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The emerging concept of pathogenic natural autoantibodies

The emerging concept of pathogenic natural autoantibodies Natural autoantibodies (NAA) are self-reacting antibodies found in the serum. NAA do not require antigenic or mitogenic stimuli for their synthesis. These low affinity antibodies are found in the sera of normal healthy subjects and animals and are thought to constitute part of the innate immunity by providing a first line of defense against foreign invading pathogens. In this paper we summarize the recently accumulated data which points to the pathogenic potential of NAA, challenging the paradigm of nonharmful antibodies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Antibodies IOS Press

The emerging concept of pathogenic natural autoantibodies

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References (36)

Publisher
IOS Press
Copyright
Copyright © 1997 by IOS Press, Inc
ISSN
1093-2607
eISSN
1875-869X
DOI
10.3233/HAB-1997-8204
Publisher site
See Article on Publisher Site

Abstract

Natural autoantibodies (NAA) are self-reacting antibodies found in the serum. NAA do not require antigenic or mitogenic stimuli for their synthesis. These low affinity antibodies are found in the sera of normal healthy subjects and animals and are thought to constitute part of the innate immunity by providing a first line of defense against foreign invading pathogens. In this paper we summarize the recently accumulated data which points to the pathogenic potential of NAA, challenging the paradigm of nonharmful antibodies.

Journal

Human AntibodiesIOS Press

Published: Jan 1, 1997

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