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0.5% timolol without preservative reduces corneal sensitivity for a shorter period of time than timolol with preservative. The subjective tolerance of unpreserved timolol is much better than that of preserved timolol. The latter and 0.5% levobunolol are significantly more poorly tolerated than buffer solution. The smaller the anesthetic side effects, the better the subjective tolerance of the Β-blockers.
Ophthalmologica – Karger
Published: Jan 1, 2010
Keywords: Timolol; Preservative-free preparation; Surface-anesthetic effect; Compatibility; Levobunolol; Placebo; Comparative study
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