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/lp/karger/intraokulare-penetration-systemisch-applizierter-cephalosporine-unter-N83PK2iBTp
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- Publisher
- Karger
- Copyright
- © 1985 S. Karger AG, Basel
- ISSN
- 0030-3755
- eISSN
- 1423-0267
- DOI
- 10.1159/000309535
- Publisher site
- See Article on Publisher Site
Abstract
In previous studies of intraocular penetration of systemically applied antibiotics a single dose of the antibiotic was applied. An experimental study was performed in order to determine if maintaining a constant serum level for an extended period of time will lead to an increase in ocular concentration. The antibiotic dosage was calculated so that the serum level remained constant for a given period of time. Using the rabbit as an experimental animal two cephalosporins (Cefsulodin, Cefotiam) were then injected intravenously using an infusion pump. Evaluation of serum levels (high-performance liquid chromatography) revealed constant levels for each animal but different interindividual levels. The intraocular concentrations of Cefsulodin and Cefotiam were different. The intraocular level of Cefsulodin rose continuously over a period of 5 h, whereas the Cefotiam levels remained at the concentration measured after bolus injection.
Journal
Ophthalmologica – Karger
Published: Jan 1, 2010
Keywords: Antibiotics; Cephalosporins; Intraocular pharmacokinetics; Intraocular infection; Steady state conditions