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The effectiveness of vitamin D supplementation in reducing depressive symptoms: A systematic review and meta-analysis of Randomized Controlled Trials (RCTs)

The effectiveness of vitamin D supplementation in reducing depressive symptoms: A systematic... BACKGROUND:Depression is a widespread, global problem, increasingly linked with vitamin D deficiency in the literature. However, a knowledge gap persists regarding the relationship between depressive symptoms and vitamin D intake.OBJECTIVE:To determine the association between vitamin D supplementation and depressive symptoms in adults (aged 18+ years).METHODS:This study consists of a systematic review and meta-analysis of randomized controlled trials (RCTs), published before January 2019. Pooled summary estimates and between-study heterogeneity were examined.RESULTS:Ten RCTs (total participants = 3336; median duration = 12 months) were included. An association was found between high vitamin D supplementation (≥4000 IU) and reduced depressive symptoms, but not in the case of lower levels of vitamin D supplementation (<4000 IU). Neither baseline serum vitamin D before supplementation, nor the depression-scoring scales used affected this association. The overall quality of evidence was graded as ‘moderate’.CONCLUSIONS:Vitamin D supplementation at greater than 4000 IU was observed to have a positive effect on depressive symptoms. Future efforts could focus on obtaining higher-quality evidence with standardized RCT methodologies to confirm this association. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nutrition and Healthy Aging IOS Press

The effectiveness of vitamin D supplementation in reducing depressive symptoms: A systematic review and meta-analysis of Randomized Controlled Trials (RCTs)

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Publisher
IOS Press
Copyright
Copyright © 2021 © 2021 – The authors. Published by IOS Press
ISSN
2451-9480
eISSN
2451-9502
DOI
10.3233/nha-200094
Publisher site
See Article on Publisher Site

Abstract

BACKGROUND:Depression is a widespread, global problem, increasingly linked with vitamin D deficiency in the literature. However, a knowledge gap persists regarding the relationship between depressive symptoms and vitamin D intake.OBJECTIVE:To determine the association between vitamin D supplementation and depressive symptoms in adults (aged 18+ years).METHODS:This study consists of a systematic review and meta-analysis of randomized controlled trials (RCTs), published before January 2019. Pooled summary estimates and between-study heterogeneity were examined.RESULTS:Ten RCTs (total participants = 3336; median duration = 12 months) were included. An association was found between high vitamin D supplementation (≥4000 IU) and reduced depressive symptoms, but not in the case of lower levels of vitamin D supplementation (<4000 IU). Neither baseline serum vitamin D before supplementation, nor the depression-scoring scales used affected this association. The overall quality of evidence was graded as ‘moderate’.CONCLUSIONS:Vitamin D supplementation at greater than 4000 IU was observed to have a positive effect on depressive symptoms. Future efforts could focus on obtaining higher-quality evidence with standardized RCT methodologies to confirm this association.

Journal

Nutrition and Healthy AgingIOS Press

Published: Apr 13, 2022

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