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Potential of primate monoclonal antibodies to substitute for human antibodies: nucleotide sequence of chimpanzee Fab fragments

Potential of primate monoclonal antibodies to substitute for human antibodies: nucleotide... The nucleotide sequence of the mRNA that codes for Fabfragmentsfrom two chimpanzee monoclonal antibodies has been determined. Both antibodies have high affinity and good specificity for digoxin. Four domains from the two antibodies have been sequenced: the constant domains of the kappa and lambda light chains, the variable domain of the lambda light chain, and the C Hl domain of the IgG 1 heavy chain. There are very few differences between the chimpanzee and human sequences; the nucleotide sequences differ by less than 2%. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Human Antibodies IOS Press

Potential of primate monoclonal antibodies to substitute for human antibodies: nucleotide sequence of chimpanzee Fab fragments

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References (10)

Publisher
IOS Press
Copyright
Copyright © 1990 by IOS Press, Inc
ISSN
1093-2607
eISSN
1875-869X
DOI
10.3233/HAB-1990-1105
Publisher site
See Article on Publisher Site

Abstract

The nucleotide sequence of the mRNA that codes for Fabfragmentsfrom two chimpanzee monoclonal antibodies has been determined. Both antibodies have high affinity and good specificity for digoxin. Four domains from the two antibodies have been sequenced: the constant domains of the kappa and lambda light chains, the variable domain of the lambda light chain, and the C Hl domain of the IgG 1 heavy chain. There are very few differences between the chimpanzee and human sequences; the nucleotide sequences differ by less than 2%.

Journal

Human AntibodiesIOS Press

Published: Jan 1, 1990

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