Access the full text.
Sign up today, get DeepDyve free for 14 days.
A. Murphy, A. Manoel, R. Macdonald, A. Baker, Ting-Yim Lee, T. Marotta, W. Montanera, R. Aviv, A. Bharatha (2017)
Changes in Cerebral Perfusion with Induced Hypertension in Aneurysmal Subarachnoid Hemorrhage: A Pilot and Feasibility StudyNeurocritical Care, 27
Charles Taylor, M. Draney (2004)
EXPERIMENTAL AND COMPUTATIONAL METHODS IN CARDIOVASCULAR FLUID MECHANICSAnnual Review of Fluid Mechanics, 36
N. Shimamura, Masato Naraoka, Naoya Matsuda, Kiyohide Kakuta, H. Ohkuma (2014)
Prophylactic Intra-Arterial Injection of Vasodilator for Asymptomatic Vasospasm Converts the Patient to Symptomatic Vasospasm due to Severe Microcirculatory ImbalanceBioMed Research International, 2014
Pablo Blanco, Lucas Müller, Sansuke Watanabe, R. Feijóo (2016)
Computational modeling of blood flow steal phenomena caused by subclavian stenoses.Journal of biomechanics, 49 9
L. Müller, P. Blanco, Sansuke Watanabe, R. Feijóo (2016)
A high‐order local time stepping finite volume solver for one‐dimensional blood flow simulations: application to the ADAN modelInternational Journal for Numerical Methods in Biomedical Engineering, 32
D. Young, F. Tsai (1973)
Flow characteristics in models of arterial stenoses. II. Unsteady flow.Journal of biomechanics, 6 5
Janice Miller, R. Dacey, M. Diringer (1995)
Safety of hypertensive hypervolemic therapy with phenylephrine in the treatment of delayed ischemic deficits after subarachnoid hemorrhage.Stroke, 26 12
K. Matthys, J. Alastruey, J. Peiró, A. Khir, P. Segers, P. Verdonck, K. Parker, S. Sherwin (2007)
Pulse wave propagation in a model human arterial network: assessment of 1-D numerical simulations against in vitro measurements.Journal of biomechanics, 40 15
T. Iberti (1983)
Treatment of ischemic deficits from vasospasm with intravascular volume expansion and induced arterial hypertension.Neurosurgery, 12 6
J. Sen, A. Belli, H. Albon, L. Morgan, A. Petzold, N. Kitchen (2003)
Triple-H therapy in the management of aneurysmal subarachnoid haemorrhageThe Lancet Neurology, 2
I. Awad, L. Carter, R. Spetzler, Marjorie Medina, Fred Williams, Philip Carter (1987)
Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension.Stroke, 18 2
J. Frontera, A. Fernández, J. Schmidt, J. Claassen, K. Wartenberg, N. Badjatia, E. Connolly, S. Mayer (2010)
Clinical Response to Hypertensive Hypervolemic Therapy and Outcome After Subarachnoid HemorrhageNeurosurgery, 66
J. Dankbaar, A. Slooter, G. Rinkel, I. Schaaf (2010)
Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic reviewCritical Care, 14
P. Blanco, Sansuke Watanabe, E. Dari, M. Passos, R. Feijóo (2014)
Blood flow distribution in an anatomically detailed arterial network model: criteria and algorithmsBiomechanics and Modeling in Mechanobiology, 13
H. Kwon, Jeongwook Lim, H. Koh, Bumsoo Park, Seung-Won Choi, Seon-Hwan Kim, J. Youm, Shi-Hun Song (2018)
Stent-Retriever Angioplasty for Recurrent Post-Subarachnoid Hemorrhagic Vasospasm – A Single Center Experience with Long-Term Follow-UpClinical Neuroradiology
D. Young, F. Tsai (1973)
Flow characteristics in models of arterial stenoses. I. Steady flow.Journal of biomechanics, 6 4
A. Raabe, J. Beck, M. Keller, H. Vatter, M. Zimmermann, V. Seifert (2005)
Relative importance of hypertension compared with hypervolemia for increasing cerebral oxygenation in patients with cerebral vasospasm after subarachnoid hemorrhage.Journal of neurosurgery, 103 6
D. Swift, R. Solomon (1992)
Unruptured aneurysms and postoperative volume expansion.Journal of neurosurgery, 77 6
J. Muizelaar, D. Becker (1986)
Induced hypertension for the treatment of cerebral ischemia after subarachnoid hemorrhage. Direct effect on cerebral blood flow.Surgical neurology, 25 4
The Effects of Cerebral Vasospasm on Cerebral Blood Flow and the Effects of Induced Hypertension : A Mathematical Modelling Study
P. Reymond, Y. Bohraus, F. Perren, F. Lazeyras, N. Stergiopulos (2011)
Validation of a patient-specific one-dimensional model of the systemic arterial tree.American journal of physiology. Heart and circulatory physiology, 301 3
J. Alastruey, A. Khir, K. Matthys, P. Segers, S. Sherwin, P. Verdonck, K. Parker, J. Peiró (2011)
Pulse wave propagation in a model human arterial network: Assessment of 1-D visco-elastic simulations against in vitro measurementsJournal of Biomechanics, 44
P. Blanco, Sansuke Watanabe, M. Passos, P. Lemos, R. Feijóo (2015)
An Anatomically Detailed Arterial Network Model for One-Dimensional Computational HemodynamicsIEEE Transactions on Biomedical Engineering, 62
H. Touho, Jun Karasawa, Hideyuki Ohnishi, H. Shishido, Keisuke Yamada, K. Shibamoto (1992)
Evaluation of therapeutically induced hypertension in patients with delayed cerebral vasospasm by xenon-enhanced computed tomography.Neurologia medico-chirurgica, 32 9
M. Levitt, R. Morton, D. Haynor, W. Cohen, B. Ghodke, D. Hallam, L. Kim, Kathleen Fink (2014)
Angiographic Perfusion Imaging: Real‐Time Assessment of Endovascular Treatment for Cerebral VasospasmJournal of Neuroimaging, 24
M. Olufsen, C. Peskin, W. Kim, E. Pedersen, A. Nadim, J. Larsen (2000)
Numerical Simulation and Experimental Validation of Blood Flow in Arteries with Structured-Tree Outflow ConditionsAnnals of Biomedical Engineering, 28
Bhaskar Roy, L. McCullough, R. Dhar, J. Grady, Yu-bo Wang, Robert Brown (2017)
Comparison of Initial Vasopressors Used for Delayed Cerebral Ischemia after Aneurysmal Subarachnoid HemorrhageCerebrovascular Diseases, 43
H. Engquist, E. Rostami, E. Ronne-Engström, P. Nilsson, A. Lewén, P. Enblad (2017)
Effect of HHH-Therapy on Regional CBF after Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CTNeurocritical Care, 28
L. Müller, E. Toro (2014)
A global multiscale mathematical model for the human circulation with emphasis on the venous systemInternational Journal for Numerical Methods in Biomedical Engineering, 30
N. Stergiopulos, D. Young, T. Rogge (1992)
Computer simulation of arterial flow with applications to arterial and aortic stenoses.Journal of biomechanics, 25 12
R. Macdonald (2014)
Delayed neurological deterioration after subarachnoid haemorrhageNature Reviews Neurology, 10
F. Vosse, N. Stergiopulos (2011)
Pulse Wave Propagation in the Arterial TreeAnnual Review of Fluid Mechanics, 43
E. Kosnik, W. Hunt (1976)
Postoperative hypertension in the management of patients with intracranial arterial aneurysms.Journal of neurosurgery, 45 2
C. Gathier, J. Dankbaar, M. Jagt, B. Verweij, A. Oldenbeuving, G. Rinkel, W. Bergh, A. Slooter (2015)
Effects of Induced Hypertension on Cerebral Perfusion in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical TrialStroke, 46
P. Bhogal, D. Paraskevopoulos, H. Makalanda (2017)
The use of a stent-retriever to cause mechanical dilatation of a vasospasm secondary to iatrogenic subarachnoid haemorrhageInterventional Neuroradiology, 23
P. Bhogal, Y. Loh, P. Brouwer, T. Andersson, M. Söderman (2016)
Treatment of cerebral vasospasm with self-expandable retrievable stents: proof of conceptJournal of NeuroInterventional Surgery, 9
C. Gathier, W. Bergh, M. Jagt, B. Verweij, J. Dankbaar, M. Müller, A. Oldenbeuving, G. Rinkel, A. Slooter, A. Algra, J. Kesecioglu, I. Schaaf, R. Dammers, D. Dippel, C. Dirven, F. Kooten, A. Lugt, B. Coert, J. Horn, W. Vandertop, G. Beute, B. Pol, G. Roks, W. Rooij, M. Sluzewski (2018)
Induced Hypertension for Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Randomized Clinical TrialStroke, 49
A. Qureshi, J. Suarez, A. Bhardwaj, Abutaher Yahia, R. Tamargo, J. Ulatowski (2000)
Early predictors of outcome in patients receiving hypervolemic and hypertensive therapy for symptomatic vasospasm after subarachnoid hemorrhageCritical Care Medicine, 28
H. Otsubo, T. Takemae, Toshiki Inoue, S. Kobayashi, K. Sugita (2005)
Normovolaemic induced hypertension therapy for cerebral vasospasm after subarachnoid haemorrhageActa Neurochirurgica, 103
Background: Induced hypertension has been used to promote cerebral blood flow under vasospastic conditions although there is no randomised clinical trial to support its use. We sought to mathematically model the effects of vasospasm on the cerebral blood flow and the effects of induced hypertension. Methods: The Anatomically Detailed Arterial Network (ADAN) model is employed as the anatomical substrate in which the cerebral blood flow is simulated as part of the simulation of the whole body arterial circulation. The pressure drop across the spastic vessel is modelled by inserting a specific constriction model within the corresponding vessel in the ADAN model. We altered the degree of vasospasm, the length of the vasospastic segment, the location of the vasospasm, the pressure (baseline mean arterial pressure [MAP] 90 mm Hg, hypertension MAP 120 mm Hg, hypotension), and the presence of collateral supply. Results: Larger decreases in cerebral flow were seen for diffuse spasm and more severe vasospasm. The presence of collateral supply could maintain cerebral blood flow, but only if the vasospasm did not occur distal to the collateral. Induced hypertension caused an increase in blood flow in all scenarios, but did not normalise blood flow even in the presence of moderate vasospasm (30%). Hypertension in the presence of a complete circle of Willis had a marginally greater effect on the blood flow, but did not normalise flow. Conclusion: Under vasospastic condition, cerebral blood flow varies considerably. Hypertension can raise the blood flow, but it is unable to restore cerebral blood flow to baseline.
Interventional Neurology – Karger
Published: Jan 1, 2020
Keywords: Cerebral vasospasm; Modelling; Induced hypertension; Subarachnoid haemorrhage
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.