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Within-Session Reproducibility and Variability of Urethral Resistance and Detrusor Contractility in Pressure-Flow Studies in Men with Lower Urinary Tract Symptoms

Within-Session Reproducibility and Variability of Urethral Resistance and Detrusor Contractility... Aims: To investigate the test-retest reproducibility and variability of urethral resistance and detrusor contractility with-in a session in men with lower urinary tract symptoms, and show their clinical relevance. Materials and Methods: A totals of 263 investigations with 2 pressure-flow studies was included for comparative analysis of test-retest. Obstruction coefficient (OCO), detrusor contraction coefficient (DECO) and Schaefer nomogram were used to detect urethral resistance and detrusor contractility, respectively. Results: Comparing test with retest, OCO had a non-significant sys-tematic change (p > 0.05); DECO had a significant system-atic decrease (p < 0.05). Intraclass correlation coefficients of Q<sub>max</sub>, detrusor pressure at Q<sub>max</sub>, bladder capacity, OCO and DECO were 0.729, 0.927, 0.846, 0.928 and 0.872, respectively (p < 0.001). Using International Continence Society, Abrams-Griffiths and Schaefer nomograms, non-systematic variations in obstructed classification and grade were demonstrated (p > 0.05); whereas, a significantly systematic variation in grade of contractility was found (p < 0.05). Using these nomograms, 9.1–38.0% of investigations changed classification and grade of obstruction, only 9.1–10.3% with clinical relevance. A total of 40.7% of investigations changed the grade of contractility, 20.5% with clinical relevance. Conclusion: We found that pressure-flow parameters had a high reproducibility and reliability from test to retest. The reproducibility and reliability of urethral resistance were better than those of detrusor contractility. The within-patient variations with a non-significant systematic decrease for urethral resistance and with a significant systematic decrease for detrusor contractility were demonstrated. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Urology Karger

Within-Session Reproducibility and Variability of Urethral Resistance and Detrusor Contractility in Pressure-Flow Studies in Men with Lower Urinary Tract Symptoms

Liao, Limin; Schaefer, Werner
Current Urology , Volume 3 (1): 10 – Jan 1, 2009
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References (25)

Publisher
Karger
Copyright
© 2009 S. Karger AG, Basel
ISSN
1661-7649
eISSN
1661-7657
DOI
10.1159/000189677
Publisher site
See Article on Publisher Site

Abstract

Aims: To investigate the test-retest reproducibility and variability of urethral resistance and detrusor contractility with-in a session in men with lower urinary tract symptoms, and show their clinical relevance. Materials and Methods: A totals of 263 investigations with 2 pressure-flow studies was included for comparative analysis of test-retest. Obstruction coefficient (OCO), detrusor contraction coefficient (DECO) and Schaefer nomogram were used to detect urethral resistance and detrusor contractility, respectively. Results: Comparing test with retest, OCO had a non-significant sys-tematic change (p > 0.05); DECO had a significant system-atic decrease (p < 0.05). Intraclass correlation coefficients of Q<sub>max</sub>, detrusor pressure at Q<sub>max</sub>, bladder capacity, OCO and DECO were 0.729, 0.927, 0.846, 0.928 and 0.872, respectively (p < 0.001). Using International Continence Society, Abrams-Griffiths and Schaefer nomograms, non-systematic variations in obstructed classification and grade were demonstrated (p > 0.05); whereas, a significantly systematic variation in grade of contractility was found (p < 0.05). Using these nomograms, 9.1–38.0% of investigations changed classification and grade of obstruction, only 9.1–10.3% with clinical relevance. A total of 40.7% of investigations changed the grade of contractility, 20.5% with clinical relevance. Conclusion: We found that pressure-flow parameters had a high reproducibility and reliability from test to retest. The reproducibility and reliability of urethral resistance were better than those of detrusor contractility. The within-patient variations with a non-significant systematic decrease for urethral resistance and with a significant systematic decrease for detrusor contractility were demonstrated.

Journal

Current Urology – Karger

Published: Jan 1, 2009

Keywords: Pressure-flow study; Reproducibility; Variability; Urethral resistance; Detrusor contractility

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