABT, Donna A. Volpe, PhD, and Kyunghee Yang, PhD Introduction The third area is the bidirectional transport assays, which are usually in polarized cell monolayers, such as Caco-2. You can panel of experts, hosted by Applied In Vitro Toxicol- use those to study efflux transporters or the interplay between Aogy, discuss the various types of liver models that are uptake and efflux transporters. Usually, they are seated on a per- used for transport studies with a focus on the utility of having meable membrane and form a very tight cell monolayer. a system with functional uptake and efflux transporters. One important considerationfor these types of cells, espe- cially if you are looking at an efflux transporter, is that com- Dr. Kenneth R. Brouwer: To start, I will describe some of pounds need

Journal

Applied In Vitro ToxicologyMary Ann Liebert

Published: Mar 1, 2016

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