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Clinical Application of Epiderm Growth Factor in Patients with Most Severe Eye Burns

Clinical Application of Epiderm Growth Factor in Patients with Most Severe Eye Burns 20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Ophthalmologica Karger

Clinical Application of Epiderm Growth Factor in Patients with Most Severe Eye Burns

Ophthalmologica , Volume 197 (4): 6 – Jan 1, 2010

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Publisher
Karger
Copyright
© 1988 S. Karger AG, Basel
ISSN
0030-3755
eISSN
1423-0267
DOI
10.1159/000309941
Publisher site
See Article on Publisher Site

Abstract

20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium.

Journal

OphthalmologicaKarger

Published: Jan 1, 2010

Keywords: Fibronectin; Alkali burn; Regeneration; Cornea; Epithelium; Epiderm growth factor

There are no references for this article.