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not provided. IFN activation and to explore their potential application as novel therapeutics for the treatment of disease. Toward this objective we have employed combinatorial libraries of synthetic antibody fragments expressed on the surface of phage particles to select speciï¬cally for antibodies with these attributes and will discuss our efforts in isolating and characterizing these novel tools. [09.30â09.50] âTargeting the interferon network with synthetic antibodiesâ Shane Miersch, Ashlesha Deshpande, Srilalitha kuruganti, Kumar Putcha, Mark Walter and Sachdev Sidhu University of Toronto, Toronto, Ontario, Canada Since the discovery of interferons (IFNs) in the late 1950âs, investigation has revealed that these cytokines possesspleiotropicanti â viral, anti â tumourandimmunomodulatory activity. In light of this they have found therapeutic application in the treatment of a variety of viral, oncologic and autoimmune disorders. Alternately, dysregulation of IFNs is thought to contribute to disease in other milieus, potentially contributing to a loss of immune tolerance and the development of autoimmunity. Nevertheless, structural variations in ligand â receptor interactions that are responsible for the divergent activities that the 13+ Type I IFNs exert in binding to a single heterodimeric receptor have yet to be elucidated. Considering the uncharacterized facets of IFN biology and its potential
Human Antibodies – IOS Press
Published: Jan 1, 2011
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