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Session 8: Infectious diseases

Session 8: Infectious diseases Human Antibodies 11 (2002) 25–28 IOS Press Wednesday 18 September 2002, Moderator: Alois Lang [09.30–10.00] Molecular dissection of the anti-HCV humoral response by phage display repertoire cloning Roberto Burioni a , Nicasio Mancinia , Filippo Canduccib, Antonella Grieco a , Pietro E. Varaldo a and Massimo Clementib a ` Istituto di Microbiologia, Universit a di Ancona, Ancona, Italy b Universit` Vita-Salute San Raffaele, IRCCS Istituto a Scientifico San Raffaele, Milano, Italy Clinical and experimental evidence indicates hepatitis C virus E2 glycoprotein (HCV/E2) as the most promising candidate for the development of an effective anti-HCV vaccine. Reinfection can however occur even in the presence of vigorous production of antiHCV/E2 antibodies. Dissection of the human immune response against HCV/E2 showed highly variable neutralization of binding of HCV/E2 to target cells (NOB activity) among antibody clones, which probably accounts for the lack of correlation between anti-HCV/E2 titer and NOB acrivity in human sera. Identifying the human epitopes conserved among isolates and able to elicit protective antibodies would thus constitute a significant step forward. Here we describe the mapping of the B-cell epitopes present on the surface of HCV/E2, as recognized by the immune system during infection, by the analysis of the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Antibodies IOS Press

Session 8: Infectious diseases

Human Antibodies , Volume 11 (1) – Jan 1, 2002
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Publisher
IOS Press
Copyright
Copyright © 2002 by IOS Press, Inc
ISSN
1093-2607
eISSN
1875-869X
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Abstract

Human Antibodies 11 (2002) 25–28 IOS Press Wednesday 18 September 2002, Moderator: Alois Lang [09.30–10.00] Molecular dissection of the anti-HCV humoral response by phage display repertoire cloning Roberto Burioni a , Nicasio Mancinia , Filippo Canduccib, Antonella Grieco a , Pietro E. Varaldo a and Massimo Clementib a ` Istituto di Microbiologia, Universit a di Ancona, Ancona, Italy b Universit` Vita-Salute San Raffaele, IRCCS Istituto a Scientifico San Raffaele, Milano, Italy Clinical and experimental evidence indicates hepatitis C virus E2 glycoprotein (HCV/E2) as the most promising candidate for the development of an effective anti-HCV vaccine. Reinfection can however occur even in the presence of vigorous production of antiHCV/E2 antibodies. Dissection of the human immune response against HCV/E2 showed highly variable neutralization of binding of HCV/E2 to target cells (NOB activity) among antibody clones, which probably accounts for the lack of correlation between anti-HCV/E2 titer and NOB acrivity in human sera. Identifying the human epitopes conserved among isolates and able to elicit protective antibodies would thus constitute a significant step forward. Here we describe the mapping of the B-cell epitopes present on the surface of HCV/E2, as recognized by the immune system during infection, by the analysis of the

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Human Antibodies – IOS Press

Published: Jan 1, 2002

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