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Janet Williams (2013)
Diagnostic and Statistical Manual of Mental Disorders
- Publisher
- IOS Press
- Copyright
- Copyright © 2021 © 2021 – The authors. Published by IOS Press
- eISSN
- 2542-4823
- DOI
- 10.3233/ADR-210008
- Publisher site
- See Article on Publisher Site
Abstract
Background:Amyloid-β (Aβ), the key constituent of Alzheimer’s disease (AD) plaques, has antimicrobial properties.Objective:To investigate the association between plasma Aβ and antibodies against the AD-related pathogens herpes simplex virus (HSV), cytomegalovirus (CMV), and C. pneumoniae.Methods:Plasma from 339 AD cases, obtained on average 9.4 years (±4.00) before diagnosis, and their matched controls were analyzed for Aβ40 and Aβ42 concentrations with Luminex xMAP technology and INNOBIA plasma Aβ-form assays. Enzyme-linked immunosorbent assays were utilized for analyses of anti-HSV immunoglobulin (Ig) G, anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG. Follow-up samples were available for 150 of the cases.Results:Presence and levels of anti-HSV1 IgG, anti-HSV2 IgG, anti-CMV IgG, and anti-C. pneumoniae IgG did not correlate with concentrations of Aβ42 or Aβ40 in cases or controls.Conclusion:Levels of plasma Aβ were not associated with antibodies against different AD-related pathogens.
Journal
Journal of Alzheimer's Disease Reports – IOS Press
Published: Apr 6, 2021