Access the full text.
Sign up today, get DeepDyve free for 14 days.
Elisabct Granstam, Lin Wang, Anders Bill (1992)
Ocular effects of endothelin-1 in the cat.Current eye research, 11 4
Kazuhiro Takahashi, M. Ghatei, H. Lam, D. O'halloran, S. Bloom (1990)
Elevated plasma endothelin in patients with diabetes mellitusDiabetologia, 33
J. Grunwald, A. Maguire, J. Dupont (1996)
Retinal hemodynamics in retinitis pigmentosa.American journal of ophthalmology, 122 4
S. Dallinger, G. Dorner, Roland Wenzel, U. Graselli, O. Findl, Hans-Georg Eichler, Michael Wolzt, L. Schmetterer (2000)
Endothelin-1 contributes to hyperoxia-induced vasoconstriction in the human retina.Investigative ophthalmology & visual science, 41 3
A. Lerman, B. Edwards, J. Hallett, D. Heublein, S. Sandberg, J. Burnett (1991)
Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis.The New England journal of medicine, 325 14
H. Ishikawa, T. Yoshitomi, Y. Harada, M. Katori, S. Ishikawa (1993)
The presence of two sites of action of endothelins in the isolated rabbit iris sphincter and dilator muscles.Current eye research, 12 12
Pearlman Jt (1979)
Mathematical models of retinitis pigmentosa: a study of the rate of progress in the different genetic forms.Transactions of the American Ophthalmological Society, 77
M. MacCumber, H. Jampel, S. Snyder (1991)
Ocular effects of the endothelins. Abundant peptides in the eye.Archives of ophthalmology, 109 5
M. Cellini, R. Lodi, G. Possati, M. Sbrocca, D. Pelle, N. Giubilei (1997)
[Color Doppler ultrasonography in retinitis pigmentosa. Preliminary study].Journal francais d'ophtalmologie, 20 9
(1997)
Echo-Doppler couleur dans la rétinopathie pigmentaire
(1932)
Zur Histologie der Pigmentdegene - ration der Netzhaut
Retinitis Pigmentosa, D. Lucas, Wernher Group (1956)
RETINITIS PIGMENTOSA PATHOLOGICAL FINDINGS IN TWO CASES*British Journal of Ophthalmology, 40
M. Kohno, K. Yasunari, K. Murakawa, K. Yokokawa, T. Horio, T. Fukui, T. Takeda (1990)
Plasma immunoreactive endothelin in essential hypertension.The American journal of medicine, 88 6
M. Langham, T. Kramer (1990)
Decreased choroidal blood flow associated with retinitis pigmentosaEye, 4
Ronald Carr, Kenneth Noble (1981)
9. Retinitis PigmentosaOphthalmology, 88
J. Wolter (1957)
Retinitis pigmentosa; a histopathologic study with a new technique.A.M.A. archives of ophthalmology, 57 4
Jordan Ueberroth (1941)
RETINITIS PIGMENTOSAThe Lancet, 328
T. Masaki, S. Kimura, M. Yanagisawa, K. Goto (1991)
Molecular and Cellular Mechanism of Endothelin Regulation: Implications for Vascular FunctionCirculation, 84
C. Pournaras, Charles Riva, Charles Riva, M. Tsacopoulos, K. Strommer (1989)
Diffusion of O2 in the retina of anesthetized miniature pigs in normoxia and hyperoxia.Experimental eye research, 49 3
M. Simonson, M. Dunn (1990)
Cellular signaling by peptides of the endothelin gene familyThe FASEB Journal, 4
Zoned Li, D. Possin, A. Milam (1995)
Histopathology of bone spicule pigmentation in retinitis pigmentosa.Ophthalmology, 102 5
M. Yanagisawa, H. Kurihara, S. Kimura, Y. Tomobe, Mieko Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, T. Masaki (1988)
A novel potent vasoconstrictor peptide produced by vascular endothelial cellsNature, 332
R. Szamier, E. Berson (1977)
Retinal ultrastructure in advanced retinitis pigmentosa.Investigative ophthalmology & visual science, 16 10
P. Chollet, F. Malecaze, L. Gouzi, J. Arné, J. Plouet (1993)
Endothelin 1 is a growth factor for corneal endothelium.Experimental eye research, 57 5
S. Wolf1, H. Pöstgens1, B. Bertram1, K. Schulte1, C. Teping2, M. Reim1 (1991)
Hämodynamische Befunde bei Patienten mit Retinitis pigmentosaKlinische Monatsblätter für Augenheilkunde, 199
John Stone, W. Barlow, M. Humayun, E. Juan, A. Milam (1992)
Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa.Archives of ophthalmology, 110 11
T. Miyauchi, M. Yanagisawa, T. Tomizawa, Y. Sugishita, N. Suzuki, M. Fujino, R. Ajisaka, K. Goto, T. Masaki (1989)
INCREASED PLASMA CONCENTRATIONS OF ENDOTHELIN-1 AND BIG ENDOTHELIN-1 IN ACUTE MYOCARDIAL INFARCTIONThe Lancet, 334
C. Ulrich, W. Ulrich, K. Vehlow, S. Vehlow (1991)
[Hemodynamic aspects of retinitis pigmentosa].Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 88 6
S. Wolf, H. Pöstgens, B. Bertram, K. Schulte, C. Teping, M. Reim (1991)
[Hemodynamic findings in patients with retinitis pigmentosa].Klinische Monatsblatter fur Augenheilkunde, 199 5
Retinitis pigmentosa (RP) is an inherited retinal disorder clinically characterized by a pale, waxy optic nerve head, attenuated retinal blood vessels and bone spicule pigment in the retina. Hemodynamic studies have demonstrated that RP is associated with a reduction in the retinal and choroidal blood flow. Retinal hemodynamic impairment is also present in the early stages of RP and various hypotheses have been advanced as to its cause. The authors studied 20 patients, 12 males and 8 females, aged between 26 and 42 years (mean 34.6 years) affected by simplex RP. The twenty patients were divided in two groups according to the degree of sight impairment: group A consisted of 10 patients with a visual acuity of 0.3 ± 0.1, visual field mean defect 18.988 ± 3.419 dB and b-wave electroretinogram amplitude of 13.14 ± 0.308 µV. Group B consisted of 10 patients with a visual acuity of 0.8 ± 0.2, visual field MD 10.523 ± 3.582 dB and b-wave electroretinogram amplitude of 26.000 ± 0.757 µV. An increase in plasma levels of endothelin-1 (ET-1) was found as compared with healthy controls: 1.910 ± 0.617 pg/ml vs. 1.180 ± 0.210 pg/ml (p < 0.021), but there was no statistical difference between group A and B (p < 0.163). It is thought that an increase in ET-1 and retinal oxygen levels in RP could lead to vasoconstriction and a decrease in the retinal blood flow worsening the abiotrophic process.
Ophthalmologica – Karger
Published: Aug 1, 2002
Keywords: Endothelin-1; Ocular blood flow; Retinitis pigmentosa
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.