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Exclusion of Influences of ARMS2 Polymorphisms on the Central Visual Field in Retinitis Pigmentosa

Exclusion of Influences of ARMS2 Polymorphisms on the Central Visual Field in Retinitis Pigmentosa Purpose: To investigate the effects of polymorphisms of the age-related maculopathy susceptibility 2 (ARMS2) gene on the central visual field defects in retinitis pigmentosa (RP). Subjects and Methods: The visual field was evaluated using the 10-2 Swedish Interactive Threshold Algorithm Fast Program and mean deviation (MD) slope, and regression coefficients of average sensitivity of the central 4 points (Cent4) were compared between each genetic subgroup. Results: The MD slope (right/left) was as follows: GG, -1.37 ± 2.18/ -0.89 ± 1.15; GT, -0.56 ± 1.40/-0.77 ± 1.04; TT, -0.75 ± 0.64/ -0.38 ± 0.92 dB/year. The Cent4 was as follows: GG, -1.34 ± 2.37/-1.60 ± 3.21; GT, -1.15 ± 2.08/1.07 ± 1.80; TT, -1.20 ± 0.91/-0.65 ± 1.37 dB/year. No significant differences in the degree of progression were observed when comparing groups. Conclusions: These data suggest that polymorphisms of the ARMS2 do not modify the progression of the central field of vision in RP patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ophthalmologica Karger

Exclusion of Influences of ARMS2 Polymorphisms on the Central Visual Field in Retinitis Pigmentosa

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Publisher
Karger
Copyright
© 2013 S. Karger AG, Basel
ISSN
0030-3755
eISSN
1423-0267
DOI
10.1159/000355093
Publisher site
See Article on Publisher Site

Abstract

Purpose: To investigate the effects of polymorphisms of the age-related maculopathy susceptibility 2 (ARMS2) gene on the central visual field defects in retinitis pigmentosa (RP). Subjects and Methods: The visual field was evaluated using the 10-2 Swedish Interactive Threshold Algorithm Fast Program and mean deviation (MD) slope, and regression coefficients of average sensitivity of the central 4 points (Cent4) were compared between each genetic subgroup. Results: The MD slope (right/left) was as follows: GG, -1.37 ± 2.18/ -0.89 ± 1.15; GT, -0.56 ± 1.40/-0.77 ± 1.04; TT, -0.75 ± 0.64/ -0.38 ± 0.92 dB/year. The Cent4 was as follows: GG, -1.34 ± 2.37/-1.60 ± 3.21; GT, -1.15 ± 2.08/1.07 ± 1.80; TT, -1.20 ± 0.91/-0.65 ± 1.37 dB/year. No significant differences in the degree of progression were observed when comparing groups. Conclusions: These data suggest that polymorphisms of the ARMS2 do not modify the progression of the central field of vision in RP patients.

Journal

OphthalmologicaKarger

Published: Jan 1, 2013

Keywords: Retinitis pigmentosa; A69S; ARMS2 gene; Mean deviation slope; Polymorphism; Visual field

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