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/lp/karger/alterations-in-the-activity-of-certain-serum-lysosomal-hydrolases-in-KKjz0oNvFf
- Publisher
- Karger
- Copyright
- © 2008 S. Karger AG, Basel
- ISSN
- 1661-7649
- eISSN
- 1661-7657
- DOI
- 10.1159/000115411
- Publisher site
- See Article on Publisher Site
Abstract
The aim of this study was to estimate the activity of some lysosomal hydrolases in patients with an elevated prostate-specific antigen level. The activities of prostate-specific antigen, arylsuphatase, acid phosphatase, cathepsin D and α1-antitrypsin were assayed in blood serum. The highest aryl-suphatase and acid phosphatase activity and lowest cathepsin D activity were observed in men with benign prostatic hyperplasia and concomitant asymptomatic inflammation. The lowest arylsuphatase and acid phosphatase activities were revealed in prostate cancer patients, while the highest cathepsin D activity was found in patients with only benign prostatic hyperplasia. We hope that the estimation of aryl-suphatase and acid phosphatase activity may help in distinguishing between benign and malignant lesions.
Journal
Current Urology – Karger
Published: Jan 1, 2008
Keywords: Prostate-specific antigen; Prostate cancer; Benign prostatic hyperplasia; Asymptomatic prostatic inflammation; Lysosomal enzymes