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Physical Activity Decreases Kidney Cancer Mortality

Physical Activity Decreases Kidney Cancer Mortality Background: To investigate associations of kidney cancer mortality with modifiable risk factors of obesity, physical activity, and smoking. Methods: We evaluate baseline data from US National Health Information Survey from 1998 through 2004 linked to mortality data reporting deaths through 2006. The primary outcome variable was kidney cancer-specific mortality and primary exposure variables were self-reported physical activity and body mass index (BMI). We utilized multivariable adjusted Cox proportional hazards regression models, with delayed entry to account for age at survey interview. Results: Among 222,163 individuals with complete follow-up data we identified 71 kidney cancer-specific deaths. In multivariate analyses, individuals who reported “any physical activity” were 50% less likely [adjusted hazard ratio (adjusted HR) 0.50, 95% CI 0.27-0.93, p = 0.028] to die of kidney cancer than non-exercisers, while obese individuals (BMI ≥ 30 kg/m<sup>2</sup>) were nearly 3 times more likely (adjusted HR 2.84, 95% CI 1.30-6.23, p = 0.009) compared to those of normal weight (BMI < 25 kg/m<sup>2</sup>). Compared to never smokers, former smokers were twice as likely to die of kidney cancer (adjusted HR 2.00, 95% CI 1.05-3.80, p = 0.034). Conclusion: Physical activity decreases and obesity increases the risk of kidney cancer mortality. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Urology Karger

Physical Activity Decreases Kidney Cancer Mortality

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Publisher
Karger
Copyright
© 2016 S. Karger AG, Basel
ISSN
1661-7649
eISSN
1661-7657
DOI
10.1159/000447180
Publisher site
See Article on Publisher Site

Abstract

Background: To investigate associations of kidney cancer mortality with modifiable risk factors of obesity, physical activity, and smoking. Methods: We evaluate baseline data from US National Health Information Survey from 1998 through 2004 linked to mortality data reporting deaths through 2006. The primary outcome variable was kidney cancer-specific mortality and primary exposure variables were self-reported physical activity and body mass index (BMI). We utilized multivariable adjusted Cox proportional hazards regression models, with delayed entry to account for age at survey interview. Results: Among 222,163 individuals with complete follow-up data we identified 71 kidney cancer-specific deaths. In multivariate analyses, individuals who reported “any physical activity” were 50% less likely [adjusted hazard ratio (adjusted HR) 0.50, 95% CI 0.27-0.93, p = 0.028] to die of kidney cancer than non-exercisers, while obese individuals (BMI ≥ 30 kg/m<sup>2</sup>) were nearly 3 times more likely (adjusted HR 2.84, 95% CI 1.30-6.23, p = 0.009) compared to those of normal weight (BMI < 25 kg/m<sup>2</sup>). Compared to never smokers, former smokers were twice as likely to die of kidney cancer (adjusted HR 2.00, 95% CI 1.05-3.80, p = 0.034). Conclusion: Physical activity decreases and obesity increases the risk of kidney cancer mortality.

Journal

Current UrologyKarger

Published: Jan 1, 2017

Keywords: Renal cancer; Mortality; Modifable risk; Exercise; Physical activity; Obesity; Smoking

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