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Determination of a New Cut-Off Value for the Urinary BTAtrak to Optimize the Detection of Recurrences in the Follow-Up of Patients with Superficial Bladder Carcinoma

Determination of a New Cut-Off Value for the Urinary BTAtrak to Optimize the Detection of... The present study aimed to prospectivelyreassess the cut-off value of the urinary BTAtrak assayin order to optimize the detection of high and middlerisk recurrent tumors during the follow-up of superficialbladder cancer. Patients and Methods: We prospectivelyinvestigated sensitivity and specificity values of BTAtrak(cut-off: 8 U/ml), cytology, hemoglobin dipstick and theircombinations in 956 patients monitored for bladdercancer recurrence. All of the patients (n = 2) with upperurinary tract tumours (UUTT) showed a positive BTAtrakand were not included in the study. We found 215 bladderneoplasms, 149 were papillary and the remaining 66 weresolid tumors. There were 115 (53.5%) single tumors and100 (46.5%) multiple tumors. The mean size of the tumorswas 1.78 ± 1.8 cm with 80 (37.2%) minor than 0.5 cm, 103(47.9%) from 0.5 to 3 cm and 32 (14.9%) tumors greaterthan 3 cm. Results: BTAtrak (cut-off: 8 U/ml) plus cytologydemonstrated the highest overall sensitivity and detectedall high-risk tumors (Ta-1G3/Tis and T2-4). Specificityincreased considerably when radiotherapy, urinary tractinfection (UTI), urethral catherization as well as intravesicalinstillations within 3 months before BTAtrak determinationwere not included. The combinations of cytology andBTAtrak resulted negative in 42.6% of cases with a BTAtrakcut-off of 8 U/ml. Conclusion: The combination ofcytology and BTAtrak using a lower cut-off level (8 U/ml)demonstrated to be a very sensitive marker to detectmost of dangerous tumors in the follow-up of superficialbladder cancer. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Urology Karger

Determination of a New Cut-Off Value for the Urinary BTAtrak to Optimize the Detection of Recurrences in the Follow-Up of Patients with Superficial Bladder Carcinoma

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Publisher
Karger
Copyright
© 2007 S. Karger AG, Basel
ISSN
1661-7649
eISSN
1661-7657
DOI
10.1159/000106528
Publisher site
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Abstract

The present study aimed to prospectivelyreassess the cut-off value of the urinary BTAtrak assayin order to optimize the detection of high and middlerisk recurrent tumors during the follow-up of superficialbladder cancer. Patients and Methods: We prospectivelyinvestigated sensitivity and specificity values of BTAtrak(cut-off: 8 U/ml), cytology, hemoglobin dipstick and theircombinations in 956 patients monitored for bladdercancer recurrence. All of the patients (n = 2) with upperurinary tract tumours (UUTT) showed a positive BTAtrakand were not included in the study. We found 215 bladderneoplasms, 149 were papillary and the remaining 66 weresolid tumors. There were 115 (53.5%) single tumors and100 (46.5%) multiple tumors. The mean size of the tumorswas 1.78 ± 1.8 cm with 80 (37.2%) minor than 0.5 cm, 103(47.9%) from 0.5 to 3 cm and 32 (14.9%) tumors greaterthan 3 cm. Results: BTAtrak (cut-off: 8 U/ml) plus cytologydemonstrated the highest overall sensitivity and detectedall high-risk tumors (Ta-1G3/Tis and T2-4). Specificityincreased considerably when radiotherapy, urinary tractinfection (UTI), urethral catherization as well as intravesicalinstillations within 3 months before BTAtrak determinationwere not included. The combinations of cytology andBTAtrak resulted negative in 42.6% of cases with a BTAtrakcut-off of 8 U/ml. Conclusion: The combination ofcytology and BTAtrak using a lower cut-off level (8 U/ml)demonstrated to be a very sensitive marker to detectmost of dangerous tumors in the follow-up of superficialbladder cancer.

Journal

Current Urology – Karger

Published: Jan 1, 2007

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