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Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances

Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances APPLIED IN VITRO TOXICOLOGY GUEST EDITORIAL Volume 4, Number 2, 2018 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2018.29016.ajc Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances Amy J. Clippinger, PhD the substance’s physiochemical properties, the likely human cientific and ethical drivers have led to significant in- S exposure scenario, and data from in vitro and in silico models terest and investment in developing and using efficient will be critical. Tiered testing can allow for early identifica- human-relevant animal-free testing approaches to assess the toxicity of inhaled substances. Available methods range tion of highly toxic substances in assays that are more high from computational models that predict the deposition pattern throughput and less expensive, followed by more in-depth of a substance in the respiratory tract to physiologically based testing of the remaining substances with more sophisticated pharmacokinetic models that predict the absorption, distribu- in vitro methods. Adverse outcome pathways can serve as a tion, metabolism, and excretion of a chemical to numerous useful framework for designing these intelligent testing strat- in vitro models, including submerged monocultures or cocul- egies, and existing data can be leveraged to gain confidence in ture systems, three-dimensional human http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Applied In Vitro Toxicology Mary Ann Liebert

Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances

Applied In Vitro Toxicology , Volume 4 (2): 1 – Jun 1, 2018

Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances

Applied In Vitro Toxicology , Volume 4 (2): 1 – Jun 1, 2018

Abstract

APPLIED IN VITRO TOXICOLOGY GUEST EDITORIAL Volume 4, Number 2, 2018 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2018.29016.ajc Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances Amy J. Clippinger, PhD the substance’s physiochemical properties, the likely human cientific and ethical drivers have led to significant in- S exposure scenario, and data from in vitro and in silico models terest and investment in developing and using efficient will be critical. Tiered testing can allow for early identifica- human-relevant animal-free testing approaches to assess the toxicity of inhaled substances. Available methods range tion of highly toxic substances in assays that are more high from computational models that predict the deposition pattern throughput and less expensive, followed by more in-depth of a substance in the respiratory tract to physiologically based testing of the remaining substances with more sophisticated pharmacokinetic models that predict the absorption, distribu- in vitro methods. Adverse outcome pathways can serve as a tion, metabolism, and excretion of a chemical to numerous useful framework for designing these intelligent testing strat- in vitro models, including submerged monocultures or cocul- egies, and existing data can be leveraged to gain confidence in ture systems, three-dimensional human

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Publisher
Mary Ann Liebert
Copyright
Copyright 2018, Mary Ann Liebert, Inc.
ISSN
2332-1512
eISSN
2332-1539
DOI
10.1089/aivt.2018.29016.ajc
Publisher site
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Abstract

APPLIED IN VITRO TOXICOLOGY GUEST EDITORIAL Volume 4, Number 2, 2018 ª Mary Ann Liebert, Inc. DOI: 10.1089/aivt.2018.29016.ajc Application of In Silico and In Vitro Approaches to Assess the Toxicity of Inhaled Substances Amy J. Clippinger, PhD the substance’s physiochemical properties, the likely human cientific and ethical drivers have led to significant in- S exposure scenario, and data from in vitro and in silico models terest and investment in developing and using efficient will be critical. Tiered testing can allow for early identifica- human-relevant animal-free testing approaches to assess the toxicity of inhaled substances. Available methods range tion of highly toxic substances in assays that are more high from computational models that predict the deposition pattern throughput and less expensive, followed by more in-depth of a substance in the respiratory tract to physiologically based testing of the remaining substances with more sophisticated pharmacokinetic models that predict the absorption, distribu- in vitro methods. Adverse outcome pathways can serve as a tion, metabolism, and excretion of a chemical to numerous useful framework for designing these intelligent testing strat- in vitro models, including submerged monocultures or cocul- egies, and existing data can be leveraged to gain confidence in ture systems, three-dimensional human

Journal

Applied In Vitro ToxicologyMary Ann Liebert

Published: Jun 1, 2018

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