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The Geometric Framework for Nutrition as a tool in precision medicine

The Geometric Framework for Nutrition as a tool in precision medicine Fundamental questions in nutrition include, “What constitutes a nutritionally balanced diet?”, “What are the consequences of failing to achieve diet balance?”, and “How does diet balance change across the lifecourse and with individual circumstances?”. Answering these questions requires coming to grips with the multidimensionality and dynamic nature of nutritional requirements, foods and diets, and the complex relationships between nutrition and health, while at the same time avoiding becoming overwhelmed by complexity. Here we illustrate the use of an integrating framework for taming the complexity of nutrition, the Geometric Framework for Nutrition (GFN), and show how this might be used to untap the full potential for nutrition to provide targeted primary interventions and treatments for the chronic diseases of aging. We first briefly introduce the concepts behind GFN, then provide an example of how GFN has been used to relate nutrition to various behavioural, physiological and health outcomes in a large mouse experiment, and end by suggesting a translational pathway to human health. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition and Healthy Aging IOS Press

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Publisher
IOS Press
Copyright
Copyright © 2017 © 2017 – IOS Press and the authors. All rights reserved
ISSN
2451-9480
eISSN
2451-9502
DOI
10.3233/NHA-170027
Publisher site
See Article on Publisher Site

Abstract

Fundamental questions in nutrition include, “What constitutes a nutritionally balanced diet?”, “What are the consequences of failing to achieve diet balance?”, and “How does diet balance change across the lifecourse and with individual circumstances?”. Answering these questions requires coming to grips with the multidimensionality and dynamic nature of nutritional requirements, foods and diets, and the complex relationships between nutrition and health, while at the same time avoiding becoming overwhelmed by complexity. Here we illustrate the use of an integrating framework for taming the complexity of nutrition, the Geometric Framework for Nutrition (GFN), and show how this might be used to untap the full potential for nutrition to provide targeted primary interventions and treatments for the chronic diseases of aging. We first briefly introduce the concepts behind GFN, then provide an example of how GFN has been used to relate nutrition to various behavioural, physiological and health outcomes in a large mouse experiment, and end by suggesting a translational pathway to human health.

Journal

Nutrition and Healthy AgingIOS Press

Published: Jan 1, 2017

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