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Precision Cut Lung Slices as a Model for 3R Application in Toxicology

Precision Cut Lung Slices as a Model for 3R Application in Toxicology APPLIED IN VITRO TOXICOLOGY COMMENTARY Volume 6, Number 2, 2020 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2020.29025.com Precision Cut Lung Slices as a Model for 3R Application in Toxicology Julia Herbert and Andrew Gow ethodologies in toxicological research presently All organ slices, including PCLS, are three-dimensional M rely heavily on in vivo approaches. Since ethical excerpts of the actual organ, comprising all resident cell considerations forbid human testing in most cases, animal types alongside their physiological structural and functional studies are employed as a close depiction of human patho- interactions. Allowing one to reserve the microenvironment physiology. Controversy on the value of data obtained of the cell, while considering its response to exposure. The from in vivo study is ongoing, especially with regard to possible applications for toxicology research alone are translatability. Still, a considerable number of animal- manifold. PCLS have been employed for studies on airway based studies are conducted in basic research, industry, responsiveness, immunotoxicity, neurotoxicity, genotoxic- 3–6 and the pharmaceutical sector, in part required by law. ity, andmanymore. Commonly, toxicological endpoints The current situation makes ex vivo and in vitro approaches comprise airway contractility, cellular viability after expo- take a back seat, despite the fact that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied In Vitro Toxicology Mary Ann Liebert

Precision Cut Lung Slices as a Model for 3R Application in Toxicology

Applied In Vitro Toxicology , Volume 6 (2): 2 – Jun 1, 2020

Precision Cut Lung Slices as a Model for 3R Application in Toxicology

Applied In Vitro Toxicology , Volume 6 (2): 2 – Jun 1, 2020

Abstract

APPLIED IN VITRO TOXICOLOGY COMMENTARY Volume 6, Number 2, 2020 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2020.29025.com Precision Cut Lung Slices as a Model for 3R Application in Toxicology Julia Herbert and Andrew Gow ethodologies in toxicological research presently All organ slices, including PCLS, are three-dimensional M rely heavily on in vivo approaches. Since ethical excerpts of the actual organ, comprising all resident cell considerations forbid human testing in most cases, animal types alongside their physiological structural and functional studies are employed as a close depiction of human patho- interactions. Allowing one to reserve the microenvironment physiology. Controversy on the value of data obtained of the cell, while considering its response to exposure. The from in vivo study is ongoing, especially with regard to possible applications for toxicology research alone are translatability. Still, a considerable number of animal- manifold. PCLS have been employed for studies on airway based studies are conducted in basic research, industry, responsiveness, immunotoxicity, neurotoxicity, genotoxic- 3–6 and the pharmaceutical sector, in part required by law. ity, andmanymore. Commonly, toxicological endpoints The current situation makes ex vivo and in vitro approaches comprise airway contractility, cellular viability after expo- take a back seat, despite the fact that

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Publisher
Mary Ann Liebert
Copyright
Copyright 2020, Mary Ann Liebert, Inc., publishers
ISSN
2332-1512
eISSN
2332-1539
DOI
10.1089/aivt.2020.29025.com
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Abstract

APPLIED IN VITRO TOXICOLOGY COMMENTARY Volume 6, Number 2, 2020 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2020.29025.com Precision Cut Lung Slices as a Model for 3R Application in Toxicology Julia Herbert and Andrew Gow ethodologies in toxicological research presently All organ slices, including PCLS, are three-dimensional M rely heavily on in vivo approaches. Since ethical excerpts of the actual organ, comprising all resident cell considerations forbid human testing in most cases, animal types alongside their physiological structural and functional studies are employed as a close depiction of human patho- interactions. Allowing one to reserve the microenvironment physiology. Controversy on the value of data obtained of the cell, while considering its response to exposure. The from in vivo study is ongoing, especially with regard to possible applications for toxicology research alone are translatability. Still, a considerable number of animal- manifold. PCLS have been employed for studies on airway based studies are conducted in basic research, industry, responsiveness, immunotoxicity, neurotoxicity, genotoxic- 3–6 and the pharmaceutical sector, in part required by law. ity, andmanymore. Commonly, toxicological endpoints The current situation makes ex vivo and in vitro approaches comprise airway contractility, cellular viability after expo- take a back seat, despite the fact that

Journal

Applied In Vitro ToxicologyMary Ann Liebert

Published: Jun 1, 2020

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