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New Insights into the Diagnosis and Treatment of Vitreoretinal Diseases

New Insights into the Diagnosis and Treatment of Vitreoretinal Diseases Ophthalmologica at a Glance Ophthalmologica 2007;221:215 DOI: 10.1159/000103215 New Insights into the Diagnosis and Treatment of Vitreoretinal Diseases ware, the adjusted technique allows the operator to select the inter- Ocular Photodynamic Therapy – face landmarks. The authors found that the repeatability of adjusted Standard Applications and New Indications retinal thickness measurements is higher than that of automated Stefan Mennel, Irene Barbazetto, Carsten H. Meyer, Silvia Peter, ones. Michael Stur In the future, new OCT machines with higher resolution and a combination with fundus imaging and/or angiography will increase Ophthalmologica 2007; 221:216–226 the significance of this diagnostic tool. The introduction of ocular photodynamic therapy (PDT) was a milestone in the development of therapeutic regimens to treat neovas- Diurnal Variation of the Incidence of Symptomatic cular age-related macular degeneration (AMD). By the end of the Branch Retinal Vein Occlusion 1990s, with the introduction of PDT, we had great expectations to sta- bilize or even increase visual acuity of neovascular AMD patients. Jaeryung Oh, In Kyung Oh, Kuhl Huh Unfortunately, visual acuity decreased in most cases although several Ophthalmologica 2007; 221:251–254 treatment sessions of PDT were performed. Today, with the introduc- tion of anti-VEGF therapy, the role of PDT will certainly change. For The pathophysiology of branch retinal vein occlusion (BRVO) is almost all cases, PDT is not the fist choice of treatment anymore. not fully investigated and several factors may be involved. The onset Additionally to neovascular AMD, PDT has been performed in of first symptoms of BRVO has been evaluated by Jaeyung Oh and several other ocular pathologies. A literature review concerning the coworkers. The analysis of 72 consecutive patients demonstrated a effect and treatment parameters of PDT for different ocular diseases distribution with a highly significant peak in the period from 6 a.m. is missing in the world literature. Stefan Mennel and coworkers re- to noon. Circadian variation has been demonstrated in several types viewed the literature. In part 1, they present the standard application of ocular and systemic vascular diseases. The authors hypothesize of PDT as well as treatment of choroidal neovascularization due to that probably, similar to nonarteritic anterior ischemic optic neu- other pathologies. In part 2, published in the next issue, the authors ropathy, nocturnal arterial hypotension combined with a rise of in- describe PDT in the treatment of ocular tumors and other applica- traocular pressure during sleep may be a risk factor for BRVO by tions in ophthalmology and discuss current and future applications. reducing ocular perfusion pressure. Intraobserver Repeatability of Automated Epidermal Growth Factor Receptor in Cultured versus Adjusted Optical Coherence Tomography Human Retinal Pigment Epithelial Cells Measurements in Patients with Neovascular Feng Yan, Yan-nian Hui, Yang-jun Li, Chang-mei Guo, Hao Meng Age-Related Macular Degeneration Ophthalmologica 2007; 221:244–250 Sinan Tatlipinar, Syed Mahmood Shah, Peter A. Campochiaro, Quan Dong Nguyen Proliferative vitreoretinopathy (PVR) is the major cause of failure Ophthalmologica 2007; 221:227–232 following retinal detachment surgery. Although retinal pigment epi- thelium (RPE) has been advocated to be causative, several cell types, Since the introduction of anti-VEGF therapy to treat age-related growth factors and immunomodulation are known today to play a key macular degeneration, the importance of optical coherence tomogra- role in the induction and progression of PVR. Feng Yan and coworkers phy (OCT) has even increased. Macular thickness has been shown to investigated the activation and role of the epidermal growth factor re- correlate with visual acuity, disease activity and represents an effec- ceptor signal transduction pathway in the proliferation of human RPE tive diagnostic tool to evaluate intravitreal anti-VEGF therapy. The cells. They observed that epidermal growth factor induced the mito- gold standard of f luorescein angiography is essential today for preop- gen-activated protein kinase signal transduction pathway in human erative evaluation; nevertheless, the noninvasive examination by RPE cells in a concentration-dependent manner in vitro. This may play OCT seems sufficient enough to evaluate treatment efficacy and de- a key role in the activation of human RPE cell proliferation and migra- cide whether retreatment is necessary. tion. Future studies are necessary to assess the clinical relevance of Tatlipinar and coworker assessed the intraobserver repeatability their findings. of automated versus adjusted OCT. Whereas the automated OCT de- Prof. Dr. Peter Kroll, Marburg tects the inner and outer high-ref lectivity layer by an included soft- © 2007 S. Karger AG, Basel 0030–3755/07/2214–0215$23.50/0 Fax +41 61 306 12 34 E-Mail karger@karger.ch Accessible online at: www.karger.com www.karger.com/oph http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ophthalmologica Karger

New Insights into the Diagnosis and Treatment of Vitreoretinal Diseases

Ophthalmologica , Volume 221 (4): 1 – Jun 1, 2007

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Publisher
Karger
Copyright
© 2007 S. Karger AG, Basel
ISSN
0030-3755
eISSN
1423-0267
DOI
10.1159/000103215
Publisher site
See Article on Publisher Site

Abstract

Ophthalmologica at a Glance Ophthalmologica 2007;221:215 DOI: 10.1159/000103215 New Insights into the Diagnosis and Treatment of Vitreoretinal Diseases ware, the adjusted technique allows the operator to select the inter- Ocular Photodynamic Therapy – face landmarks. The authors found that the repeatability of adjusted Standard Applications and New Indications retinal thickness measurements is higher than that of automated Stefan Mennel, Irene Barbazetto, Carsten H. Meyer, Silvia Peter, ones. Michael Stur In the future, new OCT machines with higher resolution and a combination with fundus imaging and/or angiography will increase Ophthalmologica 2007; 221:216–226 the significance of this diagnostic tool. The introduction of ocular photodynamic therapy (PDT) was a milestone in the development of therapeutic regimens to treat neovas- Diurnal Variation of the Incidence of Symptomatic cular age-related macular degeneration (AMD). By the end of the Branch Retinal Vein Occlusion 1990s, with the introduction of PDT, we had great expectations to sta- bilize or even increase visual acuity of neovascular AMD patients. Jaeryung Oh, In Kyung Oh, Kuhl Huh Unfortunately, visual acuity decreased in most cases although several Ophthalmologica 2007; 221:251–254 treatment sessions of PDT were performed. Today, with the introduc- tion of anti-VEGF therapy, the role of PDT will certainly change. For The pathophysiology of branch retinal vein occlusion (BRVO) is almost all cases, PDT is not the fist choice of treatment anymore. not fully investigated and several factors may be involved. The onset Additionally to neovascular AMD, PDT has been performed in of first symptoms of BRVO has been evaluated by Jaeyung Oh and several other ocular pathologies. A literature review concerning the coworkers. The analysis of 72 consecutive patients demonstrated a effect and treatment parameters of PDT for different ocular diseases distribution with a highly significant peak in the period from 6 a.m. is missing in the world literature. Stefan Mennel and coworkers re- to noon. Circadian variation has been demonstrated in several types viewed the literature. In part 1, they present the standard application of ocular and systemic vascular diseases. The authors hypothesize of PDT as well as treatment of choroidal neovascularization due to that probably, similar to nonarteritic anterior ischemic optic neu- other pathologies. In part 2, published in the next issue, the authors ropathy, nocturnal arterial hypotension combined with a rise of in- describe PDT in the treatment of ocular tumors and other applica- traocular pressure during sleep may be a risk factor for BRVO by tions in ophthalmology and discuss current and future applications. reducing ocular perfusion pressure. Intraobserver Repeatability of Automated Epidermal Growth Factor Receptor in Cultured versus Adjusted Optical Coherence Tomography Human Retinal Pigment Epithelial Cells Measurements in Patients with Neovascular Feng Yan, Yan-nian Hui, Yang-jun Li, Chang-mei Guo, Hao Meng Age-Related Macular Degeneration Ophthalmologica 2007; 221:244–250 Sinan Tatlipinar, Syed Mahmood Shah, Peter A. Campochiaro, Quan Dong Nguyen Proliferative vitreoretinopathy (PVR) is the major cause of failure Ophthalmologica 2007; 221:227–232 following retinal detachment surgery. Although retinal pigment epi- thelium (RPE) has been advocated to be causative, several cell types, Since the introduction of anti-VEGF therapy to treat age-related growth factors and immunomodulation are known today to play a key macular degeneration, the importance of optical coherence tomogra- role in the induction and progression of PVR. Feng Yan and coworkers phy (OCT) has even increased. Macular thickness has been shown to investigated the activation and role of the epidermal growth factor re- correlate with visual acuity, disease activity and represents an effec- ceptor signal transduction pathway in the proliferation of human RPE tive diagnostic tool to evaluate intravitreal anti-VEGF therapy. The cells. They observed that epidermal growth factor induced the mito- gold standard of f luorescein angiography is essential today for preop- gen-activated protein kinase signal transduction pathway in human erative evaluation; nevertheless, the noninvasive examination by RPE cells in a concentration-dependent manner in vitro. This may play OCT seems sufficient enough to evaluate treatment efficacy and de- a key role in the activation of human RPE cell proliferation and migra- cide whether retreatment is necessary. tion. Future studies are necessary to assess the clinical relevance of Tatlipinar and coworker assessed the intraobserver repeatability their findings. of automated versus adjusted OCT. Whereas the automated OCT de- Prof. Dr. Peter Kroll, Marburg tects the inner and outer high-ref lectivity layer by an included soft- © 2007 S. Karger AG, Basel 0030–3755/07/2214–0215$23.50/0 Fax +41 61 306 12 34 E-Mail karger@karger.ch Accessible online at: www.karger.com www.karger.com/oph

Journal

OphthalmologicaKarger

Published: Jun 1, 2007

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