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Leber’s Hereditary Optic Neuropathy Mutations in Korean Patients with Multiple Sclerosis

Leber’s Hereditary Optic Neuropathy Mutations in Korean Patients with Multiple Sclerosis Several different mitochondrial DNA (mtDNA) sites for mutations of Leber’s hereditary optic neuropathy (LHON) have been reported to be present in patients with multiple sclerosis (MS). To further study this association of LHON and MS in the Korean population, we tested 20 MS patients for the presence of mtDNA mutations at nucleotide (nt) 11778 in all 20 patients, and at nt 14484, nt 3460 and nt 15257 in 15, 12 and 12 patients, respectively. However, none of the MS patients exhibited any pathogenic LHON mtDNA mutations. In conclusion, we found no evidence for any association between MS and the LHON mutation in the Korean population. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ophthalmologica Karger

Leber’s Hereditary Optic Neuropathy Mutations in Korean Patients with Multiple Sclerosis

Ophthalmologica , Volume 215 (6): 3 – Dec 1, 2001

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References (18)

Publisher
Karger
Copyright
© 2001 S. Karger AG, Basel
ISSN
0030-3755
eISSN
1423-0267
DOI
10.1159/000050896
Publisher site
See Article on Publisher Site

Abstract

Several different mitochondrial DNA (mtDNA) sites for mutations of Leber’s hereditary optic neuropathy (LHON) have been reported to be present in patients with multiple sclerosis (MS). To further study this association of LHON and MS in the Korean population, we tested 20 MS patients for the presence of mtDNA mutations at nucleotide (nt) 11778 in all 20 patients, and at nt 14484, nt 3460 and nt 15257 in 15, 12 and 12 patients, respectively. However, none of the MS patients exhibited any pathogenic LHON mtDNA mutations. In conclusion, we found no evidence for any association between MS and the LHON mutation in the Korean population.

Journal

OphthalmologicaKarger

Published: Dec 1, 2001

Keywords: Leber’s hereditary optic neuropathy; Mitochondrial DNA mutation; Multiple sclerosis

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