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Session 6: Infectious Diseases I

Session 6: Infectious Diseases I not provided. [11.30–12.00] ‘Human monoclonal antibodies against influenza A viruses’ Roberto Burioni Universit` Vita-Salute San Raffaele, Milano, Italy a The role played by humoral response in controlling infection by influenza viruses has been repeatedly demonstrated in several clinical and experimental settings. However, the potential prophylactic or therapeutic role of monoclonal antibodies in this field have been argumented because of the high viral variability, and ISSN 1093-2607/10/$27.50 © 2010 – IOS Press and the authors. All rights reserved therefore because of the lack of molecules endowed with broadly neutralizing activity. In this presentation, we describe two human monoclonal antibodies (HMabs), named PN-SIA49 and PNSIA-28 endowed with outstanding homosubtypic and heterosubtypic neutralizing activity, respectively. Both antibodies were obtained from of a 55-year-old patient, vaccinated with the seasonal vaccine and with a negative clinical history of infection with influenza virus in the past 10 years. Both monoclonals were shown to be directed against hemagglutinin (HA), and to neutralize in different in vitro assays all tested H1N1 strains (A/Puerto Rico/8/34; A/Wilson-Smith/33; A/Malaya/302/54; A/ New Caledonia/20/99), including an isolate of the recent H1N1v/2009 strain (A/Milan/UHSR1/2009). For both HMabs IC50 against all tested isolates were in the subnanomolar range. Notably, cells transfected with the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Antibodies IOS Press

Session 6: Infectious Diseases I

Human Antibodies , Volume 19 (2) – Jan 1, 2010
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Publisher
IOS Press
Copyright
Copyright © 2010 by IOS Press, Inc
ISSN
1093-2607
eISSN
1875-869X
DOI
10.3233/HAB-2010-0222
Publisher site
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Abstract

not provided. [11.30–12.00] ‘Human monoclonal antibodies against influenza A viruses’ Roberto Burioni Universit` Vita-Salute San Raffaele, Milano, Italy a The role played by humoral response in controlling infection by influenza viruses has been repeatedly demonstrated in several clinical and experimental settings. However, the potential prophylactic or therapeutic role of monoclonal antibodies in this field have been argumented because of the high viral variability, and ISSN 1093-2607/10/$27.50 © 2010 – IOS Press and the authors. All rights reserved therefore because of the lack of molecules endowed with broadly neutralizing activity. In this presentation, we describe two human monoclonal antibodies (HMabs), named PN-SIA49 and PNSIA-28 endowed with outstanding homosubtypic and heterosubtypic neutralizing activity, respectively. Both antibodies were obtained from of a 55-year-old patient, vaccinated with the seasonal vaccine and with a negative clinical history of infection with influenza virus in the past 10 years. Both monoclonals were shown to be directed against hemagglutinin (HA), and to neutralize in different in vitro assays all tested H1N1 strains (A/Puerto Rico/8/34; A/Wilson-Smith/33; A/Malaya/302/54; A/ New Caledonia/20/99), including an isolate of the recent H1N1v/2009 strain (A/Milan/UHSR1/2009). For both HMabs IC50 against all tested isolates were in the subnanomolar range. Notably, cells transfected with the

Journal

Human Antibodies – IOS Press

Published: Jan 1, 2010

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