Access the full text.
Sign up today, get DeepDyve free for 14 days.
References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.
BACKGROUND: Although Multiple Sclerosis (MS) is an autoimmunemultifactorial disease with unknown etiology, various genetic andenvironmental factors are known to contribute to the pathogenesis of thedisease. OBJECTIVE: Recent studies have confirmed thatthe suppressive function of regulatory T cells (T (reg)) is impaired in MSpatients and that the FOXP3 gene is a crucial transcription factor in theregulation of CD4+CD25+FOXP3+ Treg cells. Polymorphisms inthe promoter region of the FOXP3 gene may alter the gene expression level and,therefore, contribute to the disease susceptibility. METHODS: Thepresent study aimed to investigate the possible association between singlenucleotide polymorphisms (SNPs) rs3761548 and rs2232365 in the FOXP3 gene andpredisposition to MS. We conducted a case-control study on 410 patients withsporadic MS and 446 healthy controls. Genotyping was performed usingpolymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP). RESULTS: Significant differences in distribution ofboth rs3761548 and rs2232365 A allele were found in MS patients incomparison to controls. Haplotype frequencies were also different among thestudied groups. The A-A and C-G haplotype blocks showed a significantdifference between case and controls. CONCLUSION: we have providedfurther evidence for the association between genetic variations andhaplotypes in FOXP3 and MS in Iranian population.
Human Antibodies – IOS Press
Published: Jan 1, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.