Access the full text.
Sign up today, get DeepDyve free for 14 days.
S. Donat (2008)
Argument against frozen section analysis of distal ureters in transitional cell bladder cancerNature Clinical Practice Urology, 5
Y. Neuzillet, M. Soulie, S. Larré, M. Rouprêt, G. Defortescu, T. Murez, G. Pignot, A. Descazeaud, J. Patard, P. Bigot, L. Salomon, P. Colin, J. Rigaud, C. Bastide, X. Durand, A. Valéri, F. Kleinclauss, F. Bruyère, C. Pfister (2013)
Positive surgical margins and their locations in specimens are adverse prognosis features after radical cystectomy in non‐metastatic carcinoma invading bladder muscle: results from a nationwide case–control studyBJU International, 111
N. Touma, J. Izawa, M. Abdelhady, M. Moussa, J. Chin (2008)
Ureteral frozen sections at the time of radical cystectomy: reliability and clinical implications.Canadian Urological Association journal = Journal de l'Association des urologues du Canada, 4 1
M. Moschini, A. Gallina, M. Freschi, S. Luzzago, N. Fossati, G. Gandaglia, P. Dell’Oglio, R. Damiano, V. Serretta, A. Salonia, F. Montorsi, A. Briganti, R. Colombo (2016)
Effect on postoperative survival of the status of distal ureteral margin: The necessity to achieve negative margins at the time of radical cystectomy.Urologic oncology, 34 2
M. Schumacher, M. Scholz, E. Weise, A. Fleischmann, G. Thalmann, U. Studer (2006)
Is there an indication for frozen section examination of the ureteral margins during cystectomy for transitional cell carcinoma of the bladder?The Journal of urology, 176 6 Pt 1
S. McCombie, Dickon Hayne (2014)
Current trends in bladder cancer in AustraliaTrends in Urology & Men's Health, 5
E. Compérat, M. Santis, G. Gakis, T. Lebret, A. Sherif (2013)
Guidelines on Muscle-invasive and Metastatic Bladder Cancer
R. Mukha, Santosh Kumar, N. Kekre (2007)
Ureteral frozen section analysis during radical cystectomy: Do margins matter?Indian Journal of Urology : IJU : Journal of the Urological Society of India, 23
T. Sharma, M. Melamed, W. Whitmore (1970)
Carcinoma in‐situ of the ureter in patients with bladder carcinoma treated by cystectomyCancer, 26
Douglas Johnson, K. Wishnow, D. Tenney (1989)
Are frozen-section examinations of ureteral margins required for all patients undergoing radical cystectomy for bladder cancer?Urology, 33 6
H. Kim, K. Moon, C. Jeong, C. Kwak, Hyeon-Hoe Kim, J. Ku (2014)
The clinical significance of intra-operative ureteral frozen section analysis at radical cystectomy for urothelial carcinoma of the bladderWorld Journal of Urology, 33
R. Satkunasivam, B. Hu, Charles Metcalfe, S. Ghodoussipour, M. Aron, Jie Cai, G. Miranda, I. Gill, S. Daneshmand (2016)
Utility and significance of ureteric frozen section analysis during radical cystectomyBJU International, 117
S. Sureka, A. Yadav, S. Arora, R. Kapoor, A. Mandhani (2015)
Is frozen section analysis of the urethra at the time of radical cystectomy and orthotopic neobladder urinary diversion mandatory?Indian Journal of Urology : IJU : Journal of the Urological Society of India, 31
A. Hoang, P. Agarwal, Annerleim Walton-Diaz, C. Wood, A. Metwalli, W. Kassouf, Gordon Brown, Peter Black, D. Urbauer, H. Grossman, C. Dinney, A. Kamat (2014)
Clinical significance of ureteric ‘skip lesions’ at the time of radical cystectomy: the M.D. Anderson experience and literature reviewBJU International, 113
A. Loeser, T. Katzenberger, D. Vergho, A. Kocot, M. Burger, H. Riedmiller (2013)
Frozen Section Analysis of Ureteral Margins in Patients Undergoing Radical Cystectomy for Bladder Cancer: Differential Impact of Carcinoma in situ in the Bladder on Reliability and Impact on Tumour Recurrence in the Upper Urinary TractUrologia Internationalis, 92
N. Ahmadi, W. Delprado, A. Brooks, P. Brenner, G. Coombes, A. Grant, Manish Patel (2015)
Pathological evaluation and quality of surgery in radical cystectomy in New South Wales, AustraliaANZ Journal of Surgery, 85
M. Babjuk, W. Oosterlinck, R. Sylvester, E. Kaasinen, A. Böhle, J. Palou-Redorta, M. Rouprêt (2011)
EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder, the 2011 update.European urology, 59 6
Sang Lee, S. Byun, S. Hong, I. Chang, Yong Kim, M. Gill, S. Song, Kwang Kim (2006)
Significance of Cancer Involvement at the Ureteral Margin Detected on Routine Frozen Section Analysis during Radical CystectomyUrologia Internationalis, 77
Introduction: The objective of this study was to look at the usefulness and cost effectiveness of intraoperative frozen section analysis (FSA) of the ureters at the time of radical cystectomy. Methods: Pathology notes of patients undergoing radical cystectomy for primary bladder cancer between the years 2000-2015 at our institution were reviewed. Results: A total of 196 ureteric specimens from 98 patients were reviewed. Of the 98 patients, 9% (n = 9) had positive ureteric margins, of which all were ≥ T2, with 44% (4 of 9) being T = 4. In all cases of positive FSA, preoperative clinical staging was ≥ T2. In cases where cancer staging was upgraded post-cystectomy, there were no cases of positive FSA. After adjusting for tumor stage in ≥ T2a, using Cox regression analysis, positive frozen section was associated with a 4.2 fold increase in overall mortality (95%CI 1.3-13.8; p = 0.02). Cost associated with FSA was AU$1,351.90 to obtain 1 positive result. Conclusion: Patients with positive ureteric FSA are at higher risk of mortality post cystectomy, despite excision to negative tissue. However, FSA of the distal ureters at cystectomy were unlikely to be positive unless the bladder cancer stage was ≥ T2. Hence, routine ureteric FSA may not be necessary in patients undergoing cystectomy for non-muscle invasive bladder tumors.
Current Urology – Karger
Published: Jan 1, 2019
Keywords: Frozen section; Ureter; Cystectomy; Mortality; Cost effectiveness
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.