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Hyponatremia in Patients with Heart Failure beyond the Neurohormonal Activation Associated with Reduced Cardiac Output: A Holistic Approach

Hyponatremia in Patients with Heart Failure beyond the Neurohormonal Activation Associated with... Background: Heart failure (HF) is considered an epidemic disease with considerable morbidity, mortality, and immense healthcare costs. Electrolyte abnormalities are often encountered in patients with HF, posing a diagnostic and therapeutic challenge for clinicians. Hyponatremia affects up to one-third of HF patients and represents an unfavorable prognostic factor. Summary: Low sodium levels in HF are mainly attributed to the neurohormonal activation secondary to decreased effective circulating volume. However, patients with HF often have several comorbidities which may cause or exacerbate the preexisting hyponatremia. Factors that provoke HF, such as alcohol overconsumption, may also be involved in hyponatremia development. Furthermore, drugs which are frequently prescribed to HF patients, especially diuretics, are potential culprits of hyponatremia and should always be addressed since their withdrawal may reverse hyponatremia. Despite the great prevalence and deleterious effects of hyponatremia in these patients, it is often overlooked and consequently undertreated. In this review, we present the mechanisms involved in the development of hyponatremia focusing on those besides neurohormonal activation. We also discuss the proper management of this electrolyte disorder which is frequently complex in patients with HF. Key Messages: Hyponatremia in patients with HF is not only the result of neurohormonal activation; several comorbidities and frequently used drugs should also be addressed. Hence, a holistic approach is required both for the diagnosis and optimal treatment. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Cardiology Karger

Hyponatremia in Patients with Heart Failure beyond the Neurohormonal Activation Associated with Reduced Cardiac Output: A Holistic Approach

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Publisher
Karger
Copyright
© 2022 S. Karger AG, Basel
ISSN
0008-6312
eISSN
1421-9751
DOI
10.1159/000526912
Publisher site
See Article on Publisher Site

Abstract

Background: Heart failure (HF) is considered an epidemic disease with considerable morbidity, mortality, and immense healthcare costs. Electrolyte abnormalities are often encountered in patients with HF, posing a diagnostic and therapeutic challenge for clinicians. Hyponatremia affects up to one-third of HF patients and represents an unfavorable prognostic factor. Summary: Low sodium levels in HF are mainly attributed to the neurohormonal activation secondary to decreased effective circulating volume. However, patients with HF often have several comorbidities which may cause or exacerbate the preexisting hyponatremia. Factors that provoke HF, such as alcohol overconsumption, may also be involved in hyponatremia development. Furthermore, drugs which are frequently prescribed to HF patients, especially diuretics, are potential culprits of hyponatremia and should always be addressed since their withdrawal may reverse hyponatremia. Despite the great prevalence and deleterious effects of hyponatremia in these patients, it is often overlooked and consequently undertreated. In this review, we present the mechanisms involved in the development of hyponatremia focusing on those besides neurohormonal activation. We also discuss the proper management of this electrolyte disorder which is frequently complex in patients with HF. Key Messages: Hyponatremia in patients with HF is not only the result of neurohormonal activation; several comorbidities and frequently used drugs should also be addressed. Hence, a holistic approach is required both for the diagnosis and optimal treatment.

Journal

Cardiology – Karger

Published: Dec 1, 2022

Keywords: Heart failure; Sodium; Hyponatremia; Comorbidities

References

  • Electrolyte disorders in community subjects: prevalence and risk factors
    Liamis, G; Rodenburg, EM; Hofman, A; Zietse, R; Stricker, BH; Hoorn, EJ
  • Electrolyte disturbances in patients with hyponatremia
    Liamis, G; Mitrogianni, Z; Liberopoulos, EN; Tsimihodimos, V; Elisaf, M
  • Hypomagnesemia and concurrent acid-base and electrolyte abnormalities in patients with congestive heart failure
    Milionis, HJ; Alexandrides, GE; Liberopoulos, EN; Bairaktari, ET; Goudevenos, J; Elisaf, MS
  • Lower serum sodium is associated with increased short-term mortality in hospitalized patients with worsening heart failure: results from the Outcomes of a Prospective Trial of Intravenous Milrinone for Exacerbations of Chronic Heart Failure (OPTIME-CHF) study
    Klein, L; O’Connor, CM; Leimberger, JD; Gattis-Stough, W; Pina, IL; Felker, GM
  • Hyponatremia in patients hospitalized with heart failure: a condition often overlooked in low-income settings
    Ali, K; Workicho, A; Gudina, EK
  • 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure
    McDonagh, TA; Metra, M; Adamo, M; Gardner, RS; Baumbach, A; Bohm, M
  • Ten common pitfalls in the evaluation of patients with hyponatremia
    Filippatos, TD; Liamis, G; Christopoulou, F; Elisaf, MS
  • Hyponatremia in heart failure: pathogenesis and management
    Rodriguez, M; Hernandez, M; Cheungpasitporn, W; Kashani, KB; Riaz, I; Rangaswami, J
  • Hyponatremia in heart failure
    Chatterjee, K
  • Acid-base and electrolyte abnormalities in heart failure: pathophysiology and implications
    Urso, C; Brucculeri, S; Caimi, G
  • Hyponatremia and heart failure: pathophysiology and implications
    Sica, DA
  • Thirst and hydration: physiology and consequences of dysfunction
    Thornton, SN
  • Aldosterone regulates Na(+), K(+) ATPase activity in human renal proximal tubule cells through mineralocorticoid receptor
    Salyer, SA; Parks, J; Barati, MT; Lederer, ED; Clark, BJ; Klein, JD
  • Hyponatremia in patients with heart failure
    Filippatos, TD; Elisaf, MS
  • Alcohol effects on cardiac function
    Gardner, JD; Mouton, AJ
  • The sympathetic nervous system in heart failure
    Triposkiadis, F; Karayannis, G; Giamouzis, G; Skoularigis, J; Louridas, G; Butler, J
  • Angiotensin II plays a critical role in alcohol-induced cardiac nitrative damage, cell death, remodeling, and cardiomyopathy in a protein kinase C/nicotinamide adenine dinucleotide phosphate oxidase-dependent manner
    Tan, Y; Li, X; Prabhu, SD; Brittian, KR; Chen, Q; Yin, X
  • Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart
    Lang, CH; Frost, RA; Summer, AD; Vary, TC
  • The good, the bad, and the ugly with alcohol use and abuse on the heart
    Walker, RK; Cousins, VM; Umoh, NA; Jeffress, MA; Taghipour, D; Al-Rubaiee, M
  • Alcohol and apoptosis: friends or foes?
    Rodriguez, A; Chawla, K; Umoh, NA; Cousins, VM; Ketegou, A; Reddy, MG
  • Metabolic abnormalities in alcoholic patients: focus on acid base and electrolyte disorders
    Elisaf, M; Kalaitzidis, R
  • Beer potomania: an unusual cause of hyponatremia
    Kujubu, DA; Khosraviani, A
  • Reset osmostat: a challenging case of hyponatremia
    Kuthiah, N; Er, C
  • Reset osmostat: a rare cause of hyponatraemia
    Vale, BM; Morais, S; Mesquita, J; Mimoso, G
  • Oxidative myocardial damage in human cocaine-related cardiomyopathy
    Frustaci, A; Russo, MA; Morgante, E; Scopelliti, F; Aquilano, K; Ciriolo, MR
  • Mechanisms of toxic cardiomyopathy
    Hantson, P
  • Transient left ventricular apical ballooning after cocaine use: is catecholamine cardiotoxicity the pathologic link?
    Arora, S; Alfayoumi, F; Srinivasan, V
  • A case of cocaine-induced acute symptomatic hyponatraemia
    McDonald, B; Walton, M; Idowu, O; Barratt, J; Vakilgilani, T
  • Frequency of methamphetamine use as a major contributor toward the severity of cardiomyopathy in adults ≤50 years
    Neeki, MM; Kulczycki, M; Toy, J; Dong, F; Lee, C; Borger, R
  • Clinical characteristics, histopathological features, and clinical outcome of methamphetamine-associated cardiomyopathy
    Schurer, S; Klingel, K; Sandri, M; Majunke, N; Besler, C; Kandolf, R
  • Methamphetamine use and heart failure: prevalence, risk factors, and predictors
    Richards, JR; Harms, BN; Kelly, A; Turnipseed, SD
  • Hyponatremia-inducing drugs
    Liamis, G; Megapanou, E; Elisaf, M; Milionis, H
  • Olanzapine induced dilated cardiomyopathy
    Puttegowda, B; Theodore, J; Basappa, R; Nanjappa, MC
  • Suspected clozapine-induced cardiomyopathy and heart failure with reduced ejection fraction
    Patuszynski, D; Applegate, PM
  • Case report and review of the literature: cardiomyopathy in a young woman on high-dose quetiapine
    Smolders, DME; Smolders, WAP
  • Drugs and dilated cardiomyopathies: a case/noncase study in the French PharmacoVigilance database
    Montastruc, G; Favreliere, S; Sommet, A; Pathak, A; Lapeyre-Mestre, M; Perault-Pochat, MC
  • Severe acute cardiomyopathy associated with venlafaxine overdose and possible role of CYP2D6 and CYP2C19 polymorphisms
    Vinetti, M; Haufroid, V; Capron, A; Classen, JF; Marchandise, S; Hantson, P
  • Medication-induced SIADH: distribution and characterization according to medication class
    Shepshelovich, D; Schechter, A; Calvarysky, B; Diker-Cohen, T; Rozen-Zvi, B; Gafter-Gvili, A
  • A review of drug-induced hyponatremia
    Liamis, G; Milionis, H; Elisaf, M
  • Antidepressant-induced hyponatremia in older adults
    Viramontes, TS; Truong, H; Linnebur, SA
  • Hyponatremia associated with selective serotonin-reuptake inhibitors in older adults
    Jacob, S; Spinler, SA
  • A case of reversible dilated cardiomyopathy after alpha-interferon therapy in a patient with renal cell carcinoma
    Kuwata, A; Ohashi, M; Sugiyama, M; Ueda, R; Dohi, Y
  • Reversible cardiomyopathy caused by administration of interferon alpha
    Khakoo, AY; Halushka, MK; Rame, JE; Rodriguez, ER; Kasper, EK; Judge, DP
  • Drug-induced heart failure
    Feenstra, J; Grobbee, DE; Remme, WJ; Stricker, BH
  • Drug-induced mitochondrial dysfunction and cardiotoxicity
    Varga, ZV; Ferdinandy, P; Liaudet, L; Pacher, P
  • Electrolyte disorders associated with the use of anticancer drugs
    Liamis, G; Filippatos, TD; Elisaf, MS
  • Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management
    Yeh, ET; Tong, AT; Lenihan, DJ; Yusuf, SW; Swafford, J; Champion, C
  • High-dose ifosfamide is associated with severe, reversible cardiac dysfunction
    Quezado, ZM; Wilson, WH; Cunnion, RE; Parker, MM; Reda, D; Bryant, G
  • Non-steroidal anti-inflammatory drugs and risk of first hospital admission for heart failure in the general population
    Huerta, C; Varas-Lorenzo, C; Castellsague, J; Garcia Rodriguez, LA
  • Drugs that may cause or exacerbate heart failure: a scientific statement from the American heart association
    Page, RL; O’Bryant, CL; Cheng, D; Dow, TJ; Ky, B; Stein, CM
  • 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC
    Ponikowski, P; Voors, AA; Anker, SD; Bueno, H; Cleland, JGF; Coats, AJS
  • Treating volume overload in acutely decompensated heart failure: established and novel therapeutic approaches
    Koniari, K; Parissis, J; Paraskevaidis, I; Anastasiou-Nana, M
  • Hyponatremia in patients with infectious diseases
    Liamis, G; Milionis, HJ; Elisaf, M
  • Intricacies of cardiac damage in coxsackievirus B3 infection: implications for therapy
    Massilamany, C; Gangaplara, A; Reddy, J
  • Diagnosis and management of nephrotic syndrome in adults
    Kodner, C
  • HBV induces different responses of the hepatocytes and oval cells during HBV-related hepatic cirrhosis
    Zhang, L; Chen, Y; Zhang, LJ; Wang, M; Chang, DL; Wan, WW
  • Hyponatremia in children with tuberculous meningitis: a hospital-based cohort study
    Inamdar, P; Masavkar, S; Shanbag, P
  • A study of neuroendocrine dysfunction in patients of tuberculous meningitis
    More, A; Verma, R; Garg, RK; Malhotra, HS; Sharma, PK; Uniyal, R
  • Inappropriate antidiuretic hormone secretion and cerebral salt-wasting syndromes in neurological patients
    Cui, H; He, G; Yang, S; Lv, Y; Jiang, Z; Gang, X
  • Hyponatremia and inflammation: the emerging role of interleukin-6 in osmoregulation
    Swart, RM; Hoorn, EJ; Betjes, MG; Zietse, R
  • Hyponatremia, IL-6, and SARS-CoV-2 (COVID-19) infection: may all fit together?
    Berni, A; Malandrino, D; Parenti, G; Maggi, M; Poggesi, L; Peri, A
  • IL-6: relevance for immunopathology of SARS-CoV-2
    Gubernatorova, EO; Gorshkova, EA; Polinova, AI; Drutskaya, MS
  • Adrenal cortical insufficiency: a life threatening illness with multiple etiologies
    Quinkler, M; Beuschlein, F; Hahner, S; Meyer, G; Schofl, C; Stalla, GK
  • A descriptive study of adrenal crises in adults with adrenal insufficiency: increased risk with age and in those with bacterial infections
    Rushworth, RL; Torpy, DJ
  • Adrenal insufficiency in Pakistani Hiv infected patients
    Afreen, B; Khan, KA; Riaz, A
  • Trimethoprim-associated hyponatremia
    Babayev, R; Terner, S; Chandra, S; Radhakrishnan, J; Mohan, S
  • Hyponatremia in diabetes mellitus: clues to diagnosis and treatment
    Vasilios, GL
  • Diagnosis and classification of Addison’s disease (autoimmune adrenalitis)
    Brandao Neto, RA; de Carvalho, JF
  • Spurious electrolyte disorders: a diagnostic challenge for clinicians
    Liamis, G; Liberopoulos, E; Barkas, F; Elisaf, M
  • Heart failure not responsive to standard immunosuppressive therapy is successfully treated with high dose intravenous immunoglobulin therapy in a patient with Eosinophilic Granulomatosis with Polyangiitis (EGPA)
    Pecoraro, A; Crescenzi, L; Carucci, L; Genovese, A; Spadaro, G
  • Glycogen storage disease type III
    Dagli, A; Sentner, CP; Weinstein, DA; Adam, MP; Ardinger, HH; Pagon, RA; Wallace, SE; Bean, LJH; Stephens, K
  • Serum electrolyte levels in relation to macrovascular complications in Chinese patients with diabetes mellitus
    Wang, S; Hou, X; Liu, Y; Lu, H; Wei, L; Bao, Y
  • Changing epidemiology of type 2 diabetes mellitus and associated chronic kidney disease
    Thomas, MC; Cooper, ME; Zimmet, P
  • Hyporeninemic hypoaldosteronism and diabetes mellitus: pathophysiology assumptions, clinical aspects and implications for management
    Sousa, AG; Cabral, JV; El-Feghaly, WB; de Sousa, LS; Nunes, AB
  • Treating painful diabetic peripheral neuropathy: an update
    Snyder, MJ; Gibbs, LM; Lindsay, TJ
  • Insulin potentiates AVP-induced AQP2 expression in cultured renal collecting duct principal cells
    Bustamante, M; Hasler, U; Kotova, O; Chibalin, AV; Mordasini, D; Rousselot, M
  • Diabetes mellitus and electrolyte disorders
    Liamis, G; Liberopoulos, E; Barkas, F; Elisaf, M
  • Origin and therapy for hypertriglyceridaemia in type 2 diabetes
    Pang, J; Chan, DC; Watts, GF
  • Role of thyroid hormones in different aspects of cardiovascular system
    Hernando, VU
  • Management of endrocine disease: hypothyroidism-associated hyponatremia: mechanisms, implications and treatment
    Liamis, G; Filippatos, TD; Liontos, A; Elisaf, MS
  • Addison’s disease and dilated cardiomyopathy: a case report and review of the literature
    Mozolevska, V; Schwartz, A; Cheung, D; Shaikh, B; Bhagirath, KM; Jassal, DS
  • Endocrine disorders: causes of hyponatremia not to neglect
    Liamis, G; Milionis, HJ; Elisaf, M
  • The challenge of cardiomyopathies and heart failure in pregnancy
    Limongelli, G; Rubino, M; Esposito, A; Russo, M; Pacileo, G
  • A modified definition for peripartum cardiomyopathy and prognosis based on echocardiography
    Hibbard, JU; Lindheimer, M; Lang, RM
  • Pre-eclampsia and heart failure: a close relationship
    Orabona, R; Sciatti, E; Prefumo, F; Vizzardi, E; Bonadei, I; Valcamonico, A
  • Renal physiology and fluid and electrolyte disorders in pregnancy
    Belzile, M; Pouliot, A; Cumyn, A; Cote, AM
  • Approach to the diagnosis and treatment of hyponatremia in pregnancy
    Pazhayattil, GS; Rastegar, A; Brewster, UC
  • Reset osmostat in pregnancy: a case report
    Harris, K; Shankar, R; Black, K; Rochelson, B
  • Prevalence of cachexia in chronic heart failure and characteristics of body composition and metabolic status
    Christensen, HM; Kistorp, C; Schou, M; Keller, N; Zerahn, B; Frystyk, J
  • Altered intestinal function in patients with chronic heart failure
    Sandek, A; Bauditz, J; Swidsinski, A; Buhner, S; Weber-Eibel, J; von Haehling, S
  • Malnutrition and cachexia in heart failure
    Rahman, A; Jafry, S; Jeejeebhoy, K; Nagpal, AD; Pisani, B; Agarwala, R
  • Cardiac cachexia: perspectives for prevention and treatment
    Okoshi, MP; Capalbo, RV; Romeiro, FG; Okoshi, K
  • Elevated circulating levels of tumor necrosis factor in severe chronic heart failure
    Levine, B; Kalman, J; Mayer, L; Fillit, HM; Packer, M
  • “Beer potomania” in non-beer drinkers: effect of low dietary solute intake
    Thaler, SM; Teitelbaum, I; Berl, T
  • Reduction of dietary sodium to less than 100 mmol in heart failure (SODIUM-HF): an international, open-label, randomised, controlled trial
    Ezekowitz, JA; Colin-Ramirez, E; Ross, H; Escobedo, J; Macdonald, P; Troughton, R
  • Shared risk factors in cardiovascular disease and cancer
    Koene, RJ; Prizment, AE; Blaes, A; Konety, SH
  • Cancer statistics, 2018
    Siegel, RL; Miller, KD; Jemal, A
  • Patients with heart failure have an increased risk of incident cancer
    Hasin, T; Gerber, Y; McNallan, SM; Weston, SA; Kushwaha, SS; Nelson, TJ
  • Predicting the risk of cardiovascular comorbidities in adult cancer survivors
    Tashakkor, AY; Moghaddamjou, A; Chen, L; Cheung, WY
  • Cancer therapy-related cardiac dysfunction and heart failure: Part 1: definitions, pathophysiology, risk factors, and imaging
    Bloom, MW; Hamo, CE; Cardinale, D; Ky, B; Nohria, A; Baer, L
  • Management of heart failure in cancer patients and cancer survivors
    Finet, JE
  • A prospective study on hyponatraemia in medical cancer patients: epidemiology, aetiology and differential diagnosis
    Berghmans, T; Paesmans, M; Body, JJ
  • Diagnosis and management of hyponatremia in cancer patients
    Castillo, JJ; Vincent, M; Justice, E
  • Hyponatremia in hospitalized cancer patients and its impact on clinical outcomes
    Doshi, SM; Shah, P; Lei, X; Lahoti, A; Salahudeen, AK
  • The occurrence of hyponatremia and its importance as a prognostic factor in a cross-section of cancer patients
    Castillo, JJ; Glezerman, IG; Boklage, SH; Chiodo, J; Tidwell, BA; Lamerato, LE
  • Tumor-related hyponatremia
    Onitilo, AA; Kio, E; Doi, SA
  • A metabolic study of patients with lung cancer and hyponatremia of malignancy
    Chute, JP; Taylor, E; Williams, J; Kaye, F; Venzon, D; Johnson, BE
  • An integrated analysis of hyponatremia in cancer patients receiving platinum-based or nonplatinum-based chemotherapy in clinical trials (JCOG1405-A)
    Ezoe, Y; Mizusawa, J; Katayama, H; Kataoka, K; Muto, M
  • Risk of hyponatraemia in cancer patients treated with targeted therapies: a systematic review and meta-analysis of clinical trials
    Berardi, R; Santoni, M; Rinaldi, S; Nunzi, E; Smerilli, A; Caramanti, M
  • Hyponatremia normalization as an independent prognostic factor in patients with advanced non-small cell lung cancer treated with first-line therapy
    Berardi, R; Santoni, M; Newsom-Davis, T; Caramanti, M; Rinaldi, S; Tiberi, M
  • Diagnosis and management of hyponatremia in cancer patients
    Raftopoulos, H
  • Bilateral primary adrenal lymphoma with adrenal insufficiency
    Ekhzaimy, A; Mujamammi, A
  • Adrenal crisis in metastatic breast cancer
    Doleschal, B; Petzer, A; Aichberger, KJ
  • Development of severe hyponatraemia in hospitalized patients: treatment-related risk factors and inadequate management
    Hoorn, EJ; Lindemans, J; Zietse, R
  • Heart failure in acute ischemic stroke
    Cuadrado-Godia, E; Ois, A; Roquer, J
  • Heart failure and the risk of ischemic stroke recurrence: a systematic review and meta-analysis
    Katsanos, AH; Parissis, J; Frogoudaki, A; Vrettou, AR; Ikonomidis, I; Paraskevaidis, I
  • Hyponatremia in acute stroke patients: pathophysiology, clinical significance, and management options
    Liamis, G; Barkas, F; Megapanou, E; Christopoulou, E; Makri, A; Makaritsis, K
  • Cerebral salt wasting is the most common cause of hyponatremia in stroke
    Kalita, J; Singh, RK; Misra, UK
  • Depression in chronic heart failure: novel pathophysiological mechanisms and therapeutic approaches
    Parissis, JT; Fountoulaki, K; Paraskevaidis, I; Kremastinos, D
  • Depression, healthcare utilization, and death in heart failure: a community study
    Moraska, AR; Chamberlain, AM; Shah, ND; Vickers, KS; Rummans, TA; Dunlay, SM
  • Uric acid in cachectic and noncachectic patients with chronic heart failure: relationship to leg vascular resistance
    Doehner, W; Rauchhaus, M; Florea, VG; Sharma, R; Bolger, AP; Davos, CH
  • Incident heart failure in patients with rheumatoid arthritis: a nationwide cohort study
    Khalid, U; Egeberg, A; Ahlehoff, O; Lane, D; Gislason, GH; Lip, GYH
  • Association between rheumatoid arthritis and risk of ischemic and nonischemic heart failure
    Mantel, A; Holmqvist, M; Andersson, DC; Lund, LH; Askling, J
  • Chronic kidney disease and cardiovascular disease
    Bondugulapati, LNR; Shandilya, S
  • Dysnatremias in patients with kidney disease
    Combs, S; Berl, T
  • Comorbidities in heart failure
    van der Wal, HH; van Deursen, VM; van der Meer, P; Voors, AA
  • Infection in patients with decompensated heart failure: in-hospital mortality and outcome
    Cardoso, JN; Del Carlo, CH; Oliveira Junior, MT; Ochiai, ME; Kalil Filho, R; Barretto, ACP
  • Hyponatremia in COPD: a little known complication
    Martín Guerra, JM; Martín Asenjo, M; Sánchez Muñoz, LÁ; Dueñas Gutiérrez, CJ
  • Water and sodium imbalance in COPD patients
    Valli, G; Fedeli, A; Antonucci, R; Paoletti, P; Palange, P
  • Syndrome of inappropriate antidiuretic hormone production caused by multiple factors
    Smith, HD; Kelly, CW; DiCocco, M
  • Hyponatremia and increased exchangeable sodium in chronic obstructive lung disease
    Bauer, FK; Telfer, N; Herbst, HH; Austin, RC; Hetter, B
  • Hyponatremia in patients with liver diseases: not just a cirrhosis-induced hemodynamic compromise
    Liamis, G; Filippatos, TD; Liontos, A; Elisaf, MS
  • The progression from hypertension to congestive heart failure
    Levy, D; Larson, MG; Vasan, RS; Kannel, WB; Ho, KK
  • The transition from hypertension to heart failure: contemporary update
    Messerli, FH; Rimoldi, SF; Bangalore, S
  • Heart failure and hypertension: importance of prevention
    Pfeffer, MA
  • Hypertension and heart failure with preserved ejection fraction: connecting the dots
    Tsioufis, C; Georgiopoulos, G; Oikonomou, D; Thomopoulos, C; Katsiki, N; Kasiakogias, A
  • Blood pressure drug therapy and electrolyte disturbances
    Liamis, G; Milionis, H; Elisaf, M
  • Thiazide-associated hyponatremia in the elderly: what the clinician needs to know
    Liamis, G; Filippatos, TD; Elisaf, MS
  • Diuretics in the treatment of hypertension. Part 1: thiazide and thiazide-like diuretics
    Tamargo, J; Segura, J; Ruilope, LM
  • Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2
    Frenkel, NJ; Vogt, L; De Rooij, SE; Trimpert, C; Levi, MM; Deen, PM
  • Diuretic-related side effects: development and treatment
    Sica, DA
  • Usefulness of spironolactone in a specialized heart failure clinic
    Sligl, W; McAlister, FA; Ezekowitz, J; Armstrong, PW
  • Pharmacological management of hyponatremia
    Filippatos, T; Elisaf, M; Liamis, G
  • Syndrome of inappropriate secretion of antidiuretic hormone associated with angiotensin-converting enzyme inhibitor administration
    Murakami, T; Horibata, Y; Morimoto, Y; Tateno, S; Kawasoe, Y; Niwa, K
  • Sacubitril/valsartan (entresto(R))-Induced hyponatremia
    Fuzaylova, I; Lam, C; Talreja, O; Makaryus, AN; Ahern, D; Cassagnol, M
  • B-type natriuretic peptide during treatment with sacubitril/valsartan: the PARADIGM-HF trial
    Myhre, PL; Vaduganathan, M; Claggett, B; Packer, M; Desai, AS; Rouleau, JL
  • Hyponatremia during hospitalization and in-hospital mortality in patients hospitalized from heart failure
    Saepudin, S; Ball, PA; Morrissey, H
  • Heparin-induced hyponatremia
    Norman, NE; Sneed, AM; Brown, C; Ellis, CA; Minard, G; Brown, RO
  • Hyponatremia after anticoagulant treatment: a rare cause of adrenal failure
    Zampetti, B; Attanasio, R; Cozzi, R
  • Epidemiology and risk profile of heart failure
    Bui, AL; Horwich, TB; Fonarow, GC
  • Prevalence and prognostic significance of hyponatraemia in outpatients with chronic heart failure
    Balling, L; Schou, M; Videbaek, L; Hildebrandt, P; Wiggers, H; Gustafsson, F
  • Prognostic impact of hyponatremia and hypernatremia at admission and discharge in heart failure patients with preserved, mid-range, and reduced ejection fraction
    Vicent, L; Alvarez-Garcia, J; Gonzalez-Juanatey, JR; Rivera, M; Segovia, J; Worner, F
  • Improvement of hyponatremia is associated with lower mortality risk in patients with acute decompensated heart failure: a meta-analysis of cohort studies
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  • Correction of hypovolemia with crystalloid fluids: Individualizing infusion therapy
    Liamis, G; Filippatos, TD; Elisaf, MS
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    Kinugawa, K; Sato, N; Inomata, T; Yasuda, M; Shimakawa, T; Fukuta, Y