Abstract

Coenzyme Q10 An Evidence-Based Systematic Review by the Natural Standard Research Collaboration Clinical Bottom Line Side-Effects and Warnings CoQ10 is likely to be safe when up to 3000 mg are taken Brief Background by mouth daily for up to 8 months in healthy people. Nano- • Coenzyme Q10 (CoQ10) is an antioxidant that is made particular CoQ10 is safe at doses of 300 mg daily for up to 3 in the human body. CoQ10 is needed for basic cell func- months. CoQ10 is safe when taken by mouth daily in recom- tion. CoQ10 levels decrease with age and may be low in mended doses in people who are about to have heart surgery, people with cancer, certain genetic disorders, diabetes, or those who have heart disease, gum disease, muscle wast- heart conditions, HIV/AIDS, muscular dystrophies, and ing/weakness, Parkinson’s disease, Alzheimer’s disease, can- Parkinson’s disease. Some prescription drugs may also cer, diabetes, or HIV/AIDS. CoQ10 is also likely to be safe in lower CoQ10 levels. healthy people when taken for exercise performance and in • CoQ10 in the body can be increased by taking CoQ10 children who have chemotherapy side-effects. Idebenone is supplements. There is evidence that idebenone, a human-