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Multiple Approaches to Understanding the Toxic Dose

Multiple Approaches to Understanding the Toxic Dose APPLIED IN VITRO TOXICOLOGY EDITORIAL Volume 7, Number 4, 2021 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2021.29025.edi Andrew Gow ne of the principal challenges in all of toxicology sequential metabolisms across a range of cells. Thus the Ois the importance of dose. We are all familiar with the complexity of systems that can be evaluated for toxicity phrase, attributed to Paracelsus, that everything is a poison, in vitro is increased. it is just the dose that counts. However, we have seen that Even with systems such as the Waterfall, where we can dose is not just a linear construct such that a particular streamline complex toxicological assessment, there is still value is toxic. Rather we must consider the situation regard- a lot of arduous cell screening and experimentation to be ing the organism, the presence of other compounds, and even performed. However, there is already a vast set of histori- the route of administration. This is a significant problem in cal databases examining toxicity, such as Tox21, that contain the realm of comparative toxicology and in particular the a wealth of important information. In the third article within use of animal models for the screening of compounds. It rep- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied In Vitro Toxicology Mary Ann Liebert

Multiple Approaches to Understanding the Toxic Dose

Applied In Vitro Toxicology , Volume 7 (4): 1 – Dec 1, 2021

Multiple Approaches to Understanding the Toxic Dose

Applied In Vitro Toxicology , Volume 7 (4): 1 – Dec 1, 2021

Abstract

APPLIED IN VITRO TOXICOLOGY EDITORIAL Volume 7, Number 4, 2021 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2021.29025.edi Andrew Gow ne of the principal challenges in all of toxicology sequential metabolisms across a range of cells. Thus the Ois the importance of dose. We are all familiar with the complexity of systems that can be evaluated for toxicity phrase, attributed to Paracelsus, that everything is a poison, in vitro is increased. it is just the dose that counts. However, we have seen that Even with systems such as the Waterfall, where we can dose is not just a linear construct such that a particular streamline complex toxicological assessment, there is still value is toxic. Rather we must consider the situation regard- a lot of arduous cell screening and experimentation to be ing the organism, the presence of other compounds, and even performed. However, there is already a vast set of histori- the route of administration. This is a significant problem in cal databases examining toxicity, such as Tox21, that contain the realm of comparative toxicology and in particular the a wealth of important information. In the third article within use of animal models for the screening of compounds. It rep-

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Publisher
Mary Ann Liebert
Copyright
Copyright 2021, Mary Ann Liebert, Inc., publishers
ISSN
2332-1512
eISSN
2332-1539
DOI
10.1089/aivt.2021.29025.edi
Publisher site
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Abstract

APPLIED IN VITRO TOXICOLOGY EDITORIAL Volume 7, Number 4, 2021 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2021.29025.edi Andrew Gow ne of the principal challenges in all of toxicology sequential metabolisms across a range of cells. Thus the Ois the importance of dose. We are all familiar with the complexity of systems that can be evaluated for toxicity phrase, attributed to Paracelsus, that everything is a poison, in vitro is increased. it is just the dose that counts. However, we have seen that Even with systems such as the Waterfall, where we can dose is not just a linear construct such that a particular streamline complex toxicological assessment, there is still value is toxic. Rather we must consider the situation regard- a lot of arduous cell screening and experimentation to be ing the organism, the presence of other compounds, and even performed. However, there is already a vast set of histori- the route of administration. This is a significant problem in cal databases examining toxicity, such as Tox21, that contain the realm of comparative toxicology and in particular the a wealth of important information. In the third article within use of animal models for the screening of compounds. It rep-

Journal

Applied In Vitro ToxicologyMary Ann Liebert

Published: Dec 1, 2021

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