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Congenital Aphakia

Congenital Aphakia Netherl. Op h th al . Soc., 149th Meeting, R o tt e r d a m 1962 Op ht ha lino lo gic a 145 :4 6 0 (1963) By W . A. MANSCHOT (Rotterdam ) S u m m a r y T h e h istological d e scrip tio n of a case of b ila te ra l m ic ro p h th a l­ m ia in a p re m a tu re ch ild w eig h in g 2100 g w ith o th e r congenital anom alies, w ho died soon a fte r b irth . The a n te rio r w all of the b u lb u s w as covered w ith ty p ical corneal ep ith eliu m , b u t Bow ­ m a n ’s m em b ran e, D escem et’s m em b ran e, a n d e n d o th eliu m were absent. T h e a n te rio r c h a m b e r, iris, lens, an d zonule w ere also a b ­ sent. A colobom a w as p rese n t in th e a n te rio r in fe rio r p a rt of the eye. (P u b lis h e d in e x te n so e lsew h ere) D i s c u s s i o n W a a rd e n b u rg co n g ra t u la t es M a n s c h o t on his interesting case a n d his kno w ledge o f the li ter atu re. It is true th a t congenital a p h a k i a is fre quen tly a s s u m e d w ith ou t jus tificatio n. This case is instructive b eca us e it gives us in ­ f o r m a t i o n a b o u t the o r d e r o f in d u ct io n in the e m bry onic dev elopm en t of the eye. W e see th a t a co rn ea , even if it is a b n o rm a l, can be pro d u c e d , a lt h o u g h no lens o r o th e r in te rn al o c u la r s t ru c tu r e s ar e formed. H a g ed o o rn : I was p a rt ic u l a rl y intereste d to note that the ganglion cells a n d nerve fibres w e re abse nt. T h e o t h e r ret ina l elements were, howeve r, fairly well developed. In the cuttle-fish, the optic gan gli on lies behind a n eye w it h a re t in a of si mi lar co n st ru c ti o n (“c o n v er g en ce ”) w it h o u t ganglion cells. In Vertebrates, the optic placode is included in th e n eu ra l tube, w h e re n a tu r a ll y the n er vous “ganglion o p ticu m Anlage” m u s t also be situated. Your p r e p a r a t i o n suggests th a t this theoretical s e p a r a ti o n of th e two ele­ m en ts in V er tebra tes is als o pre s en t in man. Following W a a r d e n b u rg ’s train of thou ght , one m a y a ss u m e that the m o t h e r cells of these gan gli on cells pass t h r o u g h the stem of the optic cup to the r u d i m e n t a r y sense o rg an , the eye, and th a t this has n ot o c c u rr e d in this case. A point in f av our of this th e o r y is that the stem of the opti c cup is r e m a r k a b l y full of cells in a n o rm a ll y developing eye. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ophthalmologica Karger

Congenital Aphakia

Manschot, W.A.
Ophthalmologica , Volume 145 (6): 1 – Jan 1, 2010
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Publisher
Karger
Copyright
© 1963 S. Karger AG, Basel
ISSN
0030-3755
eISSN
1423-0267
DOI
10.1159/000304480
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Abstract

Netherl. Op h th al . Soc., 149th Meeting, R o tt e r d a m 1962 Op ht ha lino lo gic a 145 :4 6 0 (1963) By W . A. MANSCHOT (Rotterdam ) S u m m a r y T h e h istological d e scrip tio n of a case of b ila te ra l m ic ro p h th a l­ m ia in a p re m a tu re ch ild w eig h in g 2100 g w ith o th e r congenital anom alies, w ho died soon a fte r b irth . The a n te rio r w all of the b u lb u s w as covered w ith ty p ical corneal ep ith eliu m , b u t Bow ­ m a n ’s m em b ran e, D escem et’s m em b ran e, a n d e n d o th eliu m were absent. T h e a n te rio r c h a m b e r, iris, lens, an d zonule w ere also a b ­ sent. A colobom a w as p rese n t in th e a n te rio r in fe rio r p a rt of the eye. (P u b lis h e d in e x te n so e lsew h ere) D i s c u s s i o n W a a rd e n b u rg co n g ra t u la t es M a n s c h o t on his interesting case a n d his kno w ledge o f the li ter atu re. It is true th a t congenital a p h a k i a is fre quen tly a s s u m e d w ith ou t jus tificatio n. This case is instructive b eca us e it gives us in ­ f o r m a t i o n a b o u t the o r d e r o f in d u ct io n in the e m bry onic dev elopm en t of the eye. W e see th a t a co rn ea , even if it is a b n o rm a l, can be pro d u c e d , a lt h o u g h no lens o r o th e r in te rn al o c u la r s t ru c tu r e s ar e formed. H a g ed o o rn : I was p a rt ic u l a rl y intereste d to note that the ganglion cells a n d nerve fibres w e re abse nt. T h e o t h e r ret ina l elements were, howeve r, fairly well developed. In the cuttle-fish, the optic gan gli on lies behind a n eye w it h a re t in a of si mi lar co n st ru c ti o n (“c o n v er g en ce ”) w it h o u t ganglion cells. In Vertebrates, the optic placode is included in th e n eu ra l tube, w h e re n a tu r a ll y the n er vous “ganglion o p ticu m Anlage” m u s t also be situated. Your p r e p a r a t i o n suggests th a t this theoretical s e p a r a ti o n of th e two ele­ m en ts in V er tebra tes is als o pre s en t in man. Following W a a r d e n b u rg ’s train of thou ght , one m a y a ss u m e that the m o t h e r cells of these gan gli on cells pass t h r o u g h the stem of the optic cup to the r u d i m e n t a r y sense o rg an , the eye, and th a t this has n ot o c c u rr e d in this case. A point in f av our of this th e o r y is that the stem of the opti c cup is r e m a r k a b l y full of cells in a n o rm a ll y developing eye.

Journal

Ophthalmologica – Karger

Published: Jan 1, 2010

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