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Experimental Studies on the Accumulation of Subretinal Fluid

Experimental Studies on the Accumulation of Subretinal Fluid In an attempt to develop a rabbit model for serous detachment, we damaged the pigment epithelium with low-intensity laser burns, lowered intraoccular pressure and administered dibutyryl adenosine 3′,5′-cyclic phosphate (cAMP), to inhibit pigment epithelial water transport. We produced only small areas of edema or very low detachment that persisted for a few days at best. These experiments suggest that it is remarkably difficult to make fluid stay in the subretinal space, and more stringent conditions will be needed to mimic the size and persistence of clinical serous detachments. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ophthalmologica Karger

Experimental Studies on the Accumulation of Subretinal Fluid

Ophthalmologica , Volume 202 (4): 6 – Jan 1, 2010

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Publisher
Karger
Copyright
© 1991 S. Karger AG, Basel
ISSN
0030-3755
eISSN
1423-0267
DOI
10.1159/000310200
Publisher site
See Article on Publisher Site

Abstract

In an attempt to develop a rabbit model for serous detachment, we damaged the pigment epithelium with low-intensity laser burns, lowered intraoccular pressure and administered dibutyryl adenosine 3′,5′-cyclic phosphate (cAMP), to inhibit pigment epithelial water transport. We produced only small areas of edema or very low detachment that persisted for a few days at best. These experiments suggest that it is remarkably difficult to make fluid stay in the subretinal space, and more stringent conditions will be needed to mimic the size and persistence of clinical serous detachments.

Journal

OphthalmologicaKarger

Published: Jan 1, 2010

Keywords: Serous retinal detachment; Non rhegmatogenous detachment; Subretinal fluid; Retinal pigment epithelium

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