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Alterations in the Activity of Certain Serum Lysosomal Hydrolases in Patients with Elevated Prostate-Specific Antigen Level Can Help in Distinguishing between Benign and Malignant Prostate Lesions

Alterations in the Activity of Certain Serum Lysosomal Hydrolases in Patients with Elevated... The aim of this study was to estimate the activity of some lysosomal hydrolases in patients with an elevated prostate-specific antigen level. The activities of prostate-specific antigen, arylsuphatase, acid phosphatase, cathepsin D and α1-antitrypsin were assayed in blood serum. The highest aryl-suphatase and acid phosphatase activity and lowest cathepsin D activity were observed in men with benign prostatic hyperplasia and concomitant asymptomatic inflammation. The lowest arylsuphatase and acid phosphatase activities were revealed in prostate cancer patients, while the highest cathepsin D activity was found in patients with only benign prostatic hyperplasia. We hope that the estimation of aryl-suphatase and acid phosphatase activity may help in distinguishing between benign and malignant lesions. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Current Urology Karger

Alterations in the Activity of Certain Serum Lysosomal Hydrolases in Patients with Elevated Prostate-Specific Antigen Level Can Help in Distinguishing between Benign and Malignant Prostate Lesions

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Publisher
Karger
Copyright
© 2008 S. Karger AG, Basel
ISSN
1661-7649
eISSN
1661-7657
DOI
10.1159/000115411
Publisher site
See Article on Publisher Site

Abstract

The aim of this study was to estimate the activity of some lysosomal hydrolases in patients with an elevated prostate-specific antigen level. The activities of prostate-specific antigen, arylsuphatase, acid phosphatase, cathepsin D and α1-antitrypsin were assayed in blood serum. The highest aryl-suphatase and acid phosphatase activity and lowest cathepsin D activity were observed in men with benign prostatic hyperplasia and concomitant asymptomatic inflammation. The lowest arylsuphatase and acid phosphatase activities were revealed in prostate cancer patients, while the highest cathepsin D activity was found in patients with only benign prostatic hyperplasia. We hope that the estimation of aryl-suphatase and acid phosphatase activity may help in distinguishing between benign and malignant lesions.

Journal

Current UrologyKarger

Published: Jan 1, 2008

Keywords: Prostate-specific antigen; Prostate cancer; Benign prostatic hyperplasia; Asymptomatic prostatic inflammation; Lysosomal enzymes

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