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Up regulation of MMP9 gene expression in female patients with multiple sclerosis

Up regulation of MMP9 gene expression in female patients with multiple sclerosis BACKGROUND: Multiple sclerosis (MS) is an inflammatory,immune-mediated, demyelinating disease of the central nervous system whichdisturbs cerebral vascular permeability.OBJECTIVE: Matrix metalloproteinase can increase capillarypermeability and are involved in neurological diseases.METHODS: The study compared the expression level of MMP9 gene inRRMS samples with normal individuals in Iran. RNA from the buffy coat of 50RRMS patients and 50 normal controls were extracted. All patients wereHLA-DRB1*15 negative and were responders to interferon-beta with a normalvitamin D level. The level of MMP9 gene expression was measured usingquantitative RT-PCR.RESULTS: The RRMS patients manifested a higher expression level ofMMP9 than their normal counterparts (P= 0.02). Age-wise, there was nocorrelation between different age groups (> 30, 30-40, 40 <). In terms of sex,only the female patients manifested a statistically significant increase inMMP9 (p value = 0.037). Besides, there was no linear correlation between MMP9expression level and risk of Expanded Disability Status Scale ofKurtzke (EDSS); nor were there any significant correlation betweenexpression status of MMP9 and duration of the disease.CONCLUSION: Up regulation of MMP9 gene expression would happen in RRMS IFN-B responders,but the level of increase in female patients is significantly more thanmales. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Antibodies IOS Press

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References (32)

Publisher
IOS Press
Copyright
Copyright © 2016 IOS Press and the authors. All rights reserved
ISSN
1093-2607
eISSN
1875-869X
DOI
10.3233/HAB-160292
pmid
28128762
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND: Multiple sclerosis (MS) is an inflammatory,immune-mediated, demyelinating disease of the central nervous system whichdisturbs cerebral vascular permeability.OBJECTIVE: Matrix metalloproteinase can increase capillarypermeability and are involved in neurological diseases.METHODS: The study compared the expression level of MMP9 gene inRRMS samples with normal individuals in Iran. RNA from the buffy coat of 50RRMS patients and 50 normal controls were extracted. All patients wereHLA-DRB1*15 negative and were responders to interferon-beta with a normalvitamin D level. The level of MMP9 gene expression was measured usingquantitative RT-PCR.RESULTS: The RRMS patients manifested a higher expression level ofMMP9 than their normal counterparts (P= 0.02). Age-wise, there was nocorrelation between different age groups (> 30, 30-40, 40 <). In terms of sex,only the female patients manifested a statistically significant increase inMMP9 (p value = 0.037). Besides, there was no linear correlation between MMP9expression level and risk of Expanded Disability Status Scale ofKurtzke (EDSS); nor were there any significant correlation betweenexpression status of MMP9 and duration of the disease.CONCLUSION: Up regulation of MMP9 gene expression would happen in RRMS IFN-B responders,but the level of increase in female patients is significantly more thanmales.

Journal

Human AntibodiesIOS Press

Published: Jan 1, 2017

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