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Health effects of pro- 701 tein intake in healthy adults: A systematic literature review
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(2015)
Putting the 552 balance back in diet
(2011)
549 Dietary restriction and ageing : A unifying perspective
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J. Salmerón, A. Ascherio, E. Rimm, G. Colditz, D. Spiegelman, D. Jenkins, M. Stampfer, A. Wing, W. Willett (1997)
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The 577 impact of low protein, high carbohydrate diets on aging and 578 lifespan
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K. Meyer, L. Kushi, D. Jacobs, J. Slavin, T. Sellers, A. Folsom (2000)
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K. Lee, S. Simpson, F. Clissold, R. Brooks, J. Ballard, Phil Taylor, N. Soran, D. Raubenheimer (2008)
Lifespan and reproduction in Drosophila: New insights from nutritional geometryProceedings of the National Academy of Sciences, 105
(2017)
Integrative physiology: At the cross- 546 roads of nutrition, microbiota, animal physiology and human 547 health
(2005)
Effect of 692 high protein vs high carbohydrate intake on insulin sensi- 693 tivity, body weight, hemoglobin A1c, and blood pressure 694 in patients with type 2 diabetes mellitus
M. Schulze, M. Schulz, C. Heidemann, A. Schienkiewitz, K. Hoffmann, H. Boeing (2008)
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Defining the nutritional and metabolic con- 604 text of FGF21 using the Geometric Framework. Cell Metab
Variation in type 637 2
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(2014)
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A. Sørensen, D. Mayntz, D. Raubenheimer, S. Simpson (2008)
Protein‐leverage in Mice: The Geometry of Macronutrient Balancing and Consequences for Fat DepositionObesity, 16
D. Raubenheimer, S. Simpson, D. Couteur, Samantha Solon-Biet, Sean Coogan (2016)
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Complex Trait Consor- 666 tium. The Collaborative Cross, a community resource for the 667 genetic analysis of complex traits
(2012)
Dietary balance during pregnancy predicts fetal adiposity and 619 fat distribution
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Testing Protein Leverage in Lean Humans: A Randomised Controlled Experimental StudyPLoS ONE, 6
(1958)
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S. Simpson, D. Raubenheimer (2015)
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Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin ResistanceNutrients, 7
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Integrating nutrients, foods, diets, and appetites with obesity and cardiometabolic healthObesity, 23
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Annual Data Report: 720 Liver
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D. Raubenheimer, G. Machovsky-Capuska, A. Gosby, S. Simpson (2014)
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W. Oddy, C. Herbison, P. Jacoby, G. Ambrosini, T. O’Sullivan, O. Ayonrinde, J. Olynyk, L. Black, L. Beilin, Trevor Mori, B. Hands, L. Adams (2013)
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D. Couteur, Samantha Solon-Biet, Devin Wahl, V. Cogger, Bradley Willcox, D. Willcox, D. Raubenheimer, Stephen Simpson (2016)
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D. Couteur, S. Wilder, R. Cabo, S. Simpson (2014)
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Samantha Solon-Biet, V. Cogger, T. Pulpitel, M. Heblinski, Devin Wahl, A. Mcmahon, A. Warren, Jessica Durrant-Whyte, K. Walters, J. Krycer, F. Ponton, R. Gokarn, J. Wali, K. Ruohonen, A. Conigrave, D. James, D. Raubenheimer, C. Morrison, D. Couteur, S. Simpson (2016)
Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework.Cell metabolism, 24 4
S. Simpson, D. Couteur, D. Raubenheimer (2015)
Putting the Balance Back in DietCell, 161
OPTN / SRTR 2013 Annual Data Report : 720 Liver
K. Hall, Juen Guo (2017)
Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition.Gastroenterology, 152 7
L. Masson, G. Mcneill, A. Avenell (2003)
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743 Protein leverage and energy intake
(2008)
572 Protein leverage in mice : Geometry of macronutrient 573 balancing and consequences for fat deposition
A. Wong, A. Holmes, F. Ponton, M. Lihoreau, K. Wilson, D. Raubenheimer, S. Simpson (2015)
Behavioral Microbiomics: A Multi-Dimensional Approach to Microbial Influence on BehaviorFrontiers in Microbiology, 6
(2015)
Behavioural microbiomics: A multi-dimensional approach to microbial influence on behaviour
Z. Younossi, Aaron Koenig, Dinan Abdelatif, Yousef Fazel, L. Henry, M. Wymer (2016)
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomesHepatology, 64
(2012)
The Nature of Nutrition: A 526 Unifying Framework fr m Animal Adaptation to Human 527 Obesity
Fundamental questions in nutrition include, “What constitutes a nutritionally balanced diet?”, “What are the consequences of failing to achieve diet balance?”, and “How does diet balance change across the lifecourse and with individual circumstances?”. Answering these questions requires coming to grips with the multidimensionality and dynamic nature of nutritional requirements, foods and diets, and the complex relationships between nutrition and health, while at the same time avoiding becoming overwhelmed by complexity. Here we illustrate the use of an integrating framework for taming the complexity of nutrition, the Geometric Framework for Nutrition (GFN), and show how this might be used to untap the full potential for nutrition to provide targeted primary interventions and treatments for the chronic diseases of aging. We first briefly introduce the concepts behind GFN, then provide an example of how GFN has been used to relate nutrition to various behavioural, physiological and health outcomes in a large mouse experiment, and end by suggesting a translational pathway to human health.
Nutrition and Healthy Aging – IOS Press
Published: Jan 1, 2017
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