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Human Antibodies 19 (2010) 35â37 DOI 10.3233/HAB-2010-0219 IOS Press Wednesday 14th April 2010. Moderator: Zdenka L. Jonak [14.00â14.30] âDevelopment of therapeutic antibodies: Challenges and opportunitiesâ Yan Wu NovartisBiologics, Shanghai, China To date, the most difï¬cult challenge to antibodybased therapy for a variety of diseases, particularly for cancer, is the balance of robust efï¬cacy and minimal side effects on normal tissues. In the case of cancer intervention, it is highly desirable to have a therapeutics controlling metastasis that accounts for most death of cancer patients and enhancing antitumor immunity that is seriously weakened in patients with cancer. Antibody-directed therapeutics has been primarily focused on targeting a speciï¬c molecule that is functional in the pathogenesis of diseases. Antibody combination and bispeciï¬c antibody targeting disorder-associated cells or factors have been explored in the past years. Alternatively, the development of a therapeutic antibody targeting multiple molecules that involve in the pathogenesis and progression of one or more disease types will be also preferable. [14.30â14.50] âClinical experience in a phase IIa trail with the human monoclonal IgM antibody Panobacumab in ventilator associated pneumonia caused by P.aeruginosaâ Michael Rudolf Kenta Biotech AG, Bern, Switzerland Kenta Biotech, founded in 2006 in Switzerland, is focusing on
Human Antibodies – IOS Press
Published: Jan 1, 2010
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