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Predictors of Cancer-Specific Survival following Radical Cystectomy in Patients with Node-Positive Bladder Cancer

Predictors of Cancer-Specific Survival following Radical Cystectomy in Patients with... Background: This study retrospectively assessed prognostic outcomes following radical cystectomy in patients with node-positive bladder cancer. Patients and Methods: This study included 82 patients who underwent radical cystectomy and pelvic lymphadenectomy for bladder cancer without any neo-adjuvant therapies and were subsequently diagnosed as having pelvic lymph node metastases. The medical records of these patients were retrospectively reviewed with emphasis on their oncological outcomes. Results: The mean number of resected lymph nodes, positive lymph nodes and degree of positive lymph node density were 14.4, 3.1 and 25.3%, respectively, and 27 patients (33.0%) had positive lymph nodes bilaterally. During the observation period of this study (mean 33.6 months), 55 patients (67.1%) died of disease progression, and the 1-, 3- and 5-year cancer-specific survival rates of the 82 patients were 73.2, 31.7 and 21.2%, respectively. Univariate analysis identified the number of positive lymph nodes, positive lymph node density, laterality of positive lymph nodes and adjuvant chemotherapy as significant predictors of cancer-specific survival; however, only positive lymph node density appeared to be independently associated with cancer-specific survival on multivariate analysis. Conclusions: Positive lymph node density represents a significant prognostic variable for cancer-specific survival in patients with node-positive bladder cancer following radical cystectomy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Urology Karger

Predictors of Cancer-Specific Survival following Radical Cystectomy in Patients with Node-Positive Bladder Cancer

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Publisher
Karger
Copyright
© 2010 S. Karger AG, Basel
ISSN
1661-7649
eISSN
1661-7657
DOI
10.1159/000323243
Publisher site
See Article on Publisher Site

Abstract

Background: This study retrospectively assessed prognostic outcomes following radical cystectomy in patients with node-positive bladder cancer. Patients and Methods: This study included 82 patients who underwent radical cystectomy and pelvic lymphadenectomy for bladder cancer without any neo-adjuvant therapies and were subsequently diagnosed as having pelvic lymph node metastases. The medical records of these patients were retrospectively reviewed with emphasis on their oncological outcomes. Results: The mean number of resected lymph nodes, positive lymph nodes and degree of positive lymph node density were 14.4, 3.1 and 25.3%, respectively, and 27 patients (33.0%) had positive lymph nodes bilaterally. During the observation period of this study (mean 33.6 months), 55 patients (67.1%) died of disease progression, and the 1-, 3- and 5-year cancer-specific survival rates of the 82 patients were 73.2, 31.7 and 21.2%, respectively. Univariate analysis identified the number of positive lymph nodes, positive lymph node density, laterality of positive lymph nodes and adjuvant chemotherapy as significant predictors of cancer-specific survival; however, only positive lymph node density appeared to be independently associated with cancer-specific survival on multivariate analysis. Conclusions: Positive lymph node density represents a significant prognostic variable for cancer-specific survival in patients with node-positive bladder cancer following radical cystectomy.

Journal

Current UrologyKarger

Published: Jan 1, 2010

Keywords: Bladder cancer; Radical cystectomy; Lymph node metastases

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