Access the full text.
Sign up today, get DeepDyve free for 14 days.
J. Kobayashi, Takeyoshi Sasaki, M. Watanabe (2004)
The relationship of abdominal fat mass assessed by helical or conventional computed tomography to serum leptin concentration.Journal of atherosclerosis and thrombosis, 11 3
T. Oh, J. Byeon, S. Myung, Suk-Kyun Yang, Kwi-Sook Choi, Jun-Won Chung, Benjamin Kim, Don Lee, Jae Byun, S. Jang, Jin-Ho Kim (2008)
Visceral obesity as a risk factor for colorectal neoplasmJournal of Gastroenterology and Hepatology, 23
A. Lihn, S. Pedersen, B. Richelsen (2005)
Adiponectin: action, regulation and association to insulin sensitivityObesity Reviews, 6
Caroline Fox, Joseph Massaro, U. Hoffmann, Karla Pou, P. Maurovich-Horvat, Chunyu Liu, R. Vasan, J. Murabito, J. Meigs, L. Cupples, Ralph D’Agostino, Christopher O’Donnell (2007)
Abdominal Visceral and Subcutaneous Adipose Tissue Compartments: Association With Metabolic Risk Factors in the Framingham Heart StudyCirculation, 116
V. Setiawan, D. Stram, A. Nomura, L. Kolonel, B. Henderson (2007)
Risk factors for renal cell cancer: the multiethnic cohort.American journal of epidemiology, 166 8
A. Volpe, T. Panzarella, R. Rendon, M. Haider, F. Kondylis, M. Jewett (2004)
The natural history of incidentally detected small renal massesCancer, 100
A. Horiguchi, M. Sumitomo, J. Asakuma, T. Asano, Rong Zheng, T. Asano, D. Nanus, M. Hayakawa (2006)
Increased serum leptin levels and over expression of leptin receptors are associated with the invasion and progression of renal cell carcinoma.The Journal of urology, 176 4 Pt 1
T. Kadowaki, T. Yamauchi, N. Kubota, K. Hara, K. Ueki, K. Tobe (2006)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome.The Journal of clinical investigation, 116 7
Miwa Ryo, Tadashi Nakamura, S. Kihara, M. Kumada, S. Shibazaki, Mihoko Takahashi, M. Nagai, Y. Matsuzawa, T. Funahashi (2004)
Adiponectin as a biomarker of the metabolic syndrome.Circulation journal : official journal of the Japanese Circulation Society, 68 11
J. Kobayashi, N. Tadokoro, M. Watanabe, M. Shinomiya (2002)
A novel method of measuring intra-abdominal fat volume using helical computed tomographyInternational Journal of Obesity, 26
K. Kwon, S. Jung, Chulhee Choi, S. Park (2005)
Reciprocal association between visceral obesity and adiponectin: in healthy premenopausal women.International journal of cardiology, 101 3
E. Brakenhielm, N. Veitonmäki, R. Cao, S. Kihara, Y. Matsuzawa, B. Zhivotovsky, T. Funahashi, Yihai Cao (2004)
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.Proceedings of the National Academy of Sciences of the United States of America, 101 8
Enzo Bonora, Enzo Bonora, Enzo Bonora, R. Micciolo, R. Micciolo, R. Micciolo, Abraham Ghiatas, Abraham Ghiatas, Abraham Ghiatas, Jack Lancaster, Jack Lancaster, Jack Lancaster, Abdalmajed Alyassin, Abdalmajed Alyassin, Abdalmajed Alyassin, Michele Muggeo, Michele Muggeo, Michele Muggeo, R. DeFronzo, Ralph DeFronzo, Ralph DeFronzo (1995)
Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements?Metabolism: clinical and experimental, 44 12
L. Schips, K. Lipsky, R. Zigeuner, S. Gidaro, Michael Salfellner, P. Rehak, K. Pummer, G. Hubmer (2004)
Does overweight impact on the prognosis of patients with renal cell carcinoma? A single center experience of 683 patientsJournal of Surgical Oncology, 88
A. Parker, C. Lohse, J. Cheville, D. Thiel, B. Leibovich, M. Blute (2006)
Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma.Urology, 68 4
Y. Iwashima, T. Horio, M. Kumada, Yoshihiko Suzuki, S. Kihara, H. Rakugi, Y. Kawano, T. Funahashi, T. Ogihara (2006)
Adiponectin and renal function, and implication as a risk of cardiovascular disease.The American journal of cardiology, 98 12
W. Chow, G. Gridley, J. Fraumeni, B. Järvholm (2000)
Obesity, hypertension, and the risk of kidney cancer in men.The New England journal of medicine, 343 18
B. Rini, E. Small (2005)
Biology and clinical development of vascular endothelial growth factor-targeted therapy in renal cell carcinoma.Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 23 5
V. Costes, Janny, Liautard, M. Picot, M. Robert, N. Lequeux, J. Brochier, P. Baldet, Jean-Fransois Rossi (1997)
Expression of the interleukin 6 receptor in primary renal cell carcinoma.Journal of Clinical Pathology, 50
A. Cartier, I. Lemieux, N. Alméras, A. Tremblay, J. Bergeron, J. Despres (2008)
Visceral obesity and plasma glucose-insulin homeostasis: contributions of interleukin-6 and tumor necrosis factor-alpha in men.The Journal of clinical endocrinology and metabolism, 93 5
B. Wajchenberg, Daniel Giannella-Neto, M. Silva, R. Santos (2002)
Depot-specific hormonal characteristics of subcutaneous and visceral adipose tissue and their relation to the metabolic syndrome.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 34 11-12
Lei Li, Ye Gao, Lin-lin Zhang, D. He (2008)
Concomitant activation of the JAK/STAT3 and ERK1/2 signaling is involved in leptin-mediated proliferation of renal cell carcinoma Caki-2 cellsCancer Biology & Therapy, 7
T. Spyridopoulos, E. Petridou, A. Skalkidou, N. Dessypris, G. Chrousos, C. Mantzoros, the Group (2007)
Low adiponectin levels are associated with renal cell carcinoma: A case‐control studyInternational Journal of Cancer, 120
A. Kamat, Ryan Shock, Y. Naya, C. Rosser, J. Slaton, L. Pisters (2004)
Prognostic value of body mass index in patients undergoing nephrectomy for localized renal tumors.Urology, 63 1
A. Romero‐Corral, V. Montori, V. Somers, J. Korinek, Randal Thomas, T. Allison, F. Mookadam, F. Lopez‐Jimenez (2006)
Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studiesThe Lancet, 368
J. Pinthus, N. Kleinmann, Britton Tisdale, S. Chatterjee, Jian-ping Lu, Aubrey Gillis, T. Hamlet, G. Singh, F. Farrokhyar, A. Kapoor (2008)
Lower plasma adiponectin levels are associated with larger tumor size and metastasis in clear-cell carcinoma of the kidney.European urology, 54 4
P. Poirier, J. Despres (2003)
Waist circumference, visceral obesity, and cardiovascular risk.Journal of cardiopulmonary rehabilitation, 23 3
A. Horiguchi, K. Ito, M. Sumitomo, F. Kimura, T. Asano, M. Hayakawa (2008)
Decreased serum adiponectin levels in patients with metastatic renal cell carcinoma.Japanese journal of clinical oncology, 38 2
J. Slaton, Keiji Inoue, P. Perrotte, Adel El-Naggar, D. Swanson, Isaiah Fidler, C. Dinney (2001)
Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma.The American journal of pathology, 158 2
Amaia Rodríguez, V. Catalán, J. Gómez-Ambrosi, G. Frühbeck (2007)
Visceral and subcutaneous adiposity: are both potential therapeutic targets for tackling the metabolic syndrome?Current pharmaceutical design, 13 21
D. Barb, K. Pazaitou-Panayiotou, C. Mantzoros (2006)
Adiponectin: a link between obesity and cancerExpert Opinion on Investigational Drugs, 15
S. Furukawa, T. Fujita, M. Shimabukuro, M. Iwaki, Yukio Yamada, Y. Nakajima, O. Nakayama, M. Makishima, M. Matsuda, I. Shimomura (2004)
Increased oxidative stress in obesity and its impact on metabolic syndrome.The Journal of clinical investigation, 114 12
Y. Arita, S. Kihara, N. Ouchi, Masahiko Takahashi, K. Maeda, J. Miyagawa, K. Hotta, I. Shimomura, Tadashi Nakamura, K. Miyaoka, H. Kuriyama, M. Nishida, S. Yamashita, K. Okubo, K. Matsubara, M. Muraguchi, Y. Ohmoto, T. Funahashi, Y. Matsuzawa (1999)
Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity.Biochemical and biophysical research communications, 257 1
Background: Obesity is a risk factor for renal cell carcinoma (RCC). Plasma levels of adiponectin, a hormone secreted solely by adipocytes, inversely correlate with adverse prognostic factors in RCC. Since the volume of the metabolically active visceral adipose tissue (VAT) better reflects obesity associated morbidity than body mass index (BMI), we measured and correlated it to adiponectin levels and disease characteristics in patients with clear cell RCC (ccRCC). Patients and Methods: Visceral and subcutaneous adipose tissues were measured using preoperative CT scans in 25 ccRCC patients who had no previous history of other cancers, diabetes or impaired renal function. Tissue at fat density was separated into subcutaneous and visceral components and the pixels were summed across 3 transverse slices (upper aspect of the L2 vertebral body, the umbilicus and the anterior superior iliac spine) to create a surrogate score of percentage of VAT (visceral fat area/visceral plus subcutaneous fat area). This score was correlated to preoperative fasting plasma adiponectin levels, tumor size, grade, presence of metastasis and BMI by univariate and multivariate linear regression analysis. Results: BMI correlated strongly with total but not visceral fat. Percentage of VAT correlated inversely with plasma adiponectin levels (p < 0.05) and directly with the presence of metastasis (p < 0.05) but not with grade. BMI did not predict either. Conclusion: Visceral obesity is associated with lower levels of plasma adiponectin and also appears to be associated with metastatic disease in ccRCC. CT measurements of percentage of VAT may help in preoperative prognostication of ccRCC patients.
Current Urology – Karger
Published: Jan 1, 2009
Keywords: Adiponectin; Obesity; Renal cell cancer; Visceral fat
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.