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M. Avgeris, K. Stravodimos, A. Scorilas (2011)
Kallikrein‐related peptidase 4 gene (KLK4) in prostate tumors: Quantitative expression analysis and evaluation of its clinical significanceThe Prostate, 71
Panagiota Filippou, G. Karagiannis, Natasha Musrap, E. Diamandis (2016)
Kallikrein-related peptidases (KLKs) and the hallmarks of cancerCritical Reviews in Clinical Laboratory Sciences, 53
J. Hsieh, V. Le, D. Cao, E. Cheng, C. Creighton (2018)
Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan‐omics precisionThe Journal of Pathology, 244
Bin Huang, S. Fu, W. Fan, Zhongchao Wang, Ze-bin Chen, Sheng-jie Guo, Jun Chen, S. Qiu (2016)
PKCε inhibits isolation and stemness of side population cells via the suppression of ABCB1 transporter and PI3K/Akt, MAPK/ERK signaling in renal cell carcinoma cell line 769P.Cancer letters, 376 1
Feng Yang, M. Aubele, A. Walch, E. Gross, R. Napieralski, Shuo Zhao, Nancy Ahmed, M. Kiechle, U. Reuning, J. Dorn, F. Sweep, V. Magdolen, M. Schmitt (2017)
Tissue kallikrein-related peptidase 4 (KLK4), a novel biomarker in triple-negative breast cancerBiological Chemistry, 398
Z. Cui, Ye Cui, Shuting Yang, G. Luo, Yang Wang, Yixin Lou, Xinhua Sun (2017)
KLK4 silencing inhibits the growth of oral squamous cell carcinoma through Wnt/β‐catenin signaling pathwayCell Biology International, 41
O. Goldhardt, Inanna Warnhoff, I. Yakushev, I. Begčević, Hans Förstl, V. Magdolen, A. Soosaipillai, E. Diamandis, P. Alexopoulos, T. Grimmer (2019)
Kallikrein-related peptidases 6 and 10 are elevated in cerebrospinal fluid of patients with Alzheimer’s disease and associated with CSF-TAU and FDG-PETTranslational Neurodegeneration, 8
B. Tse, T. Kryza, Mei-Chun Yeh, Yingjin Dong, K. Sokolowski, C. Walpole, T. Dreyer, Johanna Felber, Jonathan Harris, V. Magdolen, P. Russell, J. Clements (2020)
KLK4 Induces Anti-Tumor Effects in Human Xenograft Mouse Models of Orthotopic and Metastatic Prostate CancerCancers, 12
Zhan Chen, Yong Zhang, Xiang Wu, Ji Zhang, Wei-Jia Xu, Chengmei Shen, B. Zheng (2021)
Gαi1 Promoted Proliferation, Migration and Invasion via Activating the Akt-mTOR/Erk-MAPK Signaling Pathway in Renal Cell CarcinomaOncoTargets and therapy, 14
Jin Gao, R. Collard, L. Bui, A. Herington, D. Nicol, J. Clements (2007)
Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancerThe Prostate, 67
F. Lose, Srilakshmi Srinivasan, T. O’Mara, L. Marquart, S. Chambers, R. Gardiner, J. Aitken, Trina Mal, T. Yeadon, Pamela Saunders, A. Eckert, Judith Clements, P. Heathcote, G. Wood, G. Malone, H. Samaratunga, Angus Collins, Megan Turner, K. Kerr, A. Spurdle, J. Batra, Judith Clements (2012)
Genetic Association of the KLK4 Locus with Risk of Prostate CancerPLoS ONE, 7
F. Bray, J. Ferlay, I. Soerjomataram, R. Siegel, Lindsey Torre, A. Jemal (2018)
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countriesCA: A Cancer Journal for Clinicians, 68
R. Siegel, K. Miller, A. Jemal (2018)
Cancer statistics, 2018CA: A Cancer Journal for Clinicians, 68
C. Ciccarese, M. Brunelli, R. Montironi, M. Fiorentino, R. Iacovelli, D. Heng, G. Tortora, F. Massari (2016)
The prospect of precision therapy for renal cell carcinoma.Cancer treatment reviews, 49
M. Perazella, R. Dreicer, M. Rosner (2018)
Renal cell carcinoma for the nephrologist.Kidney international, 94 3
W. Linehan, C. Ricketts (2019)
The Cancer Genome Atlas of renal cell carcinoma: findings and clinical implicationsNature Reviews Urology
A. Luca, M. Maiello, A. D’alessio, Maria Pergameno, N. Normanno (2012)
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approachesExpert Opinion on Therapeutic Targets, 16
C. Obiezu, A. Scorilas, Dionyssios Katsaros, Marco Massobrio, George Yousef, S. Fracchioli, I. Longrais, Riccardo Arisio, E. Diamandis (2001)
Higher human kallikrein gene 4 (KLK4) expression indicates poor prognosis of ovarian cancer patients.Clinical cancer research : an official journal of the American Association for Cancer Research, 7 8
N. Dubrawsky (1989)
Cancer statisticsCA: A Cancer Journal for Clinicians, 39
Introduction: Renal cell carcinoma (RCC) generally has a poor prognosis because of late diagnosis and metastasis. Despite its abundance in RCC cells, the functions of kallikrein-related peptidase 4 (KLK4) in RCC cells remain unknown. The results of this investigation were examined to discover if KLK4 gene silencing influences the development of RCC cells. Methods: The mRNA levels of KLK4 and the relationship between KLK4 and tumor stage in patients with RCC were analyzed from the GEPIA database. Real-time PCR and Western blotting were used to measure the mRNA and protein levels of KLK4. Cell Counting Kit 8 (CCK-8), colony formation, wound healing, and Transwell assays were used to examine the proliferation, invasion, and migration of RCC cells after KLK4 suppression. Finally, xenograft experiments in a mouse model helped understand the in vivo effects of KLK4 knockdown. Results: Our research found that KLK4 expression was upregulated in the kidney chromophobe (KICH) specimens and cell lines. Moreover, inhibiting KLK4 growth led to a slowdown in RCC cell proliferation and colony formation. Additionally, KLK4 knockdown inhibited migration, invasion, and epithelial-mesenchymal transition (EMT) of RCC cells. AKT and ERK phosphorylation were enhanced with KLK4 silencing. In the nude mouse xenograft cancer model, KLK4 silencing also prevented the expression of Ki-67, CD105, and the growth of tumors. Conclusion: KLK4 accelerated KICH progression via the ERK/AKT signaling pathway, providing a novel regulatory mechanism for KICH pathogenesis.
Kidney and Blood Pressure Research – Karger
Published: Jan 1, 2022
Keywords: KLK4; KICH; Proliferation; Migration; Invasion; EMT; ERK/AKT
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